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Novel atenolol tablets and preparation method thereof

A tenolol tablet, a new type of technology, applied in the field of medicine, can solve the problems of poor oral absorption and low bioavailability, and achieve the effect of simple operation, good reproducibility, and easy mass production

Inactive Publication Date: 2012-06-27
江苏黄河药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a novel atenolol tablet and its preparation method, to improve poor oral absorption and low bioavailability

Method used

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  • Novel atenolol tablets and preparation method thereof
  • Novel atenolol tablets and preparation method thereof
  • Novel atenolol tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of novel atenolol tablet preparation comprises the component of following percentage by weight:

[0026]

[0027] The production method is as follows:

[0028] (1) Weigh the formula amount of atenolol and poloxamer, mix and pass through an 80-mesh sieve, and heat to melt in an 80°C water bath;

[0029] (2) Cool and solidify the melt obtained in step (1) rapidly at -20°C in an ice-salt bath, take it out after 1 hour, and dry it in a desiccator for 48 hours;

[0030] (3) pulverize the dry matter obtained in step (2) and cross an 80 mesh sieve to obtain atenolol solid dispersion;

[0031] (5) The dispersion obtained in step (3) is mixed with carmellose, cetyl alcohol, magnesium carbonate, and magnesium stearate in the prescribed amount and then directly compressed into tablets to obtain floating tablets retained in the stomach of atenolol .

Embodiment 2

[0033] A kind of novel atenolol tablet preparation comprises the component of following percentage by weight:

[0034]

[0035]

[0036] The production method is as follows:

[0037] (1) Weigh the formula amount of atenolol and poloxamer, mix and pass through an 80-mesh sieve, and heat to melt in an 80°C water bath;

[0038] (2) Cool and solidify the melt obtained in step (1) rapidly at -20°C in an ice-salt bath, take it out after 1 hour, and dry it in a desiccator for 48 hours;

[0039] (3) pulverize the dry matter obtained in step (2) and cross an 80 mesh sieve to obtain atenolol solid dispersion;

[0040] (5) The dispersion obtained in step (3) is mixed with polyvinyl alcohol, stearyl alcohol, magnesium carbonate, and magnesium stearate in the prescribed amount, and then directly compressed into tablets to prepare atenolol gastric retention floating tablets.

Embodiment 3

[0042] A kind of novel atenolol tablet preparation comprises the component of following percentage by weight:

[0043]

[0044] The production method is as follows:

[0045] (1) Weigh the formula amount of atenolol and polyethylene glycol 6000, mix them evenly, pass through an 80-mesh sieve, and heat in a water bath at 80°C until melting;

[0046] (2) Cool and solidify the melt obtained in step (1) rapidly at -20°C in an ice-salt bath, take it out after 1 hour, and dry it in a desiccator for 48 hours;

[0047] (3) pulverize the dry matter obtained in step (2) and cross an 80 mesh sieve to obtain atenolol solid dispersion;

[0048] (5) The dispersion obtained in step (3) is mixed with the formula amount of carmellose, stearyl alcohol, magnesium carbonate, and micropowder silica gel, and then directly compressed into tablets to prepare atenolol gastric retention floating tablets.

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Abstract

The invention discloses novel atenolol tablets, which comprise the following components in percentage by weight: 10 percent of atenolol, 25 to 30 percent of hydrophilic gel material, 20 to 35 percent of framework material, 10 to 25 percent of bleaching aid, 15 to 25 percent of foaming agent and 0.1 to 3 percent of flow aid. The invention also discloses a preparation method for the novel atenolol tablets. According to the novel atenolol tablets, the defect of the atenolol in clinical application is overcome by the technical study of a preparation process for an intragastric floating retention preparation of the atenolol, so that the bioavailability of medicines is improved, the atenolol tablets have an obvious sustained-release function; and therefore, a treatment effect of the atenolol is exerted fully.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a novel atenolol tablet and a preparation method thereof. Background technique [0002] Atenolol (Atenolol, ATN) is a selective beta-beta drug for moderate and mild hypertension caused by various reasons, including elderly hypertension and pregnancy-induced hypertension. 1 Adrenergic blockers. It is a cardioselective β-receptor blocker with no membrane stabilizing effect and no endogenous sympathomimetic activity. Generally used for sinus tachycardia and premature beats, etc., can also be used for hypertension, angina pectoris and glaucoma. [0003] At present, the oral dosage forms of atenolol on the market such as tablets and capsules, the main problems in clinical application are incomplete oral absorption of tablets and low bioavailability, which is only 40-50%. The difference is large, the dosage is difficult to be consistent, and the elderly, bedridden patie...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/165A61P9/12A61P9/06A61P9/10A61P27/06
Inventor 葛海涛唐俊杜云
Owner 江苏黄河药业股份有限公司
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