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Iodine glycerol nipple infusion and preparation method thereof

A technology of iodine glycerin and nipples, which is applied in the direction of pharmaceutical formulas, local antibacterial agents, active ingredients of iodine compounds, etc., can solve problems such as inability to effectively prevent chapped nipple skin and frostbite, inability to effectively prevent frostbite, and short duration of action, etc., to achieve improved Overall milk yield and milk quality, prolonged killing and inhibition time, delayed volatilization effects

Active Publication Date: 2012-07-11
NEIMENGU RUIPUDADI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantages are strong bactericidal power and low irritation, but because the above-mentioned medicated bath liquids are all water-soluble, they evaporate quickly after the medicated bath, the duration of action is short, and it is easy to cause repeated infection of the breast
And in the cold and dry winter, it cannot effectively prevent chapped nipple skin and frostbite
[0003] At present, most of the nipple dipping liquids commonly used abroad are products of iodine glycerin, which are characterized by strong bactericidal power, low irritation, and moisturizing and skin care effects on the nipples. However, ethanol with antifreeze effect is not added to the formula , sodium chloride, cannot effectively prevent frostbite of cows after dipping in the cold season

Method used

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  • Iodine glycerol nipple infusion and preparation method thereof
  • Iodine glycerol nipple infusion and preparation method thereof
  • Iodine glycerol nipple infusion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Party:

[0023]

[0024] Preparation:

[0025] A, take iodine and potassium iodide accurately by prescription quantity, potassium iodide is dissolved in 100ml water earlier, wait to add iodine while stirring completely after dissolving completely, make it dissolve completely, be solution A;

[0026] B. Take about 50ml of purified water, add the prescribed amount of sodium chloride, stir to dissolve, and it is solution B;

[0027] C. Under stirring state, mix solution A and solution B, and stir evenly;

[0028] D, add the ethanol of prescription quantity in the above-mentioned solution, after stirring to mix evenly, add the glycerin of prescription quantity, stir to mix evenly;

[0029] E. Dilute the above solution to 1000ml with purified water and stir evenly.

Embodiment 2

[0031] Party:

[0032]

[0033] Preparation:

[0034] A, take iodine and potassium iodide accurately by prescription quantity, potassium iodide is dissolved in 100ml water earlier, wait to add iodine while stirring completely after dissolving completely, make it dissolve completely, be solution A;

[0035] B. Take about 100ml of purified water, add the prescribed amount of sodium chloride, stir to dissolve, and become solution B;

[0036] C. Under stirring state, mix solution A and solution B, and stir evenly;

[0037] D, add the ethanol of prescription quantity in the above-mentioned solution, after stirring to mix evenly, add the glycerin of prescription quantity, stir to mix evenly;

[0038] E. Dilute the above solution to 1000ml with purified water and stir evenly.

Embodiment 3

[0039] Example Triiodoglycerin nipple infusion local allergy and local irritation test report

[0040] 1. Materials

[0041] 1. The iodine glycerin nipple infusion prepared in Example 2 of the present invention.

[0042] 2. Laboratory equipment

[0043] 3. Experimental animals: white rabbits, weighing 2-3kg; healthy white guinea pigs, male and female, weighing 200g-300g.

[0044] 2. Method

[0045] 1. Multiple complete skin irritation tests

[0046] (1) Select 10 healthy rabbits with a body weight of 2-3 kg. 24 hours before the test, cut off the hair on both sides of the rabbit's back and spine without damaging the skin.

[0047] (2) The next day, drop 0.5ml of the original solution of the test substance directly on one side of the intact skin with an area of ​​3cm×3cm, and apply two layers of gauze of the same size on the surface of the depilated skin on one side, and then apply a layer of Cover with non-irritating plastic film and fix with non-irritating adhesive tape. ...

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Abstract

The invention discloses iodine glycerol nipple infusion and a preparation method thereof. The iodine glycerol nipple infusion provided by invention belongs to local body surface disinfectant, which is composed of iodine, potassium iodide, glycerol, ethanol, sodium chloride and the like. The iodine glycerol nipple infusion prepared by the invention is specifically used for the medicated bath disinfecting of cow nipple skin, and is characterized by wide sterilization spectrum, low effective concentration, quick action speed, steady property, no stimulation, no residual, no harm on people and livestock and being used under a cold and dry weather.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a local body surface disinfectant specially used for milk cow teats. Background technique [0002] Nipple medicated bath is of great significance in preventing the occurrence of mastitis in dairy cows. For the method of medicated bath, you can use a medicated bath cup to soak each nipple individually, or you can use a hand-held sprayer or a hose connected to the internal pressure pump of the disinfection pool to spray and sterilize the nipples. Commonly used nipple dipping liquids in China include povidone-iodine, chlorhexidine, sodium hypochlorite, and bromogeramine. The advantages are strong bactericidal power and low irritation, but because the above-mentioned medicated bath liquids are all water-soluble, they evaporate quickly after the medicated bath, the duration of action is short, and it is easy to cause repeated infection of the breast. Moreover, in the cold...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61K47/10A61P15/04A61P31/02
Inventor 程孝新郝永清
Owner NEIMENGU RUIPUDADI BIO TECH
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