Application of β-resorcinol macrolide in prevention and control of harmful snails

A kind of use, the technology of C-6, be used in the field of beta-resorcinolide macrolide

Active Publication Date: 2011-12-07
SOUTH CHINA BOTANICAL GARDEN CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there have been no reports on the use of the above β-resor

Method used

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  • Application of β-resorcinol macrolide in prevention and control of harmful snails
  • Application of β-resorcinol macrolide in prevention and control of harmful snails
  • Application of β-resorcinol macrolide in prevention and control of harmful snails

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the preparation of the compound represented by general formula (1) of the present invention

[0033] Paecilomyces sp.SC0924 CGMCC No.2900 strain was inoculated on 11.50 L of rice solid medium (rice and water at a mass ratio of 1:1), and cultured statically at 26° C. in the dark to obtain a solid fermentation culture. The obtained solid fermentation culture was extracted 3 times with 1.5 times the volume of 95% ethanol for 24 hours each time. After the ethanol aqueous solution was concentrated under reduced pressure to remove ethanol, it was extracted 3 times with an equal volume of chloroform, and the extract was concentrated to obtain a 97.50% chloroform extract. g.

[0034] The chloroform extract was subjected to silica gel column chromatography, and gradient elution was carried out with a mixed solvent of chloroform-methanol with a volume ratio of 100:0 to 80:20, and similar fractions were detected by thin-layer chromatography, and petroleum ether was c...

Embodiment 2

[0046] Embodiment 2: the molluscicidal activity of embodiment 1 compound

[0047] The oncomelania snails used in the experiment were provided by the Jingzhou Center for Disease Control and Prevention in Hubei Province, and the apple snails were collected from the farm of South China Agricultural University.

[0048] The test compound and the positive control tea saponin were dissolved with a small amount of acetone respectively, and diluted with dechlorinated tap water to 20mg / L, 10mg / L and 5mg / L (the final concentration of acetone was less than 0.5% by volume) for the test solution.

[0049] Add 20mL of the above-mentioned different concentrations of the test solution and blank control (dechlorinated tap water with 0.5% acetone added) into a 50mL beaker, put 10 oncomelanias in each beaker, and incubate at room temperature (26°C ± 1°C) for 48h and 48h respectively. 78h to observe the death of Oncomelania snails and apple snails. Observe its activity by tapping method to judge...

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Abstract

The invention relates to application of beta-resorcylic acid large ring lactone expressed through the following general formula (1) in the specification to controlling harmful snails. An indoor molluscicidal drug soaking activity evaluation test indicates that four compounds expressed through the general formula (1) have good molluscicidal activities, wherein when the four compounds are used under the concentration of 10 mg/L for 72 hours, Monocillin II can achieve the molluscicidal rate of more than 95 percent on oncomelania and the molluscicidal rate of more than 70 percent on ampullaria gigas; Radicicol can achieve the molluscicidal rate of more than 75 percent on the oncomelania and the eradicative rate of more than 90 percent on the ampullaria gigas; Monocillin I can achieve the molluscicidal rate of more than 40 percent on the ampullaria gigas; and Monocillin III can achieve the molluscicidal rate of more than 70 percent on the ampullaria gigas.

Description

technical field [0001] The invention relates to a new application of β-resorcinol macrolide, in particular to a new application of β-resorcinolide in the prevention and treatment of harmful snails. Background technique [0002] Snails are a general term for mollusk gastropods, with a wide variety and wide distribution. Many of them can be eaten by people, such as Chinese round snails and square ring or rib snails, or used as feed or bait, such as ear river snails and Big marsh snail, etc. But there are also many snails that are the intermediate hosts of various human or livestock parasites. For example, oncomelania is the intermediate host of Schistosoma japonicum; The intermediate host of fasciola, the round flat snail is the intermediate host of fasciola brucei, etc. Once they are infected, their reproduction and spread will seriously endanger people's health. In addition, there are some snails, such as apple snails, which can reproduce rapidly and excessively, seriously...

Claims

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Application Information

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IPC IPC(8): A01N43/90A01N43/22A01P9/00C12P17/08C12P17/18C12R1/79
Inventor 徐良雄魏孝义薛璟花吴萍游晓莹
Owner SOUTH CHINA BOTANICAL GARDEN CHINESE ACADEMY OF SCI
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