Quality control method of mangnolia officinalis refined medicinal slice

A quality control method and technology for refining decoction pieces, which are used in measuring devices, instruments, scientific instruments, etc.

Inactive Publication Date: 2012-06-27
重庆天生药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, in the production and circulation of Magnolia officinalis refined decoction pieces, there is no quality control method that can comprehensively ...

Method used

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  • Quality control method of mangnolia officinalis refined medicinal slice
  • Quality control method of mangnolia officinalis refined medicinal slice
  • Quality control method of mangnolia officinalis refined medicinal slice

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Determination of the content of Magnolia officinalis refined decoction pieces by high performance liquid chromatography:

[0038] Chromatographic conditions and system suitability test, octadecylsilane bonded silica gel was used as filler; methanol-water (78:22) was used as mobile phase; detection wavelength was 294nm. The number of theoretical plates should not be less than 3800 based on the magnolol peak.

[0039]Preparation of reference substance solution: Accurately weigh the appropriate amount of magnolol reference substance and honokiol reference substance, and add methanol to prepare solutions containing 40 μg of magnolol and 24 μg of honokiol per 1 ml, respectively.

[0040] For the preparation of the test solution, take 0.2 g of the sample powder (passed through a No. 3 sieve), accurately weigh it, put it in a stoppered conical flask, add precisely 25 ml of methanol and ethanol mixed at 8.5:1, shake well, and Stopper, soak at 36°C for 16 hours, filter, accurat...

Embodiment 2

[0043] Determination of the content of Magnolia officinalis refined decoction pieces by high performance liquid chromatography:

[0044] Chromatographic conditions and system suitability test, octadecylsilane bonded silica gel was used as filler; methanol-water (78:22) was used as mobile phase; detection wavelength was 294nm. The number of theoretical plates should not be less than 3800 based on the magnolol peak.

[0045] Preparation of reference substance solution: Accurately weigh the appropriate amount of magnolol reference substance and honokiol reference substance, and add methanol to prepare solutions containing 40 μg of magnolol and 24 μg of honokiol per 1 ml, respectively.

[0046] For the preparation of the test solution, take 0.2 g of the sample powder (passed through a No. 3 sieve), accurately weigh it, put it in a stoppered Erlenmeyer flask, add precisely 25 ml of a mixture of methanol and ethanol at 8.8:1, shake well, and Stopper, soak at 38°C for 18 hours, filt...

Embodiment 3

[0049] Determination of the content of Magnolia officinalis refined decoction pieces by high performance liquid chromatography:

[0050] Chromatographic conditions and system suitability test, octadecylsilane bonded silica gel was used as filler; methanol-water (78:22) was used as mobile phase; detection wavelength was 294nm. The number of theoretical plates should not be less than 3800 based on the magnolol peak.

[0051] Preparation of reference substance solution: Accurately weigh the appropriate amount of magnolol reference substance and honokiol reference substance, and add methanol to prepare solutions containing 40 μg of magnolol and 24 μg of honokiol per 1 ml, respectively.

[0052] For the preparation of the test solution, take 0.2 g of the sample powder (passed through a No. 3 sieve), accurately weigh it, put it in a stoppered Erlenmeyer flask, add 25 ml of a mixture of methanol and ethanol at a ratio of 9.0:1, shake well, and Stopper, soak at 39°C for 20 hours, fil...

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Abstract

The invention relates to a quality control method of a mangnolia officinalis refined medicinal slice. The quality control method comprises the following steps that: the content of the mangnolia officinalis refined medicinal slice is determined by taking magnolol and a magnolol comparison product as comparisons through a high-performance liquid chromatography; the geoherbalism of contained mangnolia officinalis is determined by taking magnolol and magnolol as reference objects and taking relative retention time and relative retention peak area of a common peak of a high-performance liquid fingerprint through a high-performance liquid fingerprint method; the fact that whether the mangnolia officinalis exists and the content of the mangnolia officinalis can be detected; furthermore, the geoherbalism of the mangnolia officinalis is also further detected; and, due to specificity of traditional Chinese medicines, effects and performances of medicines are directly influenced by the geoherbalism of raw materials, which is recognized in the field; therefore, the quality control method disclosed by the invention is capable of ensuring that the quality of the mangnolia officinalis refined medicinal slice is steadier and more reliable.

Description

technical field [0001] The invention relates to a processing method of Magnolia officinalis refined decoction pieces, especially a quality control method in the processing process. Background technique [0002] The modernization of traditional Chinese medicine is one of the most popular research directions in the development of contemporary Chinese medicine, and has become a hot spot in the domestic and foreign medical circles. However, the uniformity and stability of Chinese medicine—that is, the quality control problem is a bottleneck that restricts the development of Chinese medicine and enters the international market. . [0003] The research and establishment of TCM fingerprints is just a method to solve the key problem of drug quality control and supervision. Although the concept and principle of TCM fingerprints are relatively common, its research has also become one of the hot topics in the field of TCM. However, it is still very difficult to implement it specifica...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/02
Inventor 曾凡明
Owner 重庆天生药业有限公司
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