Method for synthesizing piperidine and homolog thereof from N-pyridine oxide and homolog thereof

Abstract

The invention discloses a method for synthesizing piperidine and homolog thereof from N-pyridine oxide and homolog thereof. The method comprises the following steps: firstly weighing 95-110g of N-pyridine oxide and homolog thereof, 63g of formic acid and 500mL of a solvent, putting the N-pyridine oxide and homolog thereof and ammonium formate into a reaction kettle, adding the solvent, controllingthe temperature to 25-35 DEG C, uniformly stirring to carry out a reaction, washing with water after stirring is completed, and finally carrying out vacuum distillation to remove the solvent, therebyobtaining a product. By adopting the method disclosed by the invention, the problems that piperidine and homolog thereof are serious in environment pollution, low in yield, high in temperature and pressure, high in energy consumption and the like in a synthesis process since acid radical anion is generated can be solved, the method has the advantages of good environment protection, energy conservation, security and high yields, the yield of the product is up to 95% or greater, which is far greater than that of a conventional cycloaddition method, in addition, when reactions are carried out under normal temperature and normal pressure conditions, energy consumption in the reaction process can be reduced, the purposes of energy conservation and environment protection are achieved, and wideapplication prospects can be met.

Description

technical field [0001] The invention relates to the technical field of organic compound synthesis, in particular to a method for synthesizing piperidine and its homologues with N-oxidized pyridine and its homologues. Background technique [0002] The synthetic methods of piperidine and its homologs are generally divided into cyclization method, cycloaddition method and hydrogenation reduction method. According to the different properties of the bond, the cyclization method can be divided into two categories: (1) by forming a C-N bond to form The cyclization method of the ring; (2) the cyclization method of forming a ring by forming a C-C bond. However, this method will produce a large amount of acid radical anions, which will pollute the environment relatively; the cycloaddition method can synthesize a six-membered heterocycle with biological activity, but this method has obvious limitations in actual production and application because the yield is too low; The hydrogenatio...

AI Technical Summary

Problems solved by technology

However, this method will produce a large amount of acid radical anions, which will pollute the environment relatively; the cycloaddition method can synthesize a six-membered heterocycle with biological activity, but this method has obvious limitations in actual production and application because the yield is too low; The hydrogenation reduction method is to react pyridine under high temperature and high pressure conditions in a hydrogen atmosphere to obtain piperidine. This method has a high yield, but because the reducing agent is hydrogen, the risk of the reaction is increased, and the reaction is performed under high temperature and high pressure conditions, which consumes energy also too big

In order to solve the problem of large environmental pollution, low yield, high energy consumption such as high temperature and high pressure due to the production of acid radical anions in the synthesis process of piperidine and its homologues, and it is more dangerous