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Medicine composition for preventing or curing gout

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc.

Active Publication Date: 2012-07-11
IND TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have a known risk of serious side effects and drug-drug interactions, especially in the elderly population and in patients receiving concomitant treatment for gout and chronic kidney disease (CKD) or diabetes

Method used

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  • Medicine composition for preventing or curing gout
  • Medicine composition for preventing or curing gout
  • Medicine composition for preventing or curing gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] [Embodiment 1] Extraction and purification of Dinosaurs

[0053] Grind the dried whole plant of Hinosaurus into powder 2Kg, add 95% ethanol, heat and reflux for 3 hours, and concentrate the alcohol extract under reduced pressure to obtain 200 g of Hindus ethanol extract.

[0054] Get 200g of the above-mentioned Cerulean ethanol extract, add it to a silica gel-filled chromatographic column (10×15cm), and pass through the eluent n-hexane / ethyl acetate=10 / 1, 5 / 1, 3 / 1, 1 / 1 and n-Hexane / ethyl acetate / methanol=6 / 4 / 1, 3 / 2 / 1 and 1200ml of methanol for each 1200ml gradient elution primary separation to obtain 140g of primary separation liquid. Then 140 g of the primary separation liquid was subjected to silica gel packed column chromatography (10×15 cm) for separation, and separated by gradient elution of 1000 ml of dichloromethane, dichloromethane / methanol=10 / 1, 5 / 1, 7 / 3 and methanol , to obtain two fractions that are enriched and separated. The two fractions separated by enr...

Embodiment 2

[0055] [Example 2] Cell Viability Evaluation of Spurgrass Extract

[0056] Effects of ethanol extract of hinosaurus, hinogenolide and parsnip oxalic acid on THP-1 cells of human monocytes Inhibitory effect of IL-β secretion by

[0057] THP-1 cells (CCRC 68023) were implanted into 96-well plates, and the number of implanted cells was 1.5×10 5 cells / well, add phorbol 12-myristate 13-acetate (Phorbol12-Myristate 13-acetate; PMA) (Sigma, Cat.No.P-8139) to the cell culture medium to make PMA final The concentration is 5ng / ml. The 96-well plate was cultured overnight in a 37°C incubator. Take out the cell culture medium containing PMA the next day, and add fresh cell culture medium (RPMI-1640, Invitrogen, Cat.No.31800-022) containing 2% serum, and then add different concentrations of the obtained Hindu in Example 1 The ethanol extract, porphyrin or parsnip oxalic acid were reacted in the 96-well plate at 37° C. for 60 minutes. After the reaction, monosodium urate (MSU) (Sigm...

Embodiment 3

[0066] [Example 3] Evaluation of the activity of hspur extract in animal models

[0067] Monosodium Urate (MSU) Induced Mouse Model of Celiac Disease

[0068] For the animal model of MSU-induced peritoneal inflammation in mice, refer to Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout. Arthritis Rheum. 2009Jan; 60(1): 281-9. The experimental method was carried out. This document is incorporated by reference into this application in its entirety.

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Abstract

The present invention provides a medicine composition for preventing or curing gout, comprising Anisomeles indica abstract as an active component, wherein the Anisomeles indica abstract comprising Anisomeles indica lactone, Radices Sileris oxalic acid or the composition thereof.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing or treating gout, in particular to a pharmaceutical composition for preventing or treating gout which uses an extract of Anisomeles indica as an active ingredient. Background technique [0002] Gout is one of the common metabolic diseases, characterized by the deposition of uric acid crystals in the toes, ankles, knees, wrists, fingers, elbows and other joints, causing arthritis there. The diagnosis of gout is defined as the concentration of urate in the blood exceeds 6.8 mg / dl, which is called hyperuricemia. If the concentration of urate in the blood exceeds the aforementioned threshold for renal metabolism, excess urate will form crystals, or called tophi, and accumulate in the joints. Tophi accumulated in the joints can cause acute arthritis and inflammation around the joints, including the activation of complement and the release of inflammatory cytokines. For example, purines, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K31/365A61P19/06
Inventor 李连滋罗吉孟石英珠梁惠如李承榆许振霖林晓珮刘万煌林佩欣黄国魁蔡莹霏许怡玲
Owner IND TECH RES INST
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