Method of wound healing and scar modulation

A wound and scar technology, applied in the field of wound healing and scar modulation, can solve the problems of increased medical expenses, any impact, low response rate, etc., to prevent the wound from contacting the air, avoid resentment, and reduce wound infection.

Inactive Publication Date: 2012-05-30
莫科治疗有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this treatment procedure has the following disadvantages: low response rate, risk of infection, insufficient patient compliance, need to administer the drug in the doctor's office, pain caused by injection, and increased medical costs
Even though topical corticosteroids were found to inhibit certain inflammatory processes such as fibroblast growth, this does not suggest that steroids have any effect on scar healing time

Method used

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  • Method of wound healing and scar modulation
  • Method of wound healing and scar modulation
  • Method of wound healing and scar modulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 - Wound Healing in Hairless Mice

[0055] A) Method of creating a wound

[0056] Before wound formation, 12 hairless mice with an average body weight of 1.62 kg (Skh: HR-1) were given local skin anesthesia for 30 minutes using local anesthesia (LMX-4, Ferndale Laboratories, Inc.). Antiseptics were not used due to their possible local effects on the wound healing process.

[0057] Two linear wounds to a depth of subcutaneous were cut on both sides with a 0.3 mm scalpel blade on the dorsal side of each subject's spine approximately 10 mm on each side. Due to the loose nature of the hairless mouse epidermis, the wound spreads up to 3 mm wide. Each mouse was reared independently.

[0058] B) preparation

[0059] The test formulation contained the following ingredients (by weight): water (79%), ethanol (18%), prednisolone acetate (1%), and ammonium acryloyldimethyltaurate / VP copolymer (2% ).

[0060] C) treatment

[0061] In each test subject, the right wound ...

Embodiment 2

[0077] Example 2 - Wound Healing in Hairless Mice

[0078] A) Method of creating a wound

[0079] Before wound formation, 12 hairless mice with an average body weight of 1.62 kg (Skh: HR-1) were given local skin anesthesia for 30 minutes using local anesthesia (LMX-4, Ferndale Laboratories, Inc.). Antiseptics were not used due to their possible local effects on the wound healing process.

[0080] Mice were subdivided into two groups, A and B. Each mouse was incised with three linear, 10 mm long, parallel spine incision wounds down to the subcutaneous depth. The first incision is close to the spine on the left side (C), one on the same side (L) 10 mm away from the first incision, and one on the right side (R) about 10 mm from the midline or spine. All incisional wounds were excised with a 0.3 mm scalpel blade. Due to the loose nature of the hairless mouse epidermis, the wound spreads up to 3 mm wide. Each mouse was reared independently.

[0081] B) preparation

[0082] T...

Embodiment 3

[0100] Example 3 - Exemplary Corticosteroid Formulations

[0101] The following are exemplary formulations of the invention.

[0102] Formulation 1:

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[0104] Formulation 2:

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[0107] Formulation 3:

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[0109] Formulation 4:

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[0112] Formulation 5:

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[0114] Formulation 6:

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[0116] Formulation 7:

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PUM

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Abstract

The invention relates to methods of promoting wound healing and reducing scar formation by administration of corticosteroids, and pharmaceutical compositions comprising corticosteroids.

Description

[0001] related application [0002] This application claims priority to US Provisional Applications No. 61 / 224,408, filed July 9, 2009, and US Provisional Application No. 61 / 226,216, filed July 16, 2009. Both applications are hereby incorporated by reference in their entirety. technical field [0003] The present invention relates to pharmaceutical compositions containing corticosteroids and methods of using such compositions to promote wound healing and reduce scarring. In particular, the present invention relates to the use for this purpose of corticosteroids formulated with silicone crosslinked polymers. Background technique [0004] After the skin has been injured or cut, the normal physiological healing response results in the formation of a scar. The healing process of skin wounds consists of three phases - the inflammatory phase, the granulation phase and the matrix remodeling phase. In the first phase, an inflammatory response occurs, producing a cascade of bioche...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N45/00A61K31/56
CPCA61K31/573A61K9/0014A61K47/34A61P17/02A61P29/00A61P43/00
Inventor B·C·凯勒
Owner 莫科治疗有限公司
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