Preparation method of parthenolide

A parthenolide and ethyl acetate technology, applied in the direction of organic chemistry and the like, can solve the problems of complicated process, high production cost, and low parthenolide content, and achieve the effect of simple extraction and separation process and easy industrialization.
CN102241684AActive Publication Date: 2011-11-16新沂尚德药缘药业有限公司 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
新沂尚德药缘药业有限公司
Publication Date
2011-11-16

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Abstract

The invention relates to an extraction and preparation method of parthenolide, and particulary relates to an extraction method of parthenolide from Magnolia grandiflora root bark. The extraction and preparation method comprises: crushing Magnolia grandiflora root bark as a raw material, extracting with an appropriate polar organic solvent to obtain total lactones, separating the total lactones by column chromatography, collecting the required ingredients, and then crystallizing the collected ingredients with an appropriate solvent to obtain parthenolide. The extraction method of parthenolide from Magnolia grandiflora root bark provided by the invention is suitable for industrial production.
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Description

technical field

[0001] The invention belongs to the technical field of medicine extraction. Specifically, the invention relates to a preparation method of parthenolide, in particular to a method for extracting parthenolide from root bark of Magnolia magnoliae. Background technique

[0002] Tumors are a great threat to human health. There are about 2 million cancer patients in my country, with 1.6 million new cases every year. This is a large group. Anti-tumor research is a very challenging and significant field in the field of life sciences today. . In the past, the treatment methods focused on the eradication and killing of cancer cells. At present, the commonly used antineoplastic drugs in clinical practice are mainly cytotoxic drugs. These anticancer drugs have disadvantages such as poor selectivity, strong toxic and side effects, and easy drug resistance. , is a typical double-edged drug, and it is difficult to eradicate cancer, and many cancers have a high recurrence ra...

Claims

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