Composite nanometer fiber film and preparation method thereof

A composite nanofiber and gelatin technology, which is applied in the direction of animal fiber, fiber treatment, fiber type, etc., can solve the problems of non-complementary or simultaneous existence of functions, unsafe costs, and functional limitations, etc., to achieve broad-spectrum antibacterial activity compatibility, The effect of good liquid absorption rate and good cell compatibility

Active Publication Date: 2016-08-24
CENT TESTING INT GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing nanofiber membranes used for wound dressings also have some shortcomings: their functions are limited or single, and the functions cannot be complementary or exist at the same time. For example, the nanofiber membrane wound dressings with strong antibacterial properties have cytotoxicity; In addition, in order to improve the strength of the fiber membrane, a chemical crosslinking agent is introduced, but it brings unsafe and cost-increasing problems

Method used

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  • Composite nanometer fiber film and preparation method thereof
  • Composite nanometer fiber film and preparation method thereof
  • Composite nanometer fiber film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] In a 100ml three-necked flask with a vacuum interface, a thermometer and mechanical stirring, 40g of polycaprolactone glycol (molecular weight 4000g / mol) and 3.6g of 1,4-butanediol were added. The oil bath is heated to 100 degrees, and vacuum dehydration is carried out at 100 Pa for 1.5 hours. After that, the vacuum is released and the temperature is reduced to 80 degrees Celsius. 12.5 g of MDI is added, stirred quickly for 20 seconds, and poured into a PTFE tray for curing in a 100 degrees oven for 24 Shape memory polyurethane can be obtained within hours.

Embodiment 2

[0035] Add 40g PBA (molecular weight 4000g / mol) into a 100ml three-necked flask with vacuum interface, thermometer and mechanical stirring. The oil bath is heated to 100 degrees, and vacuum dehydration is carried out at a vacuum of 100 Pa for 1.5 hours. After that, the vacuum is released and the temperature is lowered to 80 degrees Celsius. 5 g of MDI is added, and the reaction temperature is controlled to 80 degrees Celsius for 2 hours under the protection of nitrogen. Then, 65 g of DMAc was added to dissolve, and 30 g of DMAc solution containing 2% EDA was slowly added dropwise under stirring, and the reaction was continued for 2 hours to obtain a shape memory polyurethane solution. The shape memory polyurethane can be obtained by precipitating and drying the polyurethane solution in water.

[0036] It is understandable that the shape memory polyurethane can also adopt other temperature-sensitive shape memory polyurethanes whose crystallization-melting temperature is the transi...

Embodiment 3

[0039] Weigh 0.15g of chitosan with a molecular weight of 200,000, a degree of deacetylation of 85%, and a viscosity of 500mpa.s, 0.15g of gelatin with a molecular weight of 30,000 and a Bloom value of 200, and 0.70g of the shape memory prepared in Example 1. Polyurethane is dissolved in a mixed acidic solvent with a weight ratio of formic acid: glacial acetic acid = 1:1 to make its concentration 10%. Afterwards, the composite nanofiber membrane was prepared by the electrospinning method. The electrospinning parameters were: the voltage was 15kv, the distance between the nozzle and the collecting plate was 10cm, the rotation of the collecting plate was 10rpm, the temperature was 22±2℃, and the humidity was 35±3%. .

[0040] Finally, post-treatment is performed. The post-treatment step is: soak the composite nanofiber membrane in a concentration of 1*10 -5 mol / L silver sulfate solution for 3h; the environment is naturally dry.

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Abstract

The invention discloses a composite nanometer fiber film formed by compositing chitosan, gelatin and shape memory polyurethane; the chitosan and gelatin are prepared by the weight ratio of (0.5-2):1; the total weight of the chitosan and gelatin and the weight of the shape memory polyurethane are prepared by the ratio of (0.2-2):1; the composite nanometer fiber film preparation method comprises the following steps: dissolve the chitosan, gelatin and shape memory polyurethane into a solvent so as to obtain a homogeneous solution; using a static spinning method to process the homogeneous solution so as to obtain the composite nanometer fiber film; carrying out proper after treatment for the composite nanometer fiber film. The composite nanometer fiber film is good in cell compatibility, wide spectrum antibiosis activity, haemostasis performance, permeability, mechanical strength, shape memory function, water vapor transmittance, heat stability and imbibition rate, and can be applied as biology medical dressing.

Description

Technical field [0001] The invention relates to a shape memory polymer material, in particular to a composite nanofiber membrane material that can be used as a medical wound dressing. Background technique [0002] Electrospinning technology is one of the traditional and efficient nanofiber preparation methods, and it has played an important role in promoting the development of nanotechnology in recent years. At present, nanofiber membranes are generally non-woven membranes obtained through optimized electrospinning processes using polymer materials with certain functions and activities. Such non-woven membranes usually have better air permeability, better water vapor transmission rate, better liquid absorption and other functions. At the same time, they can have a structure and function similar to extracellular matrix, which can promote rapid damage to tissues. repair. Therefore, multifunctional nanofiber membranes have broad application prospects in the fields of medical wound...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4382D04H1/728A61L15/32A61L15/28A61L15/26A61L15/44A61L15/42D06M11/65D06M11/56D06M101/10D06M101/38
Inventor 胡金莲谭淋
Owner CENT TESTING INT GRP CO LTD
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