Method for preparing cefuroxime-L-arginine hydrate
A technology of cefuroxime acid and cefuroxime, applied in the field of medicine, can solve problems such as instability and easy discoloration, and achieve the effect of improving stability
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example 1
[0033] Process: Dissolve cefuroxime acid in L-arginine aqueous solution, the molar ratio of cefuroxime acid to L-arginine is 5:1, then add into acetone solution for recrystallization, and finally obtain a pharmaceutical compound containing crystal water.
[0034] Detection:
[0035] 1. Elemental analysis (C 22 h 30 N 8 o 10 S·H 2 O): C 42.81%; H 5.21%; N 18.13%; S 5.15%. (Theory: C 42.85%; H 5.23%; N 18.17%; S 5.20%)
[0036] 2. The water content in the material is 2.8~3.5% (theoretical: 2.9%) measured by Karl Fischer method; the result of thermogravimetric analysis shows that it is characteristic of monohydrate.
[0037] 3. Content analysis (HPLC method): the content of cefuroxime was 75.1%; the yield was 65.2%.
[0038] 4. Place the sample at a high temperature of 60°C for 10 days, and take samples to test the color of the sample and the solution at 5 days and 10 days respectively. The results show that the sample is white at 5 days, and the color of the solution is e...
example 2
[0040] Process: Dissolve cefuroxime acid in L-arginine aqueous solution, the molar ratio of cefuroxime acid to L-arginine is 4:1, then add into acetone solution for recrystallization, and finally obtain a pharmaceutical compound containing crystal water.
[0041] Detection:
[0042] 1. Elemental analysis (C 22 h30 N 8 o 10 S·H 2 O): C 42.83%; H 5.22%; N 18.13%; S 5.17%. (Theory: C 42.85%; H5.23%; N 18.17%; S 5.20%)
[0043] 2. The water content in the material is 2.8~3.5% (theoretical: 2.9%) measured by Karl Fischer method; the result of thermogravimetric analysis shows that it is characteristic of monohydrate.
[0044] 3. Content analysis: (HPLC method) the content of cefuroxime was 75.6%; the yield was 72.3%.
[0045] 4. Place the sample at a high temperature of 60°C for 10 days, and take samples to test the color of the sample and the solution at 5 days and 10 days respectively. The results show that the sample is white at 5 days, and the color of the solution is equi...
example 3
[0047] Process: Dissolve cefuroxime acid in L-arginine aqueous solution, the molar ratio of cefuroxime acid to L-arginine is 3:1, then add into acetone solution for recrystallization, and finally obtain a pharmaceutical compound containing crystal water.
[0048] Detection:
[0049] 1. Elemental analysis (C 22 h 30 N 8 o 10 S·2H 2 O): C 41.54%; H 5.20%; N 17.67%; S 5.03%. (Theory: C 41.64%; H 5.40%; N 17.66%; S 5.05%)
[0050] 2. The moisture content in the substance was measured by Karl Fischer method to be 5.5~6.0% (theory: 5.7%); the result of thermogravimetric analysis showed that it was the characteristic of dihydrate.
[0051] 3. Content analysis: (HPLC method) the content of cefuroxime was 73.6%; the yield was 86.8%.
[0052] 4. Place the sample at a high temperature of 60°C for 10 days, and take samples to test the color of the sample and the solution at 5 days and 10 days respectively. The results show that the sample is white at 5 days, and the color of the so...
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