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Application of oxazole compound in fluoride ion detection

An isoxazole and compound technology, applied in the fields of organic chemistry, fluorescence/phosphorescence, material excitation analysis, etc., can solve the problems of kidney damage, bone and tooth damage, urinary calculi, etc., and achieve the effect of high selectivity and good sensitivity

Active Publication Date: 2013-08-21
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, excessive intake of fluoride ions can also cause damage to bones and teeth, and even damage the kidneys, as well as cause urinary stones

Method used

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  • Application of oxazole compound in fluoride ion detection
  • Application of oxazole compound in fluoride ion detection
  • Application of oxazole compound in fluoride ion detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 13

[0030] Example 13-Amino-5-(4,5,6,7-tetrahydro-1H-indol-2-yl)isoxazole-4-amide (acceptor 1) ability to recognize fluoride ions in acetonitrile

[0031] 1) Dissolve acceptor 1 in acetonitrile to make 5×10 -6 mol L -1 solution; measure the UV-visible absorption spectrum of the solution between 300-420nm, and measure the fluorescence spectrum of the solution when the excitation wavelength is 340nm;

[0032] 2) Take 7 parts (5ml each) of the above solution, add tetrabutylammonium fluoride, tetrabutylammonium chloride, tetrabutylammonium bromide, tetrabutylammonium iodide, tetrabutylammonium bisulfate, The acetonitrile solution of tetrabutylammonium dihydrogen phosphate and tetrabutylammonium acetate makes the concentration of tetrabutylammonium salt be 50 times of acceptor 1 after adding, measure respectively the ultraviolet-visible absorption spectrum and this moment of these 7 parts of solutions The fluorescence spectrum when the excitation wavelength is 340nm; the results are ...

Embodiment 2

[0035] Embodiment 2 detects the method for fluoride ion in acetonitrile solution:

[0036] 1) Dissolve acceptor 1 in acetonitrile to make 5×10 -6 mol L -1 The solution;

[0037] 2) Take 5ml of the above solution, add the acetonitrile solution of tetrabutylammonium fluoride dropwise, and gradually increase the concentration, so that the concentration of tetrabutylammonium fluoride after adding is 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18, 20, 25, 30, 35, 40, 45, 50 times, measure each moment respectively The fluorescence spectrum when the excitation wavelength is 340nm is made into a standard titration curve (such as Figure 5 shown);

[0038] 3) Get 5ml of the solution in step 1), add dropwise 1-100 μl of acetonitrile solution containing fluoride ions of unknown concentration, measure the fluorescence spectrum when the excitation wavelength is 340nm at this time, compare the fluorescence spectrum obtained with the standard titration curve, Obt...

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Abstract

The invention provides an oxazole compound which can serve as a chemical sensor for identifying fluoride ions, such as 3-amino-5-(4,5,6,7-tetrahydrophthalic anhydride -1H-indole-2-base) oxazole -4-glutamine. According to the invention, the oxazole compound serves as a receptor, so that the selectivity to the fluoride ions is high, and the sensitivity is good.

Description

technical field [0001] The present invention relates to an isoxazole compound having the use for detecting fluoride ions, and also relates to the use of the isoxazole compound as a chemical sensor for identifying fluoride ions. Background technique [0002] Fluoride ion is the smallest anion. Compared with other anions, fluoride ion has special electrical properties. The most prominent is its impact on the ecological environment and biological health. Fluoride ions exist in water, toothpaste and various medicines, and can be used to prevent dental diseases and treat osteoporosis. However, excessive intake of fluoride ions can also cause damage to bones and teeth, and even damage the kidneys, as well as lead to urinary stones. Therefore, the detection of fluoride ions has always been the focus of attention. Traditional detection methods include ion-selective electrodes and 19 F NMR spectroscopy, but it is also important to design corresponding chemical sensors, especially ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64C07D413/04
Inventor 杨国强杨志培李沙瑜王双青马金石胡睿田凯军冯娇熊磊
Owner INST OF CHEM CHINESE ACAD OF SCI