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Method for separating and purifying magnolol and honokiol by HP-20 macroporous resin

A technology of HP-20 and honokiol, applied in the field of green chemical process, can solve the problems of insufficient product quality and market competitiveness, low purity and yield, and insignificant efficacy, and achieves operational and product safety, environmental protection, etc. Friendly, theoretically novel effect

Inactive Publication Date: 2010-06-16
HUNAN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously above-mentioned relevant magnolol and honokiol extraction, separation and purification method can prepare magnolol and honokiol extract with certain purity and yield, but due to being limited by technical means and using A large number of toxic organic solvents or chemical preparations make the product obviously have defects such as poor safety or low purity and yield, easy moisture absorption, ineffective efficacy, insufficient product quality and market competitiveness, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The HP-20 macroporous adsorption resin that has been cleaned is selected as the separation and purification resin of magnolol and honokiol, and 400 grams of above-mentioned magnolol crude extracts are dissolved in 300 milliliters of edible ethanol with a volume concentration of 60%. Magnolia officinalis crude extraction solution, put the solution on the column, after HP-20 macroporous resin is saturated and stabilized, first use 3BV water to wash away polar impurities and a small part of pigment at a flow rate of 2BV / hour, and then use 3BV volume concentration 65% (the concentration of all ethanol below is the volume concentration) edible ethanol washes away most of the impurities such as pigments at a flow rate of 2BV / hour, and finally uses 3BV of 78% edible ethanol at a flow rate of 2BV / hour and 3BV 87% edible ethanol is eluted sequentially at a flow rate of 2BV / hour, and collected in parts: ① Collect the 2.0-3.0BV part eluted with 78% edible ethanol, and concentrate a...

example 2

[0023]The HP-20 macroporous adsorption resin that has been cleaned is selected as the separation and purification resin of magnolol and honokiol, and 400 grams of above-mentioned magnolol crude extracts are dissolved in 300 milliliters of edible ethanol with a volume concentration of 60%. Magnolia officinalis crude extraction solution, put the solution on the column, after HP-20 macroporous resin is adsorbed and saturated and stabilized, first use 3BV of water to wash away polar impurities and a small part of pigment at a flow rate of 2BV / hour, and then use 3BV of 65% Edible ethanol washes away most of the pigment and other impurities at a flow rate of 2BV / hour, and finally uses 3BV of 76% edible ethanol at a flow rate of 2BV / hour and 3BV of 85% edible ethanol at a flow rate of 2BV / hour for elution in sequence , collected by parts: ① Collect the 2.0-3.0 BV part eluted with 76% edible ethanol, and under the conditions of -0.09MPa and 42°C, concentrate under reduced pressure to r...

example 3

[0025] The HP-20 macroporous adsorption resin that has been cleaned is selected as the separation and purification resin of magnolol and honokiol, and 400 grams of above-mentioned magnolol crude extracts are dissolved in 300 milliliters of edible ethanol with a volume concentration of 60%. Magnolia officinalis crude extraction solution, put the solution on the column, after HP-20 macroporous resin is adsorbed and saturated and stabilized, first use 3BV of water to wash away polar impurities and a small part of pigment at a flow rate of 2BV / hour, and then use 3BV of 65% Edible ethanol washes away most of the pigment and other impurities at a flow rate of 2BV / hour, and finally uses 3BV of 80% edible ethanol at a flow rate of 2BV / hour and 3BV of 89% edible ethanol at a flow rate of 2BV / hour. , collected by parts: ① Collect the 2.0-3.0 BV part eluted with 80% edible ethanol, and under the conditions of -0.05MPa and 70°C, concentrate under reduced pressure to recover ethanol, vacuum...

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Abstract

The invention provides a method for separating and purifying magnolol and honokiol by HP-20 macroporous resin. The method comprises a step of extracting coarse extracts of magnolia bark by 50 to 70 volume percent edible ethanol at the temperature of between 80 and 90 DEG C; and the method also comprises a step of separating and purifying the coarse extracts of magnolia bark by the HP-20 macroporous adsorptive resin, in which the coarse extracts of magnolia bark is dissolved in the edible ethanol, the HP-20 macroporous adsorptive resin is used for adsorption until saturated, the coarse extracts of magnolia bark are eluted by water, low-concentration edible ethanol and high-concentration edible ethanol respectively, the eluent is collected in order, the collected eluent is condensed by decompression to recover the ethanol, and then freeze-dried under a vacuum condition to obtain the purified magnolol and honokiol. By adopting the method, the magnolol and honokiol can be safely and effectively separated and purified by industrialized production.

Description

Technical field: [0001] The present invention relates to a green chemical process technology for separating and purifying Chinese medicinal active ingredients of Chinese herbal medicine plants, especially a green separation of magnolol and honokiol in magnolia bark plants by using HP-20 macroporous adsorption resin Purification method. Background technique: [0002] Magnolia officinalis is the dried bark, branch bark and root bark of Magnolia officinalis Rehd.et Wils. It is a commonly used traditional Chinese medicinal material unique to our country. It is known as the three medicinal materials and is one of the four important Chinese medicinal materials of musk, licorice, Eucommia and Magnolia officinalis planned and managed by the state. There are a large number of distributions in Yunnan, Sichuan, Guizhou, Yunnan, Zhejiang, Fujian, Hunan and other provinces in my country. There are dozens of Chinese patent medicine formulas using Magnolia officinalis as a raw material, ...

Claims

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Application Information

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IPC IPC(8): C07C39/21C07C37/82A61K36/575
Inventor 肖文军傅冬和李园莉
Owner HUNAN AGRICULTURAL UNIV
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