Lanthanum carbonate hydrate, preparation method thereof and method for judging whether alkali lanthanum carbonate is doped in lanthanum carbonate

A technology of lanthanum carbonate hydrate, lanthanum carbonate, applied in chemical instruments and methods, rare earth metal compounds, material analysis using radiation diffraction, etc. and other problems, to achieve the effect of simple operation, accurate and reliable results

Inactive Publication Date: 2012-05-09
PEKING UNIV +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the lanthanum carbonate sample produced by the existing method has relatively large particles, most of which are 3-4 μm. Larger particles will result in a relatively small surface area, and the effe

Method used

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  • Lanthanum carbonate hydrate, preparation method thereof and method for judging whether alkali lanthanum carbonate is doped in lanthanum carbonate
  • Lanthanum carbonate hydrate, preparation method thereof and method for judging whether alkali lanthanum carbonate is doped in lanthanum carbonate
  • Lanthanum carbonate hydrate, preparation method thereof and method for judging whether alkali lanthanum carbonate is doped in lanthanum carbonate

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] First add 50mL lanthanum chloride aqueous solution to the flask, its La 3+ The concentration is 2mol / L, and the pH is 0-2. At the beginning, first quickly add 10 mL of sodium bicarbonate aqueous solution to the aqueous solution of lanthanum chloride at a time, and its concentration is 1 mol / L. 2 (CO 3 ) 3 precipitation. Then add sodium bicarbonate solution to the lanthanum chloride solution at a speed of 0.08mL / s until the pH value shows an inflection point, and the reaction stops when the pH value rises abruptly, and a total of 320mL of sodium bicarbonate solution is added. figure 2 The time-pH curve of the preparation of lanthanum carbonate octahydrate by the direct method is given.

[0079] The filtrate was suction filtered, washed three times with distilled water, and the filter cake was placed in a ventilated place to dry naturally.

[0080] image 3 A comparison of the obtained lanthanum carbonate octahydrate (labeled 03-25) with the standard card (25-1400)...

Embodiment 2

[0102] First add 50mL lanthanum chloride aqueous solution to the flask, its La 3+ The concentration is 2.5mol / L and the pH is 1.5. At the beginning, first quickly add 15mL sodium bicarbonate aqueous solution to the lanthanum chloride aqueous solution at a time, and its concentration is 0.81mol / L. At this time, the pH value of the solution rises to about 3. 2 (CO 3 ) 3 precipitation. Then add sodium bicarbonate solution to the lanthanum chloride solution at a rate of 2 mL / s until the pH value shows an inflection point, and the reaction stops when the pH value rises abruptly, and a total of 380 mL of sodium bicarbonate solution is added. The filtrate was suction filtered, washed three times with distilled water, and the filter cake was placed in a ventilated place to dry naturally.

[0103] image 3 A comparison of the obtained lanthanum carbonate octahydrate (labeled 02-23) with standard cards (25-1400) is given. It can be seen that the peak positions are basically the sa...

Embodiment 3

[0110] First add 50mL lanthanum chloride aqueous solution to the flask, its La 3+ The concentration is 1.5mol / L, and the pH is 1.0. At the beginning, first quickly add 8 mL of sodium bicarbonate aqueous solution to the aqueous solution of lanthanum chloride at a time, and its concentration is 1.51 mol / L. 2 (CO 3 ) 3 precipitation. Then add sodium bicarbonate solution to the lanthanum chloride solution at a rate of 1.5 mL / s until the pH value shows an inflection point, and the reaction stops when the pH value rises abruptly, and 260 mL of sodium bicarbonate solution is added in total. The filtrate was suction filtered, washed three times with distilled water, and the filter cake was placed in a ventilated place to dry naturally.

[0111] Put the obtained lanthanum carbonate octahydrate in an oven, keep it at a certain temperature under normal pressure for 20 hours, and obtain lanthanum carbonate with 3 to 4 water, specifically, when the temperature is 50°C, you can get The...

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Abstract

The invention relates to a preparation method of a lanthanum carbonate hydrate, which comprises the steps of: 1) adding a sodium bicarbonate solution into a lanthanum chloride solution to prepare a lanthanum carbonate octahydrate; and 2) dehydrating at a normal pressure and a temperature of 40-120 DEG C to prepare steady lanthanum carbonate containing 1-4 water. The invention also relates to the lanthanum carbonate octahydrate La2(CO3)3.8H2O and lanthanum carbonate containing 1-4 water La2(CO3)3.xH2O obtained by the preparation method (wherein x is in a range from 1 to 4) and an application of the lanthanum carbonate hydrate in preparation of drugs which are used for treating hyperphosphatemia. The invention also relates to a method for judging whether alkali lanthanum carbonate is doped in the lanthanum carbonate by calculatinga molar ratio of carbon to lanthanum in a lanthanum carbonate sample.

Description

technical field [0001] The present invention relates to a kind of preparation method of lanthanum carbonate hydrate, and the octahydrate lanthanum carbonate La obtained by this preparation method 2 (CO 3 ) 3 ·8H 2 O, lanthanum carbonate La containing 1 to 4 water 2 (CO 3 ) 3 ·xH 2 O (wherein x is between 1-4), the present invention also relates to a method for judging whether lanthanum carbonate is mixed with basic lanthanum carbonate. Background technique [0002] Chronic kidney disease is a common public health problem all over the world. One of its main complications is hyperphosphatemia caused by the inability of the kidneys to excrete phosphate in the body, resulting in elevated phosphate levels in the blood. The symptoms of hyperphosphatemia are mainly blood phosphate levels that exceed normal levels, and may be related to secondary hyperparathyroidism, metabolic bone disease, soft tissue calcification, and cardiovascular calcification. [0003] At present, the...

Claims

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Application Information

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IPC IPC(8): C01F17/00G01N23/20G01N21/78G01N21/35G01N21/33G01N23/22G01N21/3563
Inventor 张应贺安琪杨波叶放林扬白翔李钦孙燕林子煌魏永巨刘翠格徐怡庄吴瑾光
Owner PEKING UNIV
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