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Cell resistance measuring system

A resistance measurement and cell technology, applied in the field of measurement instruments, can solve the problems of inability to measure cell resistance and difficulty in measurement, and achieve the effects of improving electroporation efficiency, improving anti-interference ability, and simplifying circuit structure

Inactive Publication Date: 2012-03-21
UNIV OF SHANGHAI FOR SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Aiming at the problem that current common measurement methods cannot measure cell resistance and the measurement is difficult, the present invention proposes a cell resistance measurement system, which meets the particularity of cell measurement and has high precision, which can be used in life science research and medical research

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Embodiment Construction

[0019] Such as figure 1 The block diagram of the working principle of the cell resistance measurement system is shown. The AC square wave micro-current source circuit applies the AC square wave micro-current signal to the measured cell resistance, and generates an AC square wave proportional to the measured resistance value on the measured cell resistance. Voltage, the voltage is converted into a DC voltage through a precision rectifier circuit, and then sent to the A / D conversion circuit for analog-to-digital conversion to generate a digital quantity proportional to the measured resistance value, which is displayed by the digital display circuit. By adjusting the proportional relationship, the displayed number is consistent with the measured resistance value. The power supply circuit converts a single 9V battery power supply into a dual power supply with a symmetrical output of ±4.5V for use by each circuit.

[0020] Power supply circuit and AC square wave micro current sour...

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Abstract

The invention relates to a cell resistance measuring system. An alternating current square wave micro-current source circuit applies alternating current square wave micro-current signals on a measured cell, and outputs alternating current square wave voltage which is in direct ratio to the resistance of the measured cell; the voltage is changed to be direct-current voltage by a precise rectification current and then is sent into an A / D (analogue / digital) conversion circuit for analogue-to-digital conversion so as to generate digital quantity which is in direct ratio to the resistance of the measured cell and is then sent to a digital display circuit to be displayed; a power supply circuit converts a 9V battery single power supply into a duplicate supply symmetrically outputting plus 4.5V and minus 4.5V to be used by various circuits. With the cell resistance measuring system, the circuit structure is simplified, and the measuring accuracy is enhanced; the influence of the potential of cell membranes on the measurement results is eliminated; the electrolytic action of measuring electrodes is eliminated, and the electroporation efficiency of the cell is enhanced; the reliability and the safety of the system are enhanced; and the anti-inference capacity of an instrument is enhanced, so that the instrument is convenient to use.

Description

technical field [0001] The invention relates to a measuring instrument, in particular to a cell resistance measuring system. Background technique [0002] Cells are the basic unit of life, and the specificity of cells determines the specificity of individuals. Therefore, in-depth research on cells is the key to uncovering the mysteries of life, transforming life and conquering diseases. All animal cells are surrounded by a thin film, called the cell membrane or plasma membrane, which separates the cell contents from the surrounding environment of the cell, enabling the cell to exist relatively independently of the environment. Obviously, in order for a cell to maintain normal life activities, not only the contents of the cell cannot be lost, but also its chemical composition must remain relatively stable, which requires a barrier structure between the cell and its environment; but the cell In the process of continuous metabolism, it needs to get oxygen and nutrients from th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R27/14C12Q1/02
Inventor 王东单纯玉郝丽俊
Owner UNIV OF SHANGHAI FOR SCI & TECH
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