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Method for implementing transfer of up-conversion nanocrystals from oil phase to aqueous phase

A nanocrystalline and oil-phase technology, applied in chemical instruments and methods, luminescent materials, etc., can solve the problems of different reaction conditions, lack of universality, complex methods, etc., achieve good experimental repeatability, and maintain the effect of luminescent performance

Inactive Publication Date: 2011-11-16
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The previous method is to use macromolecular polymers to modify, and it is necessary to control pH, temperature, time, etc. under the condition of nitrogen protection. The method is complicated, and the reaction conditions of each method are different, which lacks universality.

Method used

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  • Method for implementing transfer of up-conversion nanocrystals from oil phase to aqueous phase
  • Method for implementing transfer of up-conversion nanocrystals from oil phase to aqueous phase
  • Method for implementing transfer of up-conversion nanocrystals from oil phase to aqueous phase

Examples

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Effect test

Embodiment 1

[0025] Add 0.04g of anionic surfactant SDS to 10ml of water, dissolve after stirring to obtain a colorless and transparent solution, then add 2ml with a concentration of 1.9×10 -2 mol / L NaYF 4 (moles 18% Yb, 2% Er,) in chloroform solution; heated to 70 degrees Celsius to volatilize chloroform, cooled to room temperature, and obtained colorless and transparent aqueous phase NaYF 4 (Mole number 18% Yb, 2% Er) solution. As shown in Figure 1(a), the luminescence spectrum of the up-converting nanocrystal is given, which proves that the nanocrystal has the property of up-converting; Figure 1(b) shows the transmission electron microscope photo of the nanocrystal in the chloroform phase, It can be seen from the figure that the size of the nanocrystals is uniform and the dispersion is very good; Figure 1(c) shows the TEM photo of the nanocrystals in the water phase, we can see that the particles are not aggregated and the dispersion is very good, which proves that the oil phase The n...

Embodiment 2

[0027] Add 0.04g cationic surfactant CTAB to 10ml water, dissolve after stirring to obtain a colorless transparent solution, add 2ml concentration to 1.9×10 -2 mol / L NaYF 4 (moles 18% Yb, 2% Er) chloroform solution; heated to 70 degrees Celsius to volatilize chloroform, cooled to room temperature to obtain colorless and transparent aqueous phase NaYF 4 (Mole number 18% Yb, 2% Er) solution. As shown in Figure 1(b), the transmission electron micrograph of the nanocrystals in the chloroform phase is given, figure 2 The transmission electron microscope photos of the nanocrystals in the water phase are given, we can see that the particles are not aggregated, and the dispersion is very good, which proves that the nanocrystals in the oil phase have been successfully transferred to the water phase.

Embodiment 3

[0029] Add 0.04g cationic surfactant DTAB to 10ml water, dissolve after stirring to obtain a colorless transparent solution, add 2ml concentration to 1.9×10 -2 mol / L NaYF 4 (mole number 18%Yb, 2%Er) chloroform solution; heating to 70 degrees Celsius makes chloroform volatilize, cools to room temperature, obtains colorless and transparent water phase NaYF4 (mole number 18%Yb, 2%Er) solution . As shown in Figure 1(b), the transmission electron micrograph of the nanocrystals in the chloroform phase is given, image 3 The transmission electron microscope photos of the nanocrystals in the water phase are given, we can see that the particles are not aggregated, and the dispersion is very good, which proves that the nanocrystals in the oil phase have been successfully transferred to the water phase.

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Abstract

The invention belongs to the technical field of functional inorganic nanocrystal surface modification, and relates to a method for transferring oil-soluble up-conversion nanocrystals to an aqueous phase so as to improve the biocompatibility of the up-conversion nanocrystals. The method comprises the following steps of: dissolving 0.02 to 0.2g of small molecular surfactant in 10 to 20ml of water in a room temperature open system; and adding 1 to 4 ml of up-conversion nanocrystal solution prepared by dissolving up-conversion nanocrystals in a low boiling point organic solvent, and heating to the temperature of between 55 and 80DEG C to volatilize the organic solvent so as to obtain the water-soluble up-conversion nanocrystals. By lyophobic-lyophobic interaction of the small molecular surfactant and ligands on the surfaces of the up-conversion nanocrystals, stable coating layers are formed, and the hydrophobicity of the surfaces of the nanocrystals is changed to hydrophilcity. The method is easy and convenient to implement; different surfactants can be introduced according to requirements; a problem that the up-conversion nanocrystals are hardly transferred from the oil phase to the aqueous phase is solved; and the method provides a reaction platform for coupling the up-conversion nanocrystals with biomolecules and other materials.

Description

technical field [0001] The invention belongs to the technical field of surface modification of functional inorganic nanocrystals, and in particular relates to a universal method for transferring oil-soluble up-conversion nanocrystals to a water phase, thereby increasing the biocompatibility of the up-conversion nanocrystals. Background technique [0002] Up-converting nanocrystals have unique optical properties, can absorb two or more low-energy photons, and excite one high-energy photon, so they have become a hot spot in the research of new materials and are used in many basic research fields, such as solid-state lasers, Light emitting devices, biological probes, biological testing, low-density infrared imaging, etc. However, the surface of the up-converting nanocrystals prepared by the existing technology is covered with hydrophobic alkyl chains, and can only be dispersed in non-polar solvents such as toluene and chloroform, so as to realize the further application of such...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02
Inventor 张皓梁森刘轶杨柏
Owner JILIN UNIV
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