Method for synthesizing (R,S)1-bromoethyl acetate

A technology of ethyl acetate and bromination, applied in the field of cefuroxime axetil key intermediate (R field, can solve the problems of increasing the amount of acidic waste water, increasing the three wastes, complicated operations, etc., reducing the discharge of the three wastes, facilitating control, Simple to use effects
CN102417451AActive Publication Date: 2012-04-18ZHEJIANG GUOBANG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG GUOBANG PHARMA
Publication Date
2012-04-18

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Abstract

The invention relates to a method for synthesizing (R,S)1-bromoethyl acetate. The method comprises the following steps of: dissolving acetaldehyde and acetyl bromide into a solvent, and reacting in the presence of a catalyst with a naphthalene ring structure to obtain the (R,S)1-bromoethyl acetate. By the method, the content and yield of the (R,S)1-bromoethyl acetate are remarkably improved; the process is simple and can be operated stably; three wastes (waste gas, waster water and industrial residues) are reduced; the cost is reduced; the content and yield of cefuroxime axetil are remarkably improved when the method is applied to the production; and the method is suitable for industrialized production.
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Description

technical field

[0001] The invention relates to a preparation method of (R, S) 1-bromoethyl acetate, a key intermediate of cefuroxime axetil, and belongs to the technical field of preparation of cephalosporin drug intermediates and other compounds. Background technique

[0002] (R, S) 1-Bromoethyl acetate is an important intermediate in the synthesis of cephalosporin drug - cefuroxime axetil. Because the raw materials used and its own properties are quite active, it is easy to be destroyed and the preparation is high. The content of (R, S) 1-bromoethyl acetate is more difficult, which greatly affects the quality and process stability of cefuroxime axetil. Its main synthetic routes are:

[0003] 1. Using zinc chloride as a catalyst, it is prepared by reacting acetyl bromide with paraldehyde, then extracting with dichloromethane, washing with water, and recovering the dichloromethane to dryness under reduced pressure. (EP9993727)

[0004]

[0005] The above-mentioned rou...

Claims

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