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Temperature control magnetic bone cement and preparation method thereof

A bone cement and magnetic technology, which is applied in the field of temperature-controlled magnetic bone cement and its preparation, can solve the problem of easy overheating of magnetic bone cement and achieve good cell compatibility

Inactive Publication Date: 2012-07-11
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem that the existing magnetic bone cement is easily overheated, the present invention provides a temperature-controlled magnetic bone cement and a preparation method thereof. The bone cement has good cell compatibility, and its Curie temperature is about 50°C. When the temperature reaches When the temperature is 50°C, the material stops heating, and when the temperature is lower than this temperature, it can be reheated to ensure a suitable temperature, and at the same time prevent overheating during the thermotherapy process and improve the safety of magnetic hyperthermia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A temperature-controlled magnetic bone cement, the preparation steps of which are as follows:

[0028] 1) Preparation of manganese zinc ferrite

[0029] 1) Weigh FeCl separately 3 ·6H 2 O, ZnCl 2 and MnCl 2 4H 2 O and press Mn 0.15 Zn 0.85 Fe 2 o 4 The stoichiometric ratio of ingredients, adding ultra-pure water, made a solution with a metal ion concentration of 0.3mol / L, and reacted at a constant temperature of 90°C for 4 hours;

[0030] During the reaction, the NaOH solution with a concentration of 1mol / L was added dropwise to the solution at a stirring speed of 3000rpm to control the pH value of the reaction solution to be 10;

[0031] 2) Wash the precipitate produced after the reaction in step 1 with ultrapure water and centrifuge at 6000rpm, and dry the separated precipitate at a temperature of 60°C and a pressure of 0.09-0.093MPa to obtain manganese-zinc ferrite Precursor, spare;

[0032] 3) Calcining the obtained manganese zinc ferrite precursor at a t...

Embodiment 2

[0057] The preparation of manganese zinc ferrite and bone cement matrix are as shown in Example 1.

[0058] Take manganese zinc ferrite powder and add it to the bone cement solid phase matrix and mix evenly to prepare a bone cement mixture; then add the bone cement liquid phase matrix into the bone cement mixture according to the weight ratio of 1:1, and then Use a stainless steel knife to blend for 3 minutes to obtain the product;

[0059] Wherein, the addition amount of manganese zinc ferrite powder is 40% of the total weight of the final product.

[0060] The performance of the temperature-controlled magnetic bone cement obtained was detected by the experimental method in Example 1, and the results were as follows: the curing time was measured to be 10 ± 1 min, and the mechanical compressive strength was 91.1 ± 3.7 Mpa; the vibrating sample magnetometer was used to measure Get material in 1.59×10 6 A·m -1 The saturation magnetization is 1.97A m 2 kg -1 ; At a base tem...

Embodiment 3

[0062] The preparation of manganese zinc ferrite and bone cement matrix are as shown in Example 1.

[0063] Take manganese zinc ferrite powder and add it to the bone cement solid phase matrix and mix evenly to prepare a bone cement mixture; then add the bone cement liquid phase matrix into the bone cement mixture according to the weight ratio of 1:1, and then Use a stainless steel knife to blend for 3 minutes to obtain the product;

[0064] Wherein, the addition amount of manganese zinc ferrite powder is 60% of the total weight of the final product.

[0065] The performance of the temperature-controlled magnetic bone cement obtained was detected by the experimental method in Example 1, and the results were as follows: the solidification time was 25 ± 2.5min, and the compressive strength was 83.6 ± 4.2Mpa; Get material in 1.59×10 6 A·m -1 The saturation magnetization is 3.15A m 2 kg -1 ; At a base temperature of 37°C, heating can be achieved under an alternating magnetic ...

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Abstract

The invention relates to temperature control magnetic bone cement and a preparation method thereof. The preparation method comprises the following steps: weighing FeCl3 6H2O, ZnCl2 and MnCl2 4H2O, mixing the materials according to the stoichiometric ratio of Mn0.15Zn0.85Fe2O4, adding ultra-pure water for preparing a solution, reacting, then getting a precursor of a manganese-zinc ferrite, calcining the precursor of the manganese-zinc ferrite to get manganese-zinc ferrite powder, adding a spherical poly(methyl methacrylate) particle powder agent containing benzoyl peroxide into the manganese-zinc ferrite powder, uniformly mixing, further adding methyl methacrylate containing dimethyl mercaptopropionic acid, and blending to prepare a product. The Curie temperature of the bone cement prepared by the preparation method disclosed by the invention is about 50 DEG C, the magnetic bone cement containing the manganese-zinc ferrite in the different proportions can raise the temperature from 37 DEG C to 50 DEG C and be constant at the temperature under an external alternating magnetic field, and the temperature control performance is realized.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a temperature-controlled magnetic bone cement and a preparation method thereof. Background technique [0002] The postoperative recurrence of bone tumors is a major problem in the medical field. Bone tumor recurrence not only makes patients suffer more, but can even be life-threatening. Due to the recurrence of bone tumors, people put forward requirements for tumor treatment functions on bone repair materials that originally only had bone repair and reconstruction functions. Bone cement is a kind of orthopedic repair material widely used clinically. It is generally obtained by mixing solid phase and liquid phase. [0003] Magnetic hyperthermia uses the characteristic that magnetic substances can convert the energy of an external magnetic field into heat energy under an alternating magnetic field. The magnetic induction medium material is conformally implanted or introduced into the pati...

Claims

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Application Information

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IPC IPC(8): C04B26/10A61L27/44A61L27/16A61L27/02A61L27/50
Inventor 李光大赵三团胡志刚马建华乔晓岚谢蟪旭
Owner HENAN UNIV OF SCI & TECH
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