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Preparation process of silver/chitosan composite antimicrobial agents

A compound antibacterial agent and preparation technology, which is applied in the direction of biocides, disinfectants, animal repellants, etc., can solve the problems of easy discoloration, restricted application of silver-based antibacterial agents, and reduced antibacterial performance

Active Publication Date: 2012-03-28
HEFEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the silver-based antibacterial agent has excellent antibacterial properties, due to the active chemical properties of silver ions, it is easy to change color under the action of light, heat, etc., making the silver-based antibacterial agent change from white to brown or black.
Discolored antibacterial agents not only cannot be used in light-colored products, but also have significantly reduced antibacterial properties
Therefore, the discoloration problem of silver-based antibacterial agents seriously restricts its application in a wider range.

Method used

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  • Preparation process of silver/chitosan composite antimicrobial agents
  • Preparation process of silver/chitosan composite antimicrobial agents
  • Preparation process of silver/chitosan composite antimicrobial agents

Examples

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preparation example Construction

[0013] A preparation process of a silver / chitosan composite antibacterial agent, comprising the steps of: ① making carboxymethyl chitosan by reacting chloroacetic acid, sodium hydroxide and chitosan; ② making carboxymethyl chitosan obtained by the above reaction Sugar and silver ions are compounded to obtain a silver / chitosan composite antibacterial agent. The method introduces hydrophilic groups through carboxymethylation of chitosan, improves its water solubility on the basis of retaining the original activity of chitosan, and then combines with silver ions to obtain a composite antibacterial agent. The silver / chitosan composite antibacterial agent prepared by the preparation process can not only solve the problem of easy discoloration of silver antibacterial agents, but also greatly improve the antibacterial properties of chitosan.

[0014] In the step ①, the mass ratio of chitosan to NaOH and chloroacetic acid is 1:2-4:2-4, the reaction temperature is 30-70° C., and the re...

Embodiment 1

[0029] ①Carboxymethyl chitosan was prepared by reacting chloroacetic acid, sodium hydroxide and chitosan, the mass ratio of chitosan to NaOH and chloroacetic acid was 1:2:2, the reaction temperature was 30°C, and the reaction time was 6h .

[0030] ② Then silver nitrate and ethylenediaminetetraacetic acid are complexed in an equimolar ratio, and stirred and reacted at normal temperature and pressure for 10 to 30 minutes. Then the carboxymethyl chitosan of above-mentioned reaction gained is compounded with the silver nitrate after complexation, finally obtains silver / chitosan composite antibacterial agent, the reaction mass ratio of carboxymethyl chitosan and silver nitrate is controlled at 1: 0.01.

Embodiment 2

[0032] ①Carboxymethyl chitosan is produced by the reaction of chloroacetic acid, sodium hydroxide and chitosan, the mass ratio of chitosan to NaOH and chloroacetic acid is 1:3:3, the reaction temperature is 60°C, and the reaction time is 10h .

[0033] ② Then silver nitrate and ethylenediaminetetraacetic acid are complexed in an equimolar ratio, and stirred and reacted at normal temperature and pressure for 10 to 30 minutes. Then the carboxymethyl chitosan of above-mentioned reaction gained is compounded with the silver nitrate after complexation, finally obtains silver / chitosan composite antibacterial agent, the reaction mass ratio of carboxymethyl chitosan and silver nitrate is controlled at 1: 0.03.

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Abstract

The invention mainly aims at providing a preparation process of silver / chitosan composite antimicrobial agents. In order to realize the goal of the invention, the preparation process has the technical scheme that the preparation process of silver / chitosan composite antimicrobial agents comprises the steps that: 1, carboxymethyl chitosan is prepared from chloroacetic acid, sodium hydroxide and chitosan through reaction; and 2, the carboxymethyl chitosan prepared through the reaction is compounded with silver ions to obtain the silver / chitosan composite antimicrobial agents. In order to improve the antimicrobial performance of the chitosan, the chitosan is compounded with the silver according to the processing method, the problem that the color of the silver is easy to change can be solved, and simultaneously, the antimicrobial performance of the chitosan can also be greatly improved.

Description

technical field [0001] The invention relates to a preparation process of a silver / chitosan composite antibacterial agent. Background technique [0002] According to the current scientific and technological knowledge, chitosan is a product of deacetylation of chitin, which is very abundant in nature and widely exists in the shells of shrimps, crabs and insects, as well as in the cell walls of algae and fungi. It is the second largest natural polymer with annual output after cellulose. Chitosan is a copolymer composed of β-(1,4)-2-amino-D-glucose units and β-(1,4)-2-acetamido-D-glucose units. [0003] Chitosan itself has good antibacterial properties, but its antibacterial properties are not as good as silver. Although the silver-based antibacterial agent has excellent antibacterial properties, due to the active chemical properties of silver ions, it is easy to change color under the action of light and heat, which makes the silver-based antibacterial agent change from white...

Claims

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Application Information

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IPC IPC(8): A01N55/02A01N43/16A01P1/00
Inventor 杨本宏刘斌余雪莲
Owner HEFEI UNIV
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