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Preparation method of pH-responsive polymethacrylic acid glyceride

A technology of polyglycerol methacrylate and polyglycerol methacrylate, applied in the field of preparation of pH-responsive polyglycerol methacrylate, achieving strong innovation, applicability, and low cost

Inactive Publication Date: 2012-04-11
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, one of the outstanding disadvantages of dendrimers is that they generally require multi-step organic synthesis and purification.

Method used

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  • Preparation method of pH-responsive polymethacrylic acid glyceride
  • Preparation method of pH-responsive polymethacrylic acid glyceride
  • Preparation method of pH-responsive polymethacrylic acid glyceride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Take a 100ml three-necked flask, blow nitrogen gas for 5-10 minutes, take 0.3g of five-arm (Mn=16000) polyglycidyl methacrylate (S516) into a 100ml three-necked flask, add 20ml of acetonitrile and stir to dissolve, at a temperature of 90 ℃ Under the conditions, add ethylenediamine 10ml, stir and reflux for 12 hours, after the solution is cooled, stop stirring and nitrogen protection, dialyze with deionized water for 48 hours and freeze-dry, which is the target product amino polyglycidyl methacrylate S516- da.

Embodiment 2

[0042] Take a 100ml three-necked flask, blow nitrogen for 5-10 minutes, take 0.3g of five-arm (Mn=16000) polyglycerol methacrylate (S516OH) into a 100ml three-necked flask, add 20ml of N,N-dimethylacetamide and stir Dissolve, inject diluted 0.001g p-toluenesulfonic acid as a catalyst at 70°C, stir for 5-10 minutes, inject dissolved 0.187g succinic anhydride (SA), under nitrogen protection, stir and reflux for 4 hours , heated to 140 °C, continued to stir and reflux for 5 hours, after the solution was cooled, stop stirring and nitrogen protection, dialyzed with deionized water for 48 hours and freeze-dried to obtain the target product carboxypolyglycerol methacrylate S516OH-SA.

Embodiment 3

[0044] Take a 100ml three-neck bottle and vacuumize it, blow nitrogen, repeat three times, and dissolve 0.3g carboxyl polyglycerol methacrylate S516OH-SA (carboxyl substitution rate is 40%) in 20ml N,N-Dimethylacetamide to prepare Solution, injected into the reaction device, at a temperature of 70°C, add 0.002ml of dibutyltin dilaurate as a catalyst, under nitrogen protection, stir for 5-10 minutes, dilute 0.12ml of hexamethylene diisocyanate (HDI) with a solvent , injected into the reaction device, stirred and refluxed for 3 hours under nitrogen protection; after the solution was cooled, stop stirring and nitrogen protection, use diethyl ether as a precipitant, precipitate the product, filter it with suction, dissolve it with a small amount of solvent, and dialyze it with deionized water for 48 Hours, freeze-dried, that is the target product semi-interpenetrating carboxyl polyglycerol methacrylate polymer network S516OH-SA / HDI.

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Abstract

The invention relates to a preparation method of pH-responsive polymethacrylic acid glyceride made of functional groups and polymethacrylic acid glyceride. The functional groups consist of alkaline functional groups, acidic functional groups and semiinterpenetrating polymer network structured functional groups. The preparation method comprises preparation of pH-responsive polymethacrylic acid glyceride with alkaline functional groups, preparation of pH-responsive polymethacrylic acid glyceride with acidic functional groups, and preparation of pH-responsive polymethacrylic acid glyceride with semiinterpenetrating polymer network structured functional groups. The method of the invention applies multi-arm star-shaped structure and interpenetrating polymer network structure in preparing pH-responsive high polymer materials, which have the advantages of simplicity and easy availability, low cost, strong innovativeness and applicability, and can be widely used in material science, biology, medicine, and other fields, specifically in drug controlled release, enzyme immobilization, material separation, chemical machinery, pH sensors, etc.

Description

technical field [0001] The invention belongs to the pH-responsive polymer material preparation technology, in particular to a pH-responsive polyglycerol methacrylate preparation method. Background technique [0002] The so-called pH-responsive polymer material refers to a polymer material that can produce volume or shape changes due to changes in pH. Generally, pH-responsive polymers generally contain acidic (such as carboxyl, sulfonic acid) or basic (such as amine) functional groups, which can produce changes in the intramolecular or intermolecular forces of the polymer depending on the change in pH value, thereby It shows the change of various properties of the polymer on the macroscopic scale. The application prospects of pH-sensitive polymer materials are broad, and can be used in materials science, biology, medicine and other fields. Specific applications include drug controlled release, enzyme immobilization, material separation, chemical machinery, pH sensors, etc. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F20/32C08F8/32C08F8/14C08G18/62
Inventor 高辉顾文星马亚男陆学友马建标
Owner TIANJIN UNIVERSITY OF TECHNOLOGY