Preparation method of parthenolide

A parthenolide and ethyl acetate technology, applied in the direction of organic chemistry and the like, can solve the problems of complicated process, high production cost, and low parthenolide content, and achieve the effect of simple extraction and separation process and easy industrialization.

Active Publication Date: 2011-11-16
新沂尚德药缘药业有限公司 +1
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  • Application Information

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Problems solved by technology

[0007] Patent CN101190258 discloses a method of extracting rich parthenolide extract from leaves or flowers of Magnolia Magnolia, but the content of parthenolide in leaves or flowers of Magnolia Magnolia used in the method is not too high (content is about 0.3 %), and the process is more cumbersome and the production cost is higher

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  • Preparation method of parthenolide

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Embodiment 1

[0025] Embodiment 1: Preparation of parthenolide

[0026] Take 1 kg of dry root bark of Magnolia Magnolia, and grind it into powder. Get the pulverized coarse powder, soak 3 times with 10 times (weight) of 95% ethanol at room temperature, each time for 72 hours. Filtrate, combine the filtrates, and recover the solvent under reduced pressure to obtain the extract. The extract was dissolved with 20% ethanol, then extracted with ethyl acetate until the color of the extract became lighter, the organic solvent was combined, the solvent was recovered under reduced pressure, and dried to obtain 104 grams of solid. Put on a silica gel chromatography column, elute with petroleum ether: ethyl acetate = 15:1 ~ 4:1 gradient, TLC tracking detection, compare with standard parthenolide, collect fractions containing parthenolide, combine and reduce pressure The solvent was recovered to obtain a dry solid. Crystallize in a mixed solvent of petroleum ether: acetone = 10:1 to obtain 50 g of c...

Embodiment 2

[0030] Embodiment 2: with the comparative embodiment of Guang Yulan dry leaf

[0031] In order to better illustrate the present invention, according to the method for extracting a parthenolide-rich extract disclosed in CN101190258, 2.5 g of parthenolide was isolated and purified from 1 kg of Magnolia glabra dry leaves, and the yield was only 0.25%. And the process is more loaded down with trivial details, and the production cost is higher.

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Abstract

The invention relates to an extraction and preparation method of parthenolide, and particulary relates to an extraction method of parthenolide from Magnolia grandiflora root bark. The extraction and preparation method comprises: crushing Magnolia grandiflora root bark as a raw material, extracting with an appropriate polar organic solvent to obtain total lactones, separating the total lactones by column chromatography, collecting the required ingredients, and then crystallizing the collected ingredients with an appropriate solvent to obtain parthenolide. The extraction method of parthenolide from Magnolia grandiflora root bark provided by the invention is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine extraction. Specifically, the invention relates to a preparation method of parthenolide, in particular to a method for extracting parthenolide from root bark of Magnolia magnoliae. Background technique [0002] Tumors are a great threat to human health. There are about 2 million cancer patients in my country, with 1.6 million new cases every year. This is a large group. Anti-tumor research is a very challenging and significant field in the field of life sciences today. . In the past, the treatment methods focused on the eradication and killing of cancer cells. At present, the commonly used antineoplastic drugs in clinical practice are mainly cytotoxic drugs. These anticancer drugs have disadvantages such as poor selectivity, strong toxic and side effects, and easy drug resistance. , is a typical double-edged drug, and it is difficult to eradicate cancer, and many cancers have a high recurrence ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04
Inventor 张泉龙寿江陈悦翟佳黛张福武范洪霞马维维
Owner 新沂尚德药缘药业有限公司
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