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Levoamlodipine, aliskiren and hydrochlorothiazide compound antihypertensive medicine

A technology of levamlodipine and hydrochlorothiazide, which is applied in the field of compound antihypertensive drugs of alicoren and hydrochlorothiazide, levamlodipine, can solve the problems that the mechanism of action is not fully understood, achieve excellent blood pressure lowering effect, reduce side effects, and good The effect of antihypertensive effect

Inactive Publication Date: 2012-07-11
邬林祥 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its mechanism of action is not fully understood

Method used

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  • Levoamlodipine, aliskiren and hydrochlorothiazide compound antihypertensive medicine
  • Levoamlodipine, aliskiren and hydrochlorothiazide compound antihypertensive medicine
  • Levoamlodipine, aliskiren and hydrochlorothiazide compound antihypertensive medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Preparation of Aliskiren, Levoamlodipine and Hydrochlorothiazide Fixed Prescription Tablets

[0017]

[0018]

[0019] The preparation method is

[0020] 1. Pass Aliskiren, levamlodipine, and hydrochlorothiazide (hereinafter referred to as main ingredients) respectively through a 100-mesh sieve and mix them uniformly in a mixer.

[0021] 2. Put the starch, powdered sugar and dextrin through a 100-mesh sieve and put them into the mixer once to mix evenly, then add the mixed main ingredients and mix evenly, and add an appropriate amount of 70% ethanol to make a soft material.

[0022] 3. Granulate through a 20-mesh sieve.

[0023] 4. Dry the granules in a fluidized bed.

[0024] 5. The dried granules are sized through a 18-mesh sieve.

[0025] 6. Put the whole granules into the mixer, put in magnesium stearate and mix well.

[0026] 7. Tablet into 1,000,000 pieces.

Embodiment 2

[0028] Preparation of Aliskiren, Levoamlodipine and Hydrochlorothiazide Fixed Capsules

[0029]

[0030] The preparation method is

[0031] 1. Aliskiren, levamlodipine, and hydrochlorothiazide (hereinafter referred to as main ingredients) are mixed uniformly and passed through a 100-mesh sieve.

[0032] 2. Put the starch, powdered sugar and dextrin through a 100-mesh sieve and put them into the mixer once to mix evenly, then add the mixed main ingredients and mix evenly, and add an appropriate amount of 70% alcohol to make a soft material.

[0033] 3. Granulate through a 20-mesh sieve.

[0034] 4. Dry the granules in a fluidized bed.

[0035] 5. The dried granules are sized through a 18-mesh sieve.

[0036] 6. Put the prepared granules in a capsule filling machine to prepare capsules.

[0037] 7. Make 1,000,000 pieces.

Embodiment 3

[0039] Preparation of Aliskiren, Levoamlodipine and Hydrochlorothiazide Fixed Prescription Powder

[0040] Alikron 1.25kg

[0041] Levoamlodipine 0.0375kg

[0042] Hydrochlorothiazide 0.375kg

[0043] The preparation method is

[0044] 1. Pass Aliskiren, levamlodipine, and hydrochlorothiazide (hereinafter referred to as main ingredients) respectively through a 100-mesh sieve and mix them uniformly in a mixer.

[0045] 2. Make 1,000,000 packs after dividing doses.

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Abstract

The invention relates to a levoamlodipine, aliskiren and hydrochlorothiazide compound antihypertensive medicine. A weight ratio of aliskiren to levoamlodipine to hydrochlorothiazide, or A weight ratio of the salt of aliskiren to the salt of levoamlodipine to the salt of hydrochlorothiazide is (500-5):1:(50-0.25), (120-15):1:(10-0.65) preferably and 30:1:10 optimally. The medicinal composition has an excellent antihypertensive effect, and the toxic and side effects are obviously reduced.

Description

technical field [0001] The invention relates to the technical field of antihypertensive drugs, in particular to compound antihypertensive drugs of levamlodipine, alikolam and hydrochlorothiazide. Background technique [0002] Hypertension is a clinical syndrome mainly manifested by increased systemic arterial pressure. It is the most common cardiovascular disease. Long-term high blood pressure can affect the functions of the heart, brain, kidneys and other organs, eventually leading to the decline of these organ functions. In view of the dangers of high blood pressure, how to find and discover safe and effective new antihypertensive drugs has become an important task for pharmaceutical workers. At present, there are many kinds of antihypertensive drugs, which are divided into diuretics and adrenergic receptor blockers according to the mechanism of action. Drugs, calcium channel blockers (CCB), angiotensin-converting enzyme inhibitors (ACEI), angiotensin II receptor antagonis...

Claims

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Application Information

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IPC IPC(8): A61K31/549A61P9/12A61K31/4422A61K31/165
Inventor 邬林祥邬林云
Owner 邬林祥