Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method for L-(+)-tartaric acid

A technology of tartaric acid and potassium iodate, applied in the preparation of carboxylic anhydrides, organic chemistry, etc., can solve the problems of complex process, high product cost, and insufficient market competitiveness, and achieve the effect of mild reaction conditions and easy control

Active Publication Date: 2012-05-16
ZHEJIANG GENEBEST PHARMA
View PDF4 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method uses a biochemical method for chiral hydrolysis, and requires some extreme reaction conditions, such as freezing and resin separation, which have high requirements for operation, and the process is relatively complicated, which makes the product cost high and industrialization is difficult; in addition , the invention of Publication No. CN101736040A discloses a preparation method of L(+)potassium hydrogen tartrate, using potassium epoxy succinate as raw material, and the immobilized cell granule microorganism obtained by fermentation of Nocardia strain Catalyst, the reaction generates the corresponding L(+) potassium tartrate, but the strain used in this method is relatively special, and the cultivation and use requirements of the strain are relatively high, so the production requires high equipment and personnel quality, and the raw materials are also relatively expensive. The market competitiveness of the final product is not enough

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method for L-(+)-tartaric acid
  • Preparation method for L-(+)-tartaric acid
  • Preparation method for L-(+)-tartaric acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A. Preparation of Crude Product of (2R,3S)-2,3-Dihydroxysuccinic Anhydride

[0026] Add maleic anhydride (98g, 1.0mol), distilled water (980g) and catalyst sodium tungstate (1.9g) into the reactor, stir well and then add potassium iodate (129g, about 0.60mol) and iodine (152g , about 0.60mol), then heated to 105°C under stirring, refluxed for 6 hours, the reaction was completed, cooled to room temperature, filtered to collect the precipitated solid, and dried to obtain (2R,3S)-2,3-dihydroxybutanedi The crude acid anhydride (containing part of L-(+)-tartaric acid), about 68.6g, was directly used in the next reaction.

[0027] B. Preparation of L-(+)-tartaric acid

[0028] Add crude (2R,3S)-2,3-dihydroxysuccinic anhydride (100g) and sulfuric acid solution (800g) with a mass fraction of 20% into the reactor, heat to 105°C under stirring conditions, and keep stirring for 6 hour, then cooled to room temperature, crystals were precipitated, collected by filtration, and dr...

Embodiment 2

[0030] The other steps of this embodiment are the same as in Example 1, except that the preparation method of the crude product of (2R,3S)-2,3-dihydroxysuccinic anhydride in step A is as follows:

[0031] Add maleic anhydride (98g, 1.0mol), distilled water (588g) and catalyst sodium tungstate (1g) into the reactor, stir well and then add potassium iodate (107g, about 0.50mol) and iodine (127g, about 0.50mol), then heated to 100°C under stirring, and refluxed for 4 hours. After the reaction was completed, cooled to room temperature, filtered to collect the precipitated solid, and dried to obtain (2R,3S)-2,3-dihydroxysuccinic anhydride The crude product (containing part of L-(+)-tartaric acid), about 57.4g, was directly used in the next reaction.

Embodiment 3

[0033] The other steps of this embodiment are the same as in Example 1, except that the preparation method of the crude product of (2R,3S)-2,3-dihydroxysuccinic anhydride in step A is as follows:

[0034] Add maleic anhydride (98g, 1.0mol), distilled water (600g) and catalyst potassium tungstate (1g) into the reactor, stir well and then add potassium iodate (118g, about 0.55mol) and iodine (140g, about 0.55mol), then heated to 105°C under stirring, refluxed for 6 hours, the reaction was completed, cooled to room temperature, filtered to collect the precipitated solid, and dried to obtain (2R,3S)-2,3-dihydroxysuccinic anhydride The crude product (containing part of L-(+)-tartaric acid), about 62.3g, was directly used in the next reaction.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method for L-(+)-tartaric acid, relating to the field of chemical synthesis. The invention uses maleic anhydride as raw material and performs oxidization reaction on the maleic anhydride by a composite oxidant of potassium iodate and iodine in the presence of a catalyst, and performs a hydrolysis reaction in the presence of strong acid to obtain the L-(+)-tartaric acid. The preparation method provides a new way to directly prepare chiral L-(+)-tartaric acid through a selective oxidation reaction, wherein reaction conditions in all steps are easy to operate, and the technology is simple, and reactions in all steps are of comparatively normal operation. In addition, the preparation method avoids using particular requirements on strain cultivation and use in the biological method, and lowers the cost of the product.

Description

technical field [0001] The invention relates to the field of chemical synthesis, in particular to a preparation method of L-(+)-tartaric acid, a resolving agent widely used in the field of pharmaceutical synthesis. Background technique [0002] Tartaric acid is an important organic raw material, which can be widely used as an acidulant for beverages and other foods, and generally exists in the fruits of various plants in the form of potassium salts. Potassium hydrogen tartrate is also an internationally recognized non-toxic food additive. In addition, chiral tartaric acid is also a resolving agent used in organic synthesis reactions. In recent years, its role in the field of pharmaceutical synthesis has become more and more obvious, and the economic benefits of chiral tartaric acid have also become increasingly apparent. [0003] In the known literature, there are many methods for preparing tartaric acid, which are generally prepared by biological fermentation and catalytic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C59/255C07C51/087
Inventor 宋苗根王金银
Owner ZHEJIANG GENEBEST PHARMA