Dynamic Surface Enhanced Raman Spectroscopy Detection Method

A surface-enhanced Raman and spectral detection technology, which is applied in the field of analysis and detection, can solve the problems of staying, cumbersome operation, and complicated operating conditions, and achieve the effect of high cost investment, high energy consumption, and high sensitivity

Inactive Publication Date: 2011-11-30
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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  • Claims
  • Application Information

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Problems solved by technology

For more than three decades, despite detection limits as high as 10 -12 -10 -14 M's SERS substrates have been reported, but their preparation techniques and operating conditions are extremely complicated, and the operation is cumbersome, and they can only stay in the laboratory stage, so it is difficult to promote their use.
Too complicated SERS substrate preparation and programming scheme has no practical and commercial value in terms of detection cost
In addition, the research energy consumption of these ultr

Method used

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  • Dynamic Surface Enhanced Raman Spectroscopy Detection Method
  • Dynamic Surface Enhanced Raman Spectroscopy Detection Method
  • Dynamic Surface Enhanced Raman Spectroscopy Detection Method

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[0069]

[0070] Experimental result one:

[0071] The present invention adopts the SERS substrate preparation scheme reported in the document "Facile size-controlled synthesis of silver nanoparticles in UV-irradiated tungstosilicate acid solution", based on the traditional SERS test scheme, for rhodamine (R6G), 4-mercaptopyridine (4-mercaptopyridine) -ATP), p-aminothiophenol (4-ATP), the detection limit cannot exceed 10 -6 M, and its test results are shown in image 3 .

[0072]

[0073] Experiment 2.

[0074] One of the detection methods of dynamic surface-enhanced Raman spectroscopy is to drop ethanol onto the SERS sink containing the target molecule to be detected, and then detect the target signal under the Raman spectrometer. Using this method to detect R6G, the test results are obviously better than image 3 The traditional SERS test scheme in the Figure 4 .

[0075] by comparison Figure 4 and image 3 , it can be clearly found that this method can improve th...

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Abstract

The invention belongs to an analysis and detection technology, in particular to a surface-enhanced Raman spectrum detection method, in which ethanol is added dropwise to a SERS sink bottom containing a target molecule to be measured, and then the signal of the target is detected under a Raman spectrometer. The detection method of the invention can increase the detection limit of the traditional SERS substrate by 104-1010 orders of magnitude, so that Raman spectroscopy can be deeply applied in the field of trace and ultra-trace detection.

Description

[0001] technical field [0002] The invention belongs to an analysis and detection technology, in particular to a surface-enhanced Raman spectrum detection method. Background technique [0003] Raman spectroscopy, like infrared spectroscopy, belongs to molecular vibration spectroscopy, which can reflect the characteristic structure of molecules. However, the Raman scattering effect is a very weak process, and generally its light intensity is only about 10 of the incident light intensity. -10 . Therefore, the Raman signals are very weak, and some kind of enhancement effect is almost always used to study the Raman spectroscopy of surface adsorbed species. When the selected incident laser wavelength is very close to or within the range of electronic absorption peaks of scattering molecules, the probability of Raman transition is greatly increased, making the Raman scattering cross section of some vibrational modes of molecules enhanced up to 10 6 times, this phenomenon ...

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Application Information

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IPC IPC(8): G01N21/65
Inventor 杨良保马永梅马宏伟李民强刘锦淮
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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