Substituted isoindoline-1,3-dione derivative

Abstract

The invention relates to a novel substituted isoindoline-1,3-dione derivative and the pharmaceutically acceptable salts thereof. More particularly, the invention relates to a novel substituted isoindoline-1,3-dione derivative used as an analogue of apremilast. The invention further provides a composition containing the compound disclosed by the invention and a carrier, and the application of the disclosed compound and composition in a method for beneficially treating diseases and conditions by administering apremilast.

Description

Background technique

[0001] Many existing drugs suffer from poor absorption, distribution, metabolism and / or excretion (ADME) properties, which prevent their wider use or limit their use in specific indications. Poor ADME properties are also the main reason why drug candidates fail in clinical trials. Although formulation techniques and prodrug strategies can in some cases be used to enhance certain ADME properties, these approaches often fail to address fundamental ADME problems that exist for many drugs and drug candidates. One such problem is rapid metabolism that causes many drugs that are otherwise very effective in treating disease to be cleared too quickly from the body. A possible solution for rapid drug clearance is frequent or high dose dosing to achieve sufficiently high drug plasma levels. However, this introduces many potential treatment problems, such as poor patient compliance with the dosing regimen, higher doses leading to more severe side effects and increa...

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