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Ribavirin injection and preparation process thereof

A technology of ribavirin and injection, applied in the field of pharmaceutical preparations, can solve the problems of pH value activated carbon adsorption and the like

Inactive Publication Date: 2012-03-07
HENAN FUREN HUAIQINGTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the pH value also affects the adsorption of activated carbon.

Method used

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Embodiment Construction

[0021] The ribavirin injection provided by the invention is composed of ribavirin, sodium chloride, medicinal charcoal and fresh water for injection. Wherein every 1000ml of said ribavirin injection contains 100g of ribavirin, 9g of sodium chloride, 0.5g of medicinal charcoal, and all the rest are fresh water for injection.

[0022] The production process for producing ribavirin injection of the present invention includes washing ampoule, drying and sterilizing ampoule, preparation, filling and sealing, sterilization leak detection, light inspection, drying, printing and packaging. specifically is:

[0023] 1. To wash the ampoules:

[0024] Ampoules are rough cleaned with purified water by ultrasonic waves and enter the fine cleaning room through the transfer window. The water for injection is filtered with a 0.22um polysulfone filter until the visible foreign matter is qualified for fine washing, and the visible foreign matter is checked and then dried and sterilized.

[0...

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Abstract

The invention provides ribavirin injection and a preparation process thereof, belonging to the field of pharmaceutical preparations. The ribavirin injection provided in the invention comprises ribavirin, sodium chloride, medicinal carbon and fresh injection water; each 1000 ml of the ribavirin injection comprises 100 g of ribavirin, 9 g of sodium chloride and 0.5 g of medicinal carbon, with the balance being fresh injection water. The preparation process for the ribavirin injection in the invention is characterized by comprising the following steps: a, adding sodium chloride into injection water to dissolve sodium chloride, then adding ribavirin and dissolving ribavirin with stirring; b, adjusting the pH value of a solution obtained in step a to 5.0 to 5.3, adding medicinal carbon, homogenizing an obtained mixture with stirring and standing the mixture for 15 min; c, carrying out filtration on a medicinal soup obtained in step b by sequential using a titanium rod filter, a 0.45 mu m cylindrical filter and a 0.22 mu m cylindrical filter. According to the invention, the ribavirin injection has a high content; inspection items of the ribavirin injection like related substances and pyrogen accord with standard requirements for ribavirin injections in Chinese Pharmacopeia, the edition of year 2010, the second part.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and provides a ribavirin injection and a preparation method. Background technique [0002] Ribavirin, also known as ribavirin or ribavirin, is a broad-spectrum antiviral drug. It was listed abroad in the 1970s. Ribavirin developed in my country was launched in the 1980s. Tablets, capsules, sprays, eye drops, oral liquids, injections and ribavirin compound preparations are available. At present, ribavirin is mainly used clinically for the treatment of viral diseases such as viral pneumonia and bronchitis caused by respiratory syncytial virus, and skin herpes virus infection. [0003] Ribavirin can inhibit the growth of respiratory syncytial virus, influenza virus, hepatitis A virus, adenovirus and other viruses in vitro, and its mechanism is not completely clear. Ribavirin did not alter viral adsorption, entry, and uncoating, nor did it induce interferon production. Ribavirin is rapi...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/7056A61P31/12A61J3/00
Inventor 白宗锋朱永杰武东亮
Owner HENAN FUREN HUAIQINGTANG PHARMA
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