Synthetic method of antimicrobial medicament
A synthesis method and technology of antibacterial drugs, applied in the field of synthesis of antibacterial drugs, can solve problems such as harsh synthesis conditions and unfavorable industrial production, and achieve the effect of simple synthesis steps and low requirements for synthesis conditions
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[0024] The synthetic steps of the present invention are:
[0025] 1.3 Synthesis of m-fluorophenyl 2-oxo-5-oxazolidinyl chloride
[0026] The reaction equation is:
[0027]
[0028] 2.3 Synthesis of m-fluorophenyl 2 oxo 5 oxazolidine azidomethane
[0029] The reaction equation is:
[0030]
[0031] 3.3 Synthesis of m-fluorophenyl 2-oxo-5-oxazolidinylmethylacetamide
[0032] The reaction equation is:
[0033]
[0034] 4.3 Synthesis of (3' fluoro 4' bromo) phenyl 2 oxo 5 oxazolidinylmethylacetamide
[0035] The reaction equation is:
[0036]
[0037] 5. Synthesis of linezolid
[0038] The reaction equation is:
[0039]
[0040] The drug intermediate and final product of the present invention have been confirmed by NMR and mass spectrograms.
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