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Method for extracting human chorionic gonadotropin (HCG)

A chorionic gonadotropic and alkaline technology, which is applied in the field of chemical drug extraction technology, can solve the problems of cumbersome process steps, low yield, and large amount of manual operation

Inactive Publication Date: 2012-01-11
SHANDONG TOPSCI BIO TECH
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Problems solved by technology

[0002] Human chorionic gonadotropin is a glycoprotein secreted by the trophoblast cells of the placenta. It is composed of α and β dimer glycoproteins. It is clinically used for functional uterine bleeding, male cryptorchidism, hypogonadism and other diseases , is a commonly used drug with definite curative effect and wide application, so the method of extracting human chorionic gonadotropin is an important biopharmaceutical method. The existing methods for extracting human chorionic gonadotropin generally include benzoic acid adsorption Elution method, kaolin adsorption and elution method, etc. These methods have complicated process steps, large amount of manual operation, long production cycle and low yield

Method used

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Embodiment Construction

[0008] Embodiments of the present invention, the steps are: extract from the urine of pregnant women, add 20% sodium hydroxide to the urine of pregnant women, adjust the pH of the urine of pregnant women to 10.0-10.5, filter through filter paper, and obtain by ultrafiltration with an ultrafiltration machine Concentrate the urine, then add an organic solvent with a content of 95% ethanol, let it stand for 10-16 hours to obtain a precipitate, and dry the precipitate for 8 hours at a temperature of 22-28°C to obtain human chorion gonadotropins.

[0009] In the production of human chorionic gonadotropin in our company, the benzoic acid adsorption method was used before, and only about 40 grams of human chorionic gonadotropin could be extracted per 100 kilograms of pregnant women’s urine. Now about 60 grams of human chorionic gonadotropin can be extracted from every 100 kilograms of pregnant women's urine, thus increasing the yield.

[0010] The present invention has the following...

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Abstract

Belonging to the technological field of chemical drug extraction, the invention discloses a method for extracting human chorionic gonadotropin (HCG). The method comprises the steps of: adjusting the pH value of pregnant woman urine to alkaline, conducting filtration and ultrafiltration so as to obtain concentrated urea, then adding an organic solvent, and leaving the mixture to stand, so that a precipitate can be obtained, and drying the precipitate, thus obtaining the HCG. The method of the invention has the advantages of simplified technology, high product yield, low production cost, and the like.

Description

1. Technical field [0001] The invention relates to a process for extracting chemical drugs, in particular to a method for extracting human chorionic gonadotropin. 2. Background technology [0002] Human chorionic gonadotropin is a glycoprotein secreted by the trophoblast cells of the placenta. It is composed of α and β dimer glycoproteins. It is clinically used for functional uterine bleeding, male cryptorchidism, hypogonadism and other diseases , is a commonly used drug with definite curative effect and wide application, so the method of extracting human chorionic gonadotropin is an important biopharmaceutical method. The existing methods for extracting human chorionic gonadotropin generally include benzoic acid adsorption Elution method, kaolin adsorption and elution method, etc., these methods have complicated process steps, large amount of manual operation, long production cycle and low yield. 3. Contents of the invention [0003] In order to overcome the above-mentio...

Claims

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Application Information

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IPC IPC(8): C07K14/59C07K1/30
Inventor 赵贵吉殷小崴赵文蒙孔令东何西涛
Owner SHANDONG TOPSCI BIO TECH
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