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Method for preparing gold-coated magnetic composite nanoparticles

A composite nanoparticle, gold-clad technology, which is applied in the fields of inorganic material magnetism, ferrous oxides, NMR/MRI contrast agents, etc., can solve the problem of narrow spectral controllable range, low magnetic content and complex preparation process and other problems, to achieve the effect of adjustable magnetic content, simple preparation method and adjustable absorption spectrum

Inactive Publication Date: 2012-05-02
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The advantage of this method is that the gold shell is continuous; the disadvantage is that the preparation process is complicated, the magnetic content is low, and the adjustable range of the spectrum is narrow.

Method used

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  • Method for preparing gold-coated magnetic composite nanoparticles
  • Method for preparing gold-coated magnetic composite nanoparticles
  • Method for preparing gold-coated magnetic composite nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Preparation of hydrophobic magnetic nanoparticles (1)

[0021] Add 0.023mol of Fe to 50mL of water that has been passed through nitrogen 3+ and 0.0115mol of Fe 2+ A mixed solution was obtained. Get 200mL of water in a 500mL reaction flask and pass through nitrogen to remove oxygen, add 10mL of mass percent concentration successively as 25% concentrated ammonia and 5.4g oleic acid, quickly pour the above-mentioned iron salt mixed solution into it under vigorous stirring, React at 50°C for 1h. After the reaction is completed, adjust the reaction solution to acidity with hydrochloric acid, separate the black solid from the reaction solution with a 0.1T permanent magnet, and wash the obtained solid with high-purity water for 3 to 5 times to obtain the hydrophobic Fe 3 o 4 Nanoparticles.

[0022] Will Fe 3+ and Fe 2+ respectively replaced by Co 3+ and Co 2+ , the hydrophobic Co can be obtained 3 o 4 Nanoparticles.

Embodiment 2

[0023] Embodiment 2: Preparation of hydrophobic magnetic nanoparticles (2)

[0024] Add 0.023mol of Fe to 50mL of water that has been passed through nitrogen 3+ and 0.0115mol of Fe 2+ A mixed solution was obtained. Take 200mL of water in a 500mL reaction bottle to pass through nitrogen to remove oxygen, add 10mL of concentrated ammonia water with a mass percentage concentration of 25% and 2.76g of myristic acid in turn, and quickly pour the above mixed solution into it under vigorous stirring, and heat it at 80°C Under reaction 1h. Oxygen was then bubbled into the reaction solution for 1.5 h. After the reaction is completed, adjust the reaction solution to acidity with hydrochloric acid, separate the red solid from the reaction solution with a 0.1T permanent magnet, and wash the obtained solid with high-purity water for 3 to 5 times to obtain hydrophobic γ-Fe 2 o 3 Nanoparticles.

Embodiment 3

[0025] Embodiment 3: Preparation of hydrophobic magnetic nanoparticles (3)

[0026] Add 0.023mol of Fe to 50mL of water that has been passed through nitrogen 3+ and 0.0115mol Co 2+ to obtain a mixed solution. Take 200mL of water in a 500mL reaction flask and pass through nitrogen to remove oxygen, add 10mL of concentrated ammonia water with a mass percentage concentration of 25% and 0.665g of 10-undecylenic acid in turn, and quickly pour the above mixed solution into it under vigorous stirring , reacted at 90°C for 1h. After the reaction is completed, adjust the reaction solution to acidity with hydrochloric acid, separate the black solid from the reaction solution with a 0.1T permanent magnet, and wash the obtained solid with high-purity water for 3 to 5 times to obtain CoFe 2 o 4 Hydrophobic nanoparticles.

[0027] Will Co 2+ replace with Mn 2+ , the hydrophobic MnFe can be obtained 2 o 4 Nanoparticles.

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Abstract

The invention discloses a method for preparing gold-coated magnetic composite nanoparticles, and belongs to the technical field of multifunctional composite nanoparticles. The method comprises the following steps of: dissolving hydrophobic magnetic nanoparticles in cyclohexane to serve as an oil phase; dissolving a gold-philic surfactant in de-ionized water to serve as a water phase; ultrasonically mixing; then protecting a volatile solvent with nitrogen to obtain magnetic aggregate aqueous solution of which the surface is modified by the gold-philic surfactant; secondly, adding chloroauric acid, a reducing agent and a stabilizing agent into the magnetic aggregate aqueous solution; and reacting to obtain gold shell-covered magnetic aggregate composite nanoparticles. In the method, a gold shell is directly grown on the surface of a magnetic aggregate; and the nanoparticles have the advantages of continuous adjustable gold shell, adjustable adsorption spectrum, adjustable magnetic content, simple preparation method and the like.

Description

technical field [0001] The invention belongs to the technical field of multifunctional composite nanoparticles, and in particular relates to a simple preparation method of gold-coated magnetic nanoparticles. Background technique [0002] The structure of the gold-coated magnetic composite nanoparticle includes a magnetic aggregate core and a gold shell. Gold-coated magnetic core-shell composite nanoparticles have a very wide range of applications in many fields. As we all know, magnetic nanoparticles have a wide range of applications, such as cell separation, drug delivery, biological separation, enzyme or protein labeling, biosensors, etc. However, bare magnetic nanoparticles have disadvantages such as easy oxidation, aggregation, and decomposition, which greatly limit their application range. The preparation of protective shells on the surface of magnetic nanoparticles is the main method to overcome these defects. Among many protective materials, Au has attracted much a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/01C01G49/08C01G51/04A61K49/06A61K49/18
Inventor 杨文胜金秀梅梁经纶庄家骐杨春凤薛峥
Owner JILIN UNIV
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