Preparation method of sodium carboxymethyl starch

A technology of carboxymethyl starch sodium and cross-linking reaction, which is applied in the field of preparation of carboxymethyl starch sodium, can solve problems such as slow disintegration speed, and achieve the effects of promoting dissolution speed, improving bioavailability, and strong water-absorbing swelling

Active Publication Date: 2012-07-25
ANHUI SUNHERE PHARMA EXCIPIENTS
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Problems solved by technology

[0003] The object of the present invention is to provide a kind of preparation method of carboxymethyl starch sodium, the existing preparation method is improved for the slow disintegration speed defect that exists when ordinary type carboxymethyl starch sodium is used as a disintegrant, aiming at Provide a carboxymethyl starch sodium with high sodium content and fast disintegration speed

Method used

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Embodiment Construction

[0012] The present invention is realized like this, and the method steps are:

[0013] 1) Cross-linking reaction: According to the ratio of raw materials, 1400 kg of ethanol with a mass fraction of 95% required for feeding is pumped into the reaction kettle, and after stirring, the prescribed amount of 14 kg of alkali solid sodium hydroxide is first put into the reaction kettle, Heat up to 45°C, put in 300kg of corn starch, add 300ml of cross-linking agent epichlorohydrin, heat up to 35°C-45°C, and react for 30 minutes;

[0014] 2) etherification reaction: after the cross-linking reaction finishes, drop into 44kg of chloroacetic acid, stir for 10 minutes, then pump in 1400kg of ethanol whose mass fraction is 95%, 26kg of flake alkali, be warming up to 60 ℃-64 ℃, heat preservation reaction 240 minutes;

[0015] 3) Neutralization reaction ： After the etherification is completed, the temperature is lowered to below 40 ° C and put into hydrochloric acid for neutralization, the pH...

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Abstract

The invention discloses a preparation method of sodium carboxymethyl starch. The preparation method comprises the following steps of: (1) performing cross-linking reaction; (2) performing etherification reaction; (3) performing neutralization reaction; (4) centrifuging; (5) drying; and (6) sieving and packaging. The preparation method has the technical effects that: the sodium content of the sodium carboxymethyl starch prepared by the preparation method is greater than 2.9; strong water absorbing expansion is guaranteed; the dissolution rate of a medicament is promoted; and the bioavailability of the medicament is greatly improved.

Description

technical field [0001] The invention relates to a preparation method of carboxymethyl starch sodium. Background technique [0002] At present, carboxymethyl starch sodium has been widely used as a disintegrant in the production of solid preparations. There are many domestic manufacturers of this product, but the quality control indicators are not fine enough, and its disintegration performance varies greatly. After moderate cross-linking reaction, the starch is etherified with monochloroacetic acid under suitable alkaline conditions to control its sodium content and viscosity, so that products with excellent performance can be obtained. In recent years, the research level, production technology and product quality of CMS sodium content between 2.0 and 2.4 have basically matured, but the industrial production of carboxymethyl starch sodium with high content (sodium content > 2.8) is still basically blank in China, and the quality There is a big gap between stability and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B31/12
Inventor 李杰丁增华周卫东朱岩陈晓雪张学全毕勇
Owner ANHUI SUNHERE PHARMA EXCIPIENTS
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