New compound in secondary metabolites of cephalotaxus fortunei endophytic fungi, and preparation method and application thereof

A compound and drug technology, applied in the field of medicine, can solve problems such as being endangered

Inactive Publication Date: 2012-05-23
MICROSCREEN BIOTECH SHANGHAI
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  • New compound in secondary metabolites of cephalotaxus fortunei endophytic fungi, and preparation method and application thereof
  • New compound in secondary metabolites of cephalotaxus fortunei endophytic fungi, and preparation method and application thereof
  • New compound in secondary metabolites of cephalotaxus fortunei endophytic fungi, and preparation method and application thereof

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[0085] The present invention will be further elaborated below in conjunction with the accompanying drawings and specific embodiments. These examples should be understood as only for illustrating the present invention but not for limiting the protection scope of the present invention. After reading the contents of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent changes and modifications also fall within the scope defined by the claims of the present invention.

[0086] The following preferred embodiments of the present invention study the new compound Trichodermanin B isolated from the endophytic fungus Trichoderma atrovirid S361 and its fermentation product and its pharmacological action, and provide a kind of compound that can be used to prepare antifungal, antifungal Viruses, raw materials for anti-tumor products, lay the foundation for the development of new active drugs.

[0087](1) P...

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Abstract

The invention discloses a compound Trichodermanin B with the following structural formula, which is separated and prepared from a cephalotaxus fortunei endophytic fungi Trichoderma atroviride as a source. The molecular formula of the compound is C15H28O3 and the molecular weight is 256. The invention also discloses a preparation method for the compound. In vivo experiments show that the compound has certain fungi resistant, anti-virus and tumor resistant activities. The invention lays a foundation for the development of new active medicaments.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a novel compound in a fermentation product of an endophytic fungus of Cephalotaxus fortunei, that is, a novel compound in a fermentation product of an endophytic fungus of the genus Trichoderma Trichoderma atroviride Compound Trichodermanin B; in addition, the present invention also relates to the preparation method of the compound and the use of Trichodermanin B. Background technique [0002] Endophytic fungi refer to fungi that exist in healthy plant tissues during a certain stage or the entire stage of their life history, without causing obvious diseases to plant tissues or causing obvious damage to the host. About 400 plant species of endophytic fungi have been studied in the world. Since 1993, an endophytic fungus producing anticancer substance paclitaxel was isolated from the phloem of Taxus brevifolia. There are more than 110 species of medicinal plants in 47 families i...

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Application Information

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IPC IPC(8): C07D307/00C12P17/06A61K31/343A61P31/10A61P31/12A61P35/00A61P35/02A61P31/22C12R1/885
Inventor 郑承剑孙培欣韩婷马文辉孙慧
Owner MICROSCREEN BIOTECH SHANGHAI
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