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Implanted retina micro-stimulation electrode chip with drug slow release function

A stimulating electrode, implantable technology, applied in the field of artificial retina

Inactive Publication Date: 2012-02-01
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the deficiency that the microelectrode array cannot work effectively after being implanted in the body for a period of time, the technical problem solved by the present invention is to overcome the traditional electrical stimulation method of artificial retinal microelectrode implantation. After entering the body, the microelectrode cannot normally stimulate the nerve tissue due to the encapsulation of oligodendrocytes and microglia

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  • Implanted retina micro-stimulation electrode chip with drug slow release function
  • Implanted retina micro-stimulation electrode chip with drug slow release function
  • Implanted retina micro-stimulation electrode chip with drug slow release function

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Embodiment Construction

[0023] The present invention will be further described below in conjunction with accompanying drawing and specific embodiment.

[0024] Such as figure 1 with image 3 As shown, an implantable retinal microstimulation electrode chip with drug sustained release function includes an electrode base 1, a microelectrode 2, an electrode inner lead 6, a lead base 7, a lead interface 8 and a lead bundle 9; Displayed and distributed on the surface of the electrode base and protruding from the surface of the electrode base, the electrode base 1 is provided with adjacently distributed annular micro-grooves 3 for drug sustained release, and each micro-electrode 2 is respectively arranged on the ring The center of circle of shape microgroove 3; The surface of this ring-shaped microgroove 3 is coated with medicine slow-release coating, and this medicine releases through microgroove 3 to the biological tissue that electrode chip surface contacts. The radius of the microelectrode 2 is about...

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Abstract

The invention provides an implanted retina micro-stimulation electrode chip with a drug slow release function, which comprises an electrode substrate and micro-electrodes, wherein all micro-electrodes are distributed on the electrode substrate in a display mode and protrude out of the surface of the electrode substrate; annular micro-grooves which are distributed adjacently and are used for drug slow release are arranged on the electrode substrate; each micro-electrode is respectively arranged at the center of a circle of each annular micro-groove; a drug slow release coating is coated on thesurface of each annular micro-groove; and drugs are released to biological tissues on the surface of a micro-electrode chip through the micro-grooves on the micro-electrodes. In the invention, a micro-electrode substrate is used as a platform for carrying drugs, and a polymer carrier is used for controlling the drug slow release time, so that the drugs are released. The drugs can improve the transmission efficiency of neural electric stimulation signals on an electrode-tissue interface and can improve the control on drug slow release directionality. Strip-shaped micro-channels are also arranged on the electrode substrate and are communicated with the annular micro-grooves, and drugs to be slowly released are stored in the strip-shaped micro-channels, thus the drug storage capacity is larger and the life cycle of the drugs is prolonged.

Description

technical field [0001] The present invention relates to the field of artificial retina technology, in particular to an implantable retinal micro-stimulation electrode chip with drug sustained release function. [0002] Background technique [0003] Retinitis pigmentosa RP, age-related macular degeneration (AMD) and other outer retinal degenerative diseases are the main eye diseases that lead to neurological blindness. There is no effective treatment at present, which seriously endangers people's health. Quality of life, and caused a huge social burden. Humayun et al. used histological examination to find that 78.14% of the inner layer neurons were still alive in the retinal tissues of eyes blinded by RP. Chow et al. confirmed in the eyes of animals that the evoked potential responses of the visual cortex could be recorded when the preretinal and subretinal received electrical stimulation. These experimental results indicate that the visual system can be activated by exter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/08A61F2/14A61M31/00A61N1/372
Inventor 王星侯文生刘玮琦阴正勤郑小林姚军平刘娜
Owner CHONGQING UNIV
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