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Iodine glycerol nipple infusion and preparation method thereof

A technology of iodine glycerin and nipples, which is applied in the direction of local antibacterial agents, active ingredients of iodine compounds, diseases, etc., can solve the problems of not being able to effectively prevent chapped nipple skin and frostbite, being unable to effectively prevent frostbite, and short duration of action, etc., to achieve improvement Overall milk yield and milk quality, prolonged killing and inhibition time, delayed volatilization effects

Active Publication Date: 2013-07-31
NEIMENGU RUIPUDADI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantages are strong bactericidal power and low irritation, but because the above-mentioned medicated bath liquids are all water-soluble, they evaporate quickly after the medicated bath, the duration of action is short, and it is easy to cause repeated infection of the breast
And in the cold and dry winter, it cannot effectively prevent chapped nipple skin and frostbite
[0003] At present, most of the nipple dipping liquids commonly used abroad are products of iodine glycerin, which are characterized by strong bactericidal power, low irritation, and moisturizing and skin care effects on the nipples. However, ethanol with antifreeze effect is not added to the formula , sodium chloride, cannot effectively prevent frostbite of cows after dipping in the cold season

Method used

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  • Iodine glycerol nipple infusion and preparation method thereof
  • Iodine glycerol nipple infusion and preparation method thereof
  • Iodine glycerol nipple infusion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Party:

[0023]

[0024] Preparation:

[0025] A. Accurately weigh the iodine and potassium iodide according to the prescribed amount, first dissolve the potassium iodide in 100ml of water, add iodine while stirring after it is completely dissolved, to make it completely dissolved, which is solution A;

[0026] B. Take about 50ml of purified water, add the prescribed amount of sodium chloride, stir to dissolve, and become solution B;

[0027] C. Under stirring, mix solution A and solution B and stir evenly;

[0028] D. Add the prescription amount of ethanol to the above solution, stir to make the mixture uniform, add the prescription amount of glycerin, stir to mix evenly;

[0029] E. Dilute the above solution to 1000ml with purified water and stir evenly to obtain.

Embodiment 2

[0031] Party:

[0032]

[0033] Preparation:

[0034] A. Accurately weigh the iodine and potassium iodide according to the prescribed amount, first dissolve the potassium iodide in 100ml of water, add iodine while stirring after it is completely dissolved, to make it completely dissolved, which is solution A;

[0035] B. Take about 100ml of purified water, add the prescribed amount of sodium chloride, stir to dissolve, and get solution B;

[0036] C. Under stirring, mix solution A and solution B and stir evenly;

[0037] D. Add the prescription amount of ethanol to the above solution, stir to make the mixture uniform, add the prescription amount of glycerin, stir to mix evenly;

[0038] E. Dilute the above solution to 1000ml with purified water and stir evenly to obtain.

Embodiment 3

[0039] Example Test report of local allergy and local irritation of triiodoglycerin nipple infusion

[0040] 1. Material

[0041] 1. The iodine glycerin nipple infusion prepared in Example 2 of the present invention.

[0042] 2. Routine laboratory equipment

[0043] 3. Test animals: white rabbits, weighing 2-3kg; healthy white guinea pigs, half male and half, weighing 200g~300g.

[0044] Two, method

[0045] 1. Multiple complete skin irritation tests

[0046] (1) Choose 10 healthy rabbits weighing 2~3kg, and cut off the hair on both sides of the rabbit's back spine 24h before the test, without damaging the skin, and the hair removal range is about 3cm×3cm on the left and right.

[0047] (2) The next day, drop 0.5ml of the original solution of the test substance directly on the whole skin with an area of ​​3cm×3cm, and apply 2 layers of gauze of the same size on the surface of the skin with no hair, and then apply a layer Cover with non-irritating plastic film and fix it with non-irritatin...

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Abstract

The invention discloses iodine glycerol nipple infusion and a preparation method thereof. The iodine glycerol nipple infusion provided by invention belongs to local body surface disinfectant, which is composed of iodine, potassium iodide, glycerol, ethanol, sodium chloride and the like. The iodine glycerol nipple infusion prepared by the invention is specifically used for the medicated bath disinfecting of cow nipple skin, and is characterized by wide sterilization spectrum, low effective concentration, quick action speed, steady property, no stimulation, no residual, no harm on people and livestock and being used under a cold and dry weather.

Description

Technical field [0001] The invention belongs to the field of veterinary medicine preparations, and particularly relates to a local body surface disinfectant specially used for milk cow teats. Background technique [0002] The nipple bath is of great significance in preventing the occurrence of cow mastitis. In the medicated bath, you can use the medicated bath cup to infiltrate each nipple individually, or use a hand-held sprayer or a hose connected to the pressure pump in the disinfection tank to spray and sterilize the nipple. The commonly used nipple baths in China include povidone-iodine, chlorhexidine, sodium hypochlorite, and promethazine. The advantages are strong bactericidal power and low irritation. However, since the above medicated bath liquids are all water-soluble, they evaporate quickly after bathing, have a short duration of action, and are likely to cause repeated breast infections. And in the cold and dry winter, it cannot effectively prevent the nipple skin f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/18A61K47/10A61P15/04A61P31/02
Inventor 程孝新郝永清
Owner NEIMENGU RUIPUDADI BIO TECH
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