Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for preparing metronidazole injection

A technology for metronidazole sodium chloride and injection, which is applied in the field of preparing metronidazole sodium chloride injection, can solve the problems of white spot of injection, poor stability, easy crystallization of metronidazole, etc., and achieves reduction of adsorption , improve the stability, control the effect of quality

Active Publication Date: 2013-01-09
ANHUI FENGYUAN PHARM CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The metronidazole sodium chloride injection produced by this preparation method is stored at room temperature, and after a long period of storage, metronidazole is easy to crystallize, which will cause white spots in the injection and poor stability.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing metronidazole injection
  • Method for preparing metronidazole injection
  • Method for preparing metronidazole injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Prescription of Metronidazole Sodium Chloride Injection:

[0030] Specification:

[0031] 1 preparation

[0032] 1.1 Pre-production inspection

[0033] 1.2 Picking

[0034] 1.3 Calculation: Calculate the actual feeding amount according to the batch and prescription, and check it.

[0035] Metronidazole actual feed amount (Kg) = Feed amount per liter (Kg) × Dosing amount (L)

[0036] Actual feeding amount of sodium chloride (Kg) = feeding amount per liter (Kg) × liquid dosage (L)

[0037] Actual dosage of activated carbon in concentrated formulation (Kg) = volume (L) × 0.02% (Kg / L)

[0038] Actual dosage of activated carbon (Kg) = volume (L) × 0.01% (Kg / L)

[0039] 1.4 Weighing and carbon adjustment

[0040] Weighing: open the raw and auxiliary materials weighing room to ventilate outside, weigh and check the metronidazole and sodium chloride according to the calculated batch actual feeding amount.

[0041] Carbon adjustment: Open the activated carbon fume hood...

Embodiment 2

[0062] Operate in the same way as in Example 1, the difference is only in:

[0063] Under step 1.5.1, add 1000L water for injection into the concentrated preparation tank, boil and filter back for 15 minutes, send the water for injection into the dilute preparation tank, and filter back for 15 minutes;

[0064] Under step 1.5.2, adsorb on activated carbon for 30 minutes, boil the liquid medicine and keep boiling for 20 minutes, close the steam valve, and cool the temperature of the liquid medicine to 75°C;

[0065] Under step 1.5.3, use a 0.45 μm filter to filter back for 30 minutes, while cooling the liquid medicine to 60°C;

[0066] Under step 2.3, the compressed air bottle washing pressure is 0.4MPa;

[0067] Under step 3.3, sterilize at 120°C for 40 minutes.

[0068] The product batch number is 090731136.

Embodiment 3

[0070] Operate in the same way as in Example 1, the difference is only in:

[0071] Under step 1.5.1, add 1000L water for injection into the concentrated preparation tank, boil for 12 minutes and back-filter, send the water for injection into the dilute preparation tank, and back-filter for 12 minutes;

[0072] Under step 1.5.2, adsorb on activated carbon for 20 minutes, boil the liquid medicine and keep boiling for 15 minutes, close the steam valve, and cool the temperature of the liquid medicine to 50°C;

[0073] Under step 1.5.3, backfilter with a 0.45 μm filter for 30 minutes, while cooling the liquid medicine to 40°C;

[0074] Under step 2.3, the compressed air bottle washing pressure is 0.6MPa;

[0075] Under step 3.3, sterilize at 122°C for 38 minutes.

[0076] The product batch number is 090731137.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for preparing metronidazole injection, which comprises the following steps of: dissolving metronidazole by using water for injection, performing ultrafiltration, mixing metronidazole filtrate and sodium chloride at one time in a thick mixing tank, adding active carbon for adsorption, boiling, cooling for decarbonization, transferring a metronidazole and sodium chloride solution into a thin mixing tank, adding active carbon into the thin mixing tank, filtering, checking, washing bottles, filling, sealing, and sterilizing. The prepared metronidazole injection has high stability, and crystals cannot be separated out and white spots cannot be generated after the metronidazole injection is stored for a long time.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to a method for preparing metronidazole and sodium chloride injection. Background technique [0002] Metronidazole Sodium Chloride Injection is mainly used for the treatment of anaerobic infection, such as anti-amoeba, anti-trichomonas and other anaerobic infection, and its main ingredient is metronidazole. Administration is usually by intravenous infusion. Qualified products are colorless or almost colorless clear liquids. [0003] The existing production process is to separately concentrate metronidazole and sodium chloride, and then combine the liquid medicines. The metronidazole and sodium chloride injection produced by this preparation method is stored at normal temperature, and metronidazole is easy to crystallize after a long time, which will cause white spots in the injection and poor stability. Contents of the invention [0004] The technical problem to be ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08
Inventor 陈彬
Owner ANHUI FENGYUAN PHARM CO LTD