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Cyclocarya paliurus capsule and preparation method thereof

The technology of green pennywort and capsule is applied in food preparation, capsule delivery, pharmaceutical formulation and other directions, which can solve the problems of simple form, low content of active ingredients in the product, single development and preparation method of pennywort, and achieves good fluidity, Guaranteed effect of stability

Active Publication Date: 2012-07-11
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Technical problem to be solved: the present invention can prepare soft capsules and hard capsules containing triterpenoids and polysaccharides as the active ingredients of Cyclocarya paliurus, which solves the problem of single development and preparation methods of Cyclocarya paliurus, low active ingredient content and simple form. problem, which can better guarantee its curative effect and the stability of its active ingredients

Method used

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  • Cyclocarya paliurus capsule and preparation method thereof
  • Cyclocarya paliurus capsule and preparation method thereof
  • Cyclocarya paliurus capsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Dry and pulverize the leaves of Cyclocarya paliurus, pass through a 40-mesh sieve, and carry out ultrasonic and microwave synergistic extraction at 60°C for 2 hours with a mass ratio of material and water of 1:8. During extraction, the ultrasonic power is 400w, the frequency is 25KHz, the microwave power is 600w, and the frequency is 2450MHz, the extract is concentrated under reduced pressure to a relative density of 1.15 (room temperature), the concentrate is precipitated by adding 3 times the volume of absolute ethanol, and the precipitate is dissolved in hot water and spray-dried to obtain the total polysaccharide powder of Cyclocarya paliurus; Qian Liu powder, with the solid-liquid mass ratio of 1: 20, with the ethanol of 60% vt as extractant, carry out ultrasonic-assisted extraction at 60 ℃, ultrasonic power is 600w, frequency 25KHz, and extracting solution is reclaimed to ethanol content lower than through decompression 5%wt, adding an appropriate amount of water t...

Embodiment 2

[0030]Dry and pulverize the leaves of Cyclocarya paliurus, pass through a 30-mesh sieve, and conduct ultrasonic and microwave synergistic extraction at 70°C for 1.5 hours at a material-to-water mass ratio of 1:10. During extraction, the ultrasonic power is 600w, the frequency is 25KHz, and the microwave power is 700w. The frequency is 2450MHz, the extract is concentrated under reduced pressure to a relative density of 1.2 (room temperature), the concentrate is precipitated by adding 3 times the volume of absolute ethanol, and the precipitate is dissolved in hot water and spray-dried to obtain the total polysaccharide powder of Cyclocarya paliurus; Cyclocarya paliurus powder, with the mass ratio of solid to liquid 1:15, 70% vt ethanol is used as the extractant to carry out ultrasonic-assisted extraction at 55°C, the ultrasonic power is 700w, the frequency is 25KHz, and the extract is recovered under reduced pressure until the ethanol content is low Adding an appropriate amount o...

Embodiment 3

[0033] Dry and pulverize the leaves of Cyclocarya paliurus, pass through a 30-mesh sieve, and carry out ultrasonic and microwave synergistic extraction at 80°C for 1.5 hours at a mass ratio of material to water of 1:15. During extraction, the ultrasonic power is 800w, the frequency is 25KHz, and the microwave power is 600w. The frequency is 2450MHz, the extract is concentrated under reduced pressure to a relative density of 1.18 (room temperature), the concentrate is precipitated by adding 3 times the volume of absolute ethanol, and the precipitate is dissolved in hot water and spray-dried to obtain Cyclocarya paliurus total polysaccharide powder; Cyclocarya paliurus powder, with the mass ratio of solid to liquid of 1:10, 80% vt ethanol is used as the extractant to carry out ultrasonic-assisted extraction at 50°C, the ultrasonic power is 800w, the frequency is 25KHz, and the extract is recovered under reduced pressure until the ethanol content is low Adding an appropriate amoun...

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Abstract

The invention provides a cyclocarya paliurus capsule and a preparation method thereof. A capsule core comprises cyclocarya paliurus total polysaccharides and cyclocarya paliurus total triterpenoids, wherein the cyclocarya paliurus total polysaccharides account for 5%-60%, and the cyclocarya paliurus total triterpenoids account for 5%-60% according to mass ratio. A property index contrast table ofa soft capsulate core proves that a capsulate core liquid obtained after optimization of formula screening and manufacture process has good fluidity and is stable without layering, and the difficulties during the preparation of a cyclocarya paliurus soft capsule are solved. A property index change table of a hard capsulate core proves that hard capsulate core particles obtained after optimizationof the formula screening and the manufacture process has good fluidity and is low in moisture absorption, and the difficulties during the preparation of a cyclocarya paliurus hard capsule are solved.Animal experiments prove that the cyclocarya paliurus capsule can remarkably reduce blood sugar of a tested diabetes small mouse.

Description

technical field [0001] The invention belongs to the technical field of deep processing of Cyclocarya paliurus, specifically relates to soft capsules and hard capsules of Cyclocarya paliurus and a preparation method thereof, in particular to a capsule of Cyclocarya paliurus made from active polysaccharides and triterpenoids in leaves of Cyclocarya paliurus and its preparation method. Background technique [0002] Cyclocarya paliurus (Batal) Ijinskaja [Cyclocarya paliurus (Batal) Ijinskaja] is also known as green money plum, mountain hemp willow, sweet tea tree, and a string of money. Department of dicotyledonous Juglandaceae Cyclocarya genus, is a unique single species of plants in my country. Because the shape of the tree is like a willow, the fruit is round like a copper coin, and the color is green and drooping, so it is called "Qingqian Liu". It is widely distributed in Jiangxi, Zhejiang, Jiangsu, Anhui, Fujian, Taiwan, Hubei, Sichuan, Guizhou, Yunnan and other places. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61K9/48A23L1/29A61P3/10A23L33/00
Inventor 李婷婷吴彩娥方升佐范龚建洑香香
Owner NANJING FORESTRY UNIV
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