2results about How to "Solve yield" patented technology

The invention relates to the field of metal nano material preparation, and discloses a supersonic gas atomization preparation method of high-dispersity spherical nano aluminum powder, which comprises the following steps: establishing a constant-temperature aluminum melt flow, and constructing a supersonic gas-solid two-phase atomization jet flow; nitrogen with the temperature lower than the melting point of the particles is used for carrying flow, solid zinc stearate particles are carried and accelerated to supersonic speed, and the aluminum melt flow is impacted; solid rigid momentum of the particles penetrates through an aluminum liquid interface to enter liquid drops, thermal relaxation time difference is used for inducing the particles to generate phase change decomposition in the liquid drops, the liquid drops are broken from the inside through volume expansion, and a carbon-zinc composite isolation layer is formed in situ through decomposition products. And high-efficiency nanocrystallization crushing under low energy consumption is realized.

This invention relates to a method for synthesizing 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinoline-3-carboxylic acid, a key intermediate for numonoxacin. The method uses 2,4-difluoro-3-methoxyacetophenone as a starting material and proceeds through four steps: haloform reaction, acyl chloride formation and Maxwell's acid condensation, reaction with dimethylformamide dimethyl acetal and cyclopropylamine, and base-catalyzed cyclization and acid deprotection. This efficient method yields the target intermediate. The synthetic route of this invention utilizes readily available raw materials, mild reaction conditions, and simple operation. The multi-step reaction can be carried out in a one-pot process, achieving a total conversion rate of approximately 85% and a product purity exceeding 99.5%, making it suitable for industrial production.