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Magnetic carbon nanotube based biodetection

A technology of carbon nanotubes and magnetic materials, applied in carbon nanotubes, biological testing, nanotechnology for sensing, etc., can solve problems such as complex surface functionalization

Inactive Publication Date: 2012-05-23
NANOMIX
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Although magnetic beads have been used in a variety of bioassay applications, they often involve complex surface functionalization

Method used

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  • Magnetic carbon nanotube based biodetection
  • Magnetic carbon nanotube based biodetection
  • Magnetic carbon nanotube based biodetection

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[0057] CNTs were grown in anodized alumina templates by chemical vapor deposition (CVD). The CNT diameter is easily controlled by the template pore size. Electrochemical deposition is then used to form ferromagnetic nanoparticles inside the nanotubes (mCNTs). Study the bulk behavior of thousands of embedded magnetic nanoparticles and their ability to impart strong paramagnetic behavior to CNTs. The results indicate that mCNTs indicate that embedded magnetic nanoclusters are sufficient to provide excellent separation characteristics. Figure 6 is an image of mCNTs isolated from bulk solution using a permanent magnet. The mCNTs were in ultrapure water and were separated from solution using a permanent magnet (marked) placed behind a glass vial. In contrast, non-magnetic CNTs will settle to the bottom of the vial.

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Abstract

Provided herein is a new hybrid material system, mCNT, including magnetic carbon nanotubes for biological and medical sensing applications. In certain embodiments, the systems include magnetic material on the interior of carbon nanotubes (CNTs). The amount of magnetic particles inside CNTs may be such that mCNT can respond to small, low cost, portable magnet. The exterior CNT surface is kept intact for biomolecular attachments or other functionalizations. Performance enhancement with this novel material includes improved sensitivity, reduced response time, and reduced sample volume. According to various embodiments, the mCNTs are substrates for the adherence of molecules participating in these assays or as active sensing elements. Also provided are methods of fabricating two-dimensional mCNT and CNT networks on printed electrodes.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Patent Application No. 61 / 232,242, filed August 7, 2009, under 35 USC. §119(e). This application is incorporated herein by reference. technical field Background technique [0003] An electrochemical immunosensor based on a single-walled CNT forest platform combined with a multi-labeled secondary antibody nanotube bioconjugate has been reported as a highly sensitive detection platform. (Xin (Xin) et al., "Carbon Nanotube Amplification Strategies for Highly Sensitive Immunodetection of Cancer Biomarkers", Journal of the American Chemical Society Society) 2006128(34), pp. 11199-11205, which is incorporated herein by reference). In this case, SWNT forests stand in vertical bundles on a Nafion-iron oxide decorated conductive surface. Sensitivity amplification was achieved by replacing the single-labeled secondary antibody with a bioconjugate of horseradish peroxidase...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B82B3/00C01B31/02G01N33/53G01N27/30
CPCC01B31/0226G01N27/226C01B31/0233B82Y15/00G01N33/5438G01N33/5434C01B31/0273B82Y40/00G01N33/54333G01N33/54326B82Y30/00G01N2446/00C01B32/16C01B32/162C01B32/174
Inventor 干乍恩·乔希张英兰布拉德利·N·约翰逊雷·拉特凯
Owner NANOMIX
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