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Layer-by-layer assembled microcapsule and its preparation method

A layer-by-layer assembly and microcapsule technology is applied in the field of layer-by-layer assembly of microcapsules and its preparation, which can solve the problems of easy dissolution, entering the human body, and toxic cross-linking agents, and achieves the effect of good stability.

Active Publication Date: 2012-02-01
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as we all know, most of the above-mentioned cross-linking agents are poisonous, easy to dissolve and enter the human body, thus causing great harm to the human body

Method used

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  • Layer-by-layer assembled microcapsule and its preparation method
  • Layer-by-layer assembled microcapsule and its preparation method
  • Layer-by-layer assembled microcapsule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Preparation of oxidized sodium alginate (ADA) with dialdehyde structure

[0034] 5 g of sodium alginate was prepared into a solution with a concentration of 2.5 wt % with distilled water, 5.4 g of sodium periodate was added to the solution, and an appropriate amount of ethylene glycol was added to stop the reaction after 24 hours of reaction in the dark. The solution was mixed with 10 g of sodium chloride, and the product was precipitated with 200 mL of absolute ethanol, filtered with suction and dissolved in deionized water, and precipitated with ethanol again. ADA can be prepared by vacuum drying for 24h.

[0035] (2) Biocompatible microcapsules based on Schiff base bond assembly

[0036] First, the manganese carbonate particles were dispersed into a 1 mg / mL chitosan (chitosan, CHI) solution containing 0.5 M sodium chloride, and after 30 min of vibration adsorption, centrifuged, washed thoroughly, and then dispersed into a solution containing 0.5 M sodium chlorid...

Embodiment 2

[0039](1) Preparation of dialdehyde cellulose (DAC) with dialdehyde structure

[0040] 5 g of cellulose was prepared into a solution with a concentration of 2.5 wt % with distilled water, 5.4 g of sodium periodate was added to the solution, and an appropriate amount of ethylene glycol was added to stop the reaction after 24 hours of reaction in the dark. The solution was mixed with 10 g of sodium chloride, and the product was precipitated with 200 mL of absolute ethanol, filtered with suction and dissolved in deionized water, and precipitated with ethanol again. The DAC can be prepared by vacuum drying for 24h.

[0041] (2) Biocompatible microcapsules based on Schiff base bond assembly

[0042] First, the polystyrene colloidal particles were dispersed into a 1 mg / mL chitosan (CHI) solution containing 0.5 M sodium chloride, and after 6 h of vibration adsorption, centrifuged, washed thoroughly, and then dispersed into a solution containing 0.5 M chlorine The aldehyde group on ...

Embodiment 3

[0044] (1) Preparation of oxidized starch (dialdehyde starch, DAS) with dialdehyde structure

[0045] 5 g of starch was prepared into a solution with a concentration of 2.5 wt % with distilled water, 5.4 g of sodium periodate was added to the solution, and an appropriate amount of ethylene glycol was added to stop the reaction after 24 hours of reaction in the dark. The solution was mixed with 10 g of sodium chloride, and the product was precipitated with 200 mL of absolute ethanol, filtered with suction and dissolved in deionized water, and precipitated with ethanol again. DAS can be prepared by vacuum drying for 24h.

[0046] (2) Biocompatible microcapsules based on Schiff base bond assembly

[0047] First, the calcium carbonate particles were dispersed in a 5 mg / mL chitosan (CHI) solution containing 0.5 M sodium chloride, and after 30 min of vibration adsorption, centrifuged, washed thoroughly, and then dispersed into a solution containing 0.5 M sodium chloride. The aldeh...

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Abstract

The invention relates to a biologically compatible microcapsule and its preparation method, especially a Schiff base bond based and layer-by-layer assembled biologically compatible microcapsule and its preparation method. The microcapsule is characterized in that the capsule wall consists of biologically compatible and biodegradable polysaccharides and derivatives thereof, and the Schiff base bond forms among the capsule wall components without employing additional cross linking agent. Compared with microcapsules prepared by traditional methods, the microcapsule obtained in the method has the advantages of good stability, biocompatibility, biodegradability, nontoxity, auto-fluorescence and pH responsive permeability, as well as no need for a cross linking agent.

Description

technical field [0001] The purpose of the present invention is to provide a method for assembling biocompatible microcapsules layer by layer based on Schiff base bonds. Background technique [0002] Microcapsules are substances with a specific geometric shape formed by isolating the inner space of the capsule from its outer space by a film-forming substance. . The interior of the microcapsules can be filled or hollow. The capsule wall of the microcapsule is usually composed of natural or synthetic polymer materials or inorganic materials, and the thickness of the capsule wall is generally between several nanometers and several micrometers. The capsule wall of the microcapsule isolates the inner and outer spaces of the capsule. If the substance is wrapped in the capsule, the physicochemical and biological properties of the substance itself will not be affected, and at the same time, it will protect the wrapped substance and separate it from the outside world. isolation. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02A61K9/50A61K47/36A61K47/38
Inventor 李峻柏贾怡费进波崔岳
Owner INST OF CHEM CHINESE ACAD OF SCI
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