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Honokiol or magnolol or honokiol-magnolol mixed solid lipid nanosphere preparation and preparation method thereof

A technology of solid lipid nano and honokiol, applied in the field of medicine

Inactive Publication Date: 2011-11-02
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are no publications on solid lipid nanoparticles (SLN) formulations of honokiol, magnolol, and their mixtures

Method used

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  • Honokiol or magnolol or honokiol-magnolol mixed solid lipid nanosphere preparation and preparation method thereof

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[0016] 1) Preparation of the dispersed phase: heat and melt the solid lipid material, then add honokiol, or magnolol, or a mixture of the two, and mix quickly to form a dispersed phase, or add surfactant to the solid lipid material The agent is heated and melted, then add honokiol or magnolol or the mixture of the two, and quickly mix to form a dispersed phase, or after mixing the honokiol or magnolol or the mixture of the two with the surfactant, quickly Mix evenly with the molten lipid material to form a dispersed phase, place the dispersed phase in an environment of -30 ~ 30 ° C, avoid light, cool and solidify for later use, or keep the molten state and directly perform the following operations;

[0017] 2) Preparation of the continuous phase: when no surfactant is added to the dispersed phase, the surfactant is added to the dispersion medium and mixed to form a continuous phase;

[0018] 3) Particle dispersion: Mix the continuous phase (room temperature or raised to the p...

Embodiment 1

[0024] In practice, the present invention is made of: honokiol 35mg, glyceryl monostearate 0.15g, glyceryl behenate 0.25g, soybean lecithin 50mg, poloxamer 188 0.15g, ultrapure water 10ml, Among them, each part is precisely weighed, and honokiol, glyceryl monostearate, glyceryl behenate, soybean lecithin and poloxamer 188 are mixed, heated, melted and mixed, placed in the refrigerator for solidification, and then the above Put the matrix mixture into the insulation sleeve at 76°C, and add 10ml of ultrapure water at the same temperature at the same time, use an ultrasonic cell pulverizer, under the condition of ultrasonic power 400W, use the probe to ultrasonic 16 times, each ultrasonic 6S, interval 6S, and then keep warm (76°C) absorb the dispersion liquid after ultrasound, pass it through a 0.22 μm microporous membrane while it is hot, cool the filtrate at room temperature and fill it with nitrogen to melt seal, and then obtain honokiol solid lipid nanoparticles.

Embodiment 2

[0026] The present invention can also be made by: honokiol 35mg, glyceryl monostearate 0.15g, glyceryl behenate 0.25g, poloxamer 188 0.15g, ultrapure water 10ml to make, wherein, accurate weighing Take each part, mix honokiol, glyceryl monostearate and glyceryl behenate, heat, melt and mix well, add poloxamer 188 dissolved in 80°C ultrapure water, keep warm (80°C) Under normal circumstances, use a high-speed disperser to disperse for 5 minutes at a speed of 11000r / min, then add the initial dispersion to a heat preservation sleeve at 75°C, use an ultrasonic cell pulverizer, and use a probe to sonicate 20 times at an ultrasonic power of 400W, each time Ultrasound for 10S, interval of 10S, and then keep warm (75°C) to absorb the dispersion after ultrasonication, pass it through a 0.22μm microporous membrane while it is hot, cool the filtrate at room temperature and fill it with nitrogen to melt seal to obtain honokiol solid lipid nanoparticles.

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Abstract

The invention relates to a honokiol or magnolol or honokiol-magnolol mixed solid lipid nanosphere preparation and a preparation method thereof. According to the invention, the production problem of the honokiol or magnolol or honokiol-magnolol mixed solid lipid nanosphere preparation can be effectively solved. The raw materials of the honokiol or magnolol or honokiol-magnolol mixed solid lipid nanosphere preparation comprise 0.001-40 wt% of honokiol or magnolol or the honokiol-magnolol mixture, 0.05-99.9 wt% of the solid lipid material, 0.001-85 wt% of a surfactant, and the balance being disperse medium, wherein the sum of the weight of honokiol or magnolol or the honokiol-magnolol mixture, the solid lipid material and the surfactant accounts for 0.01-60% of the total weight of the lipid nanosphere preparation. The preparation method provided by the invention comprises the following steps of: preparing a dispersed phase, preparing a continuous phase, mixing the dispersed phase and the continuous phase, dispersing the mixture to a nanometer preparation, filtering and sterilizing. The honokiol or magnolol or honokiol-magnolol mixed solid lipid nanosphere preparation has advantages of scientific composition, simple preparation and good stability, can be prepared in the forms of an injection and an ophthalmic preparation, or processed in the forms of a solid preparation, a semisolid preparation and a gas preparation.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a solid lipid nanoparticle preparation of honokiol or magnolol or a mixture of the two and a preparation method thereof. Background technique [0002] Honokiol (honokiol) and magnolol (magnolol) are active ingredients isolated from Magnolia officinalis Magnolia, belonging to biphenol compounds (Liu Keyun, Dong Zhi, Zhu Yi. Honokiol and honokiol Pharmacological research status of Chinese patent medicine, 2006 (28) 5: 716). In 1930, Sugii in Japan first isolated magnolol from the bark of Magnolia officinalis in my country, and in 1973, Fujita isolated magnolol and its isomer honokiol from Magnolia officinalis and Magnolia officinalis in Japan (Wang Liqing, Jiang Ronggao , Chen Huifang. Research progress on the pharmacological effects of magnolol and honokiol, Chinese herbal medicine, 2005, 36 (10): 1591). Experiments have proved that honokiol and magnolol have a wide range of pharmacologic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61K9/16A61P25/22A61P31/00A61P29/00A61P35/00A61P21/02A61P7/02A61P3/06A61P39/00
Inventor 王艳芝郑甲信王海玲汤玉杰
Owner ZHENGZHOU UNIV
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