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Medicinal composition for treating coronary disease and angina pectoris, preparation method thereof and preparation thereof

A technology for coronary heart disease angina pectoris and a composition is applied in the field of a pharmaceutical composition for treating coronary heart disease angina pectoris, a preparation method and a preparation field thereof, and can solve the problems of insufficient extraction of active ingredients, insufficient utilization of medicinal residues, and no preparation method provided. , to achieve the effect of significant curative effect, improved yield and reduced extraction time

Active Publication Date: 2013-12-25
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Among the above preparation methods, the monarch drug Migao only uses steam distillation to extract the volatile oil, which takes a long time and has a low yield. Ligusticum chuanxiong only adopts the method of alcohol extraction, the extraction of active ingredients is insufficient, and the utilization rate of medicinal materials is low
Therefore, the above-mentioned process is not perfect enough, and a set of overall effective preparation method is not given to obtain a drug extract with high active ingredients

Method used

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  • Medicinal composition for treating coronary disease and angina pectoris, preparation method thereof and preparation thereof
  • Medicinal composition for treating coronary disease and angina pectoris, preparation method thereof and preparation thereof
  • Medicinal composition for treating coronary disease and angina pectoris, preparation method thereof and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Embodiment 1: the preparation of dropping pill

[0106] Migao 450g, Borneol 9g, Chuanxiong 360g, Scallion 36g

[0107] The preparation process is:

[0108] (1) Migao is crushed into coarse powder, passed through a 24-mesh sieve, soaked in 8 times the amount of 75% ethanol, soaked for 7 hours, ultrasonically extracted for 80 minutes, filtered with suction, and the filtrate was collected, and the solvent in the filtrate was evaporated by steam , to obtain Migao volatile oil and dregs for subsequent use;

[0109] (2) Ligusticum chuanxiong is crushed into coarse powder, passed through a 24-mesh sieve, soaked in 10 times the amount of 70% ethanol for 2 hours, heated and refluxed 3 times, and the extraction time is 3 hours each time. The amount of ethanol used for the second and subsequent times is the weight of the medicinal material 8 times, filter, combine the filtrate, concentrate the filtrate to a relative density of 1.15-1.25 under the condition of 50-70°C, add ethano...

Embodiment 2

[0114] Embodiment 2: the preparation of dropping pill

[0115] Migao 550g, borneol 11g, chuanxiong 440g, scallion 44g

[0116] The preparation process is:

[0117] (1) Migao is crushed into coarse powder, passed through a 24-mesh sieve, soaked in 5 times the amount of 95% ethanol, soaked for 5 hours, ultrasonically extracted for 75 minutes, filtered with suction, and the filtrate was collected, and the solvent in the filtrate was evaporated by steam , to obtain Migao volatile oil and dregs for subsequent use;

[0118] (2) Ligusticum chuanxiong is crushed into coarse powder, passed through a 24-mesh sieve, soaked in 10 times the amount of 80% ethanol for 3 hours, heated and refluxed 3 times, each extraction time is 4 hours, and the amount of ethanol used for the second and subsequent times is the weight of the medicinal material 10 times, filter, combine the filtrates, concentrate the filtrates to a relative density of 1.15-1.30 at 50-70°C, add ethanol to make the alcohol con...

Embodiment 3

[0123] Embodiment 3: the preparation of capsule

[0124] Migao 350g, borneol 7g, chuanxiong 280g, scallion 28g

[0125] The preparation process is:

[0126] (1) Migao is crushed into coarse powder, passed through a 24-mesh sieve, soaked in 5 times the amount of 95% ethanol, soaked for 5 hours, ultrasonically extracted for 90 minutes, filtered with suction, and the filtrate was collected, and the solvent in the filtrate was evaporated by steam , to obtain Migao volatile oil and dregs for subsequent use;

[0127] (2) Ligusticum chuanxiong is crushed into coarse powder, passed through a 24-mesh sieve, soaked in 5 times the amount of 80% ethanol for 3 hours, heated and refluxed 4 times, each extraction time is 2 hours, and the amount of ethanol used for the second and subsequent times is the weight of the medicinal material 5 times, filter, combine the filtrate, concentrate the filtrate to a relative density of 1.10-1.25 under the condition of 50-70°C, add ethanol to make the al...

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Abstract

The invention discloses a preparation method of a medicinal composition for treating the coronary disease and angina pectoris. The preparation method, which aims at disadvantages of present preparation methods of medicinal compositions for treating the coronary disease and angina pectoris allows an ultrasonic wave assisted extraction process to be applied on Cinnamomum migao, and makes the extraction time of Cinnamomum migao be reduced and the yield of Cinnamomum migao be improved. Ligusticum wallichii is heat-refluxed with ethanol, and the obtained extract goes through a macroporous adsorption resin column, so a large mount of impurities of tannins, proteins and the like in Ligusticum wallichii are effectively removed, thereby the purification and the refinement are sufficient, and the extraction is refined. Residue obtained after extracting volatile oil from Cinnamomum migao and residue of Ligusticum wallichii are decocted with water, so large polarity effective components of saccharides and the like are effectively extracted from the two medicines, thereby the medicine effect is increased. The medicinal composition for treating the coronary disease and angina pectoris, which is prepared with the extraction method in the invention, has the advantages of stable extraction technology, simple step, suitableness for the industrialized production, high contents of the effective components, and substantial curative effect. The invention also discloses the medicinal preparation and the preparation method of the medicinal composition for treating the coronary disease and angina pectoris.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a pharmaceutical composition for treating angina pectoris of coronary heart disease, a preparation method and a preparation thereof. Background technique [0002] Coronary heart disease angina pectoris is a common clinical disease caused by acute and transient episodes of myocardial ischemia and hypoxia based on functional changes or organic lesions of the coronary arteries. Symptoms of coronary heart disease are a crushing pain in the center of the chest cavity, which can spread to the neck, jaw, arms, back and stomach. Other possible symptoms of the attack include dizziness, shortness of breath, sweating, chills, nausea and fainting , severe patients may die from heart failure. Angina pectoris is a clinical syndrome mainly manifested by paroxysmal chest pain or chest discomfort, characterized by paroxysmal anterior chest squeezing pain, which ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/8962A61K9/48A61K9/16A61K9/30A61P9/10A61P15/10A61K31/045
Inventor 窦啟玲卫江明周黎亚彭雯
Owner GUIZHOU YIBAI PHARMA CO LTD