Rapid hemostatic hydrogel and preparation method thereof

A hydrogel and fast technology, which is applied in the fields of pharmaceutical formulation, application, and medical science, can solve the problems of low mechanical strength, low mechanical strength, and weak adhesion of hydrogel, and achieve good cell compatibility and high Mechanical strength, easy peeling effect

Active Publication Date: 2019-02-15
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Kim et al. used amino-modified polyethylene glycol and tannic acid to prepare a hydrogel that was physically cross-linked by hydrogen bonds, resulting in lower mechanical strength but complete hemostasis in a mouse liver model. Only 30 seconds, (Kim K, Shin M, Koh M, et al. Advanced Functional Materials, 2015, 25, 2402.)
[0004] However, the above-mentioned several hydrogels have low mechanical strength and weak adhesion in wet environment.

Method used

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  • Rapid hemostatic hydrogel and preparation method thereof
  • Rapid hemostatic hydrogel and preparation method thereof
  • Rapid hemostatic hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Add acrylamide (AM) (5 g) and nano-kaolin (KA) (0.03 g) to 12 g of deionized water at room temperature, stir for 6 h, and then ultrasonicate for 1 h to mix them evenly to obtain a mixed solution I; after transferring to an ice-water bath , add tannic acid (TA) (0.32g), N,N'-methylenebisacrylamide (12.5mg), ammonium persulfate (25mg) to the mixed solution I in turn, and stir for 20min to obtain the mixed solution II; The mixed solution II was added with accelerator tetramethylethylenediamine (20 μL) and stirred for 10 minutes, then transferred to a mold, and polymerized at 40°C for 8 hours to obtain a sample, numbered PAM-TA-KA1. The compressive strength, tensile strength and elongation at break are shown in Table 1, and the adhesion strength to different substrates is shown in Table 2.

Embodiment 2

[0030] Add AM (5g) and KA (0.07g) to 12g deionized water at room temperature, stir for 6 hours, and then ultrasonically mix them for 1 hour to obtain a mixed solution I; after transferring to an ice-water bath, add TA in turn to the mixed solution I (0.32g), N,N,-methylenebisacrylamide (12.5mg), ammonium persulfate (25mg) to obtain mixed solution II; after stirring for 20min, add accelerator tetramethylethylenediamine ( 20 μL), stirred for 10 minutes, transferred to a mold, and polymerized at 40°C for 8 hours to obtain a sample, numbered PAM-TA-KA2. The compressive strength, tensile strength and elongation at break are shown in Table 1, and the adhesion strength to different substrates is shown in Table 2.

Embodiment 3

[0032] Add AM (5g) and KA (0.10g) to 12g deionized water at room temperature, stir for 6 hours, and then ultrasonically mix them for 1 hour to obtain a mixed solution I; after transferring to an ice-water bath, add TA in turn to the mixed solution I (0.32g), N,N'-methylenebisacrylamide (12.5mg), ammonium persulfate (25mg) to obtain mixed solution II; after stirring for 20min, add accelerator tetramethylethylenediamine ( 20 μL), stirred for 10 minutes, transferred to a mold, and polymerized at 40°C for 8 hours to obtain a sample, numbered PAM-TA-KA3. The compressive strength, tensile strength and elongation at break are shown in Table 1, and the adhesion strength to different substrates is shown in Table 2.

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Abstract

The invention discloses a rapid hemostatic hydrogel. The rapid hemostatic hydrogel comprises acrylamide, inorganic nanoparticles, tannic acid, a crosslinking agent, an initiator and an accelerant, wherein the addition amount of the inorganic nanoparticles is 0.2-10% of the weight of the acrylamide; the addition amount of the tannic acid is 1-20% of the weight of the acrylamide; the addition amountof the crosslinking agent is 0.25-2% of the weight of the acrylamide; the addition amount of the initiator is 0.5-3% of the weight of the acrylamide; 20-40[mu]L of the accelerant is added into each 100g of the acrylamide. The rapid hemostatic hydrogel has the advantages as follows: 1, the rapid hemostatic hydrogel with wet tissue adhesion, prepared by a preparation method provided by the invention, can be firmly adhered to a body tissue without relying on an additional adhesive, an additional bandage and the like during using, can maintain good adhesion strength during repeated use, and is very easy to strip; 2, the hemostatic hydrogel material has relatively high mechanical strength, has the elongation at break as high as 2200% and the compressive strength of 10.15MPa plus or minus 0.36MPa, and can meet surgical requirements.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a formula of rapid hemostatic hydrogel, a preparation method and application thereof. Background technique [0002] Rapid hemostasis materials can effectively control the bleeding of traumatic wounds, thereby effectively reducing the mortality rate of traumatic bleeding wounded in wars and daily accidents. According to the mechanism of hemostasis: the coagulation process can be divided into three types, the intrinsic coagulation pathway, the extrinsic coagulation pathway and the common coagulation pathway. People can achieve rapid hemostasis in two ways: one is to promote vasoconstriction, narrow the lumen, and slow down the blood flow at the injured site. The second is to quickly activate coagulation factors and accelerate the coagulation cascade reaction. The hemostatic materials used at home and abroad are mainly inorganic materials and polymer materials. The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/02A61L24/00C08F220/56C08F222/38C08F222/20C08F2/44C08K3/34C08K3/32C08K3/36
CPCA61L24/001A61L24/0031A61L24/02A61L24/06A61L2400/04C08F2/44C08F220/56C08K3/32C08K3/346C08K3/36C08K2003/325C08K2201/011C08L33/26C08F222/102
Inventor 刘海清范先谋李培源
Owner FUJIAN NORMAL UNIV
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