Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for enhancing oxidation resistance of oily medicament

A technology of antioxidant capacity and drug, applied in the directions of pharmaceutical formulations, plant raw materials, organic active ingredients, etc., can solve problems such as difficult combination, and achieve the effects of preventing drug inactivation, reducing breakage, and mild preparation process conditions.

Inactive Publication Date: 2013-03-13
HEILONGJIANG UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problem that the existing oily medicines are not easy to be combined with other powdered medicines after adopting anti-oxidation protection measures, and provides a method for improving the antioxidant capacity of oily medicines

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for enhancing oxidation resistance of oily medicament

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0026] Specific embodiment one: in this embodiment, a method for improving the antioxidant capacity of oily medicine is carried out according to the following steps:

[0027] 1. Weigh 1-2 parts of chitosan, 1-2 parts of carboxymethylcellulose sodium, 0.2-6 parts of oily medicine, 0.01-0.6 parts of emulsifier and 0.1-2 parts of curing agent according to the ratio of parts by mass;

[0028] 2. Dissolve the chitosan weighed in step 1 in an acetic acid solution, heat it in a water bath with a temperature of 50 to 55° C. to dissolve it and adjust the pH value to 1.6 to 2.4 to obtain a chitosan solution;

[0029] 3. Dissolve the sodium carboxymethyl cellulose weighed in step 1 in the acetic acid solution, heat it in a water bath with a temperature of 50-55°C to dissolve it and adjust the pH value to 1.6-2.4 to obtain a sodium carboxymethyl cellulose solution ;

[0030] 4. Add the oily medicine and emulsifier weighed in step 1 and the chitosan solution obtained in step 2 into a high...

specific Embodiment approach 2

[0044] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the ratio of the quality of chitosan and the volume of acetic acid solution in step two is (0.2~0.8g): 1mL. Other steps and parameters are the same as in the first embodiment.

specific Embodiment approach 3

[0045] Specific embodiment three: the difference between this embodiment and specific embodiment one is: the ratio of the quality of chitosan and the volume of acetic acid solution in step one is (0.4~0.6g): 1mL. Other steps and parameters are the same as in the first embodiment.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for enhancing the oxidation resistance of an oily medicament, which relates to a method for enhancing the oxidation resistance of an oily medicament and is used for solving the problem that the conventional oily medicament is difficult to combine with other powdery medicament after the adoption of an anti-oxidation protective measure. The method is implemented by the following steps of: I, weighing chitosan, sodium carboxymethylcellulose, an oily medicament, an emulsifier and a curing agent according to parts by mass; II, dissolving the chitosan and sodium carboxymethylcellulose into an acetic acid solution to obtain a chitosan solution and a sodium carboxymethylcellulose solution respectively; IV, adding the oily medicament, the emulsifier and the chitosan solution into a high-shear emulsifier to obtain an emulsion; V, dripping the sodium carboxymethylcellulose solution into the emulsion to obtain a mixture; and VI, adjusting the pH value of the mixture with ammonia water to obtain a compound, adding the curing agent to obtain a solid-phase substance, and performing washing, suction filtration and drying on the solid-phase substance. The method can be applied in the fields of biomedical engineering, chemical industry, medicine and the like.

Description

technical field [0001] The invention relates to a method for improving the antioxidant capacity of oily medicines. Background technique [0002] In recent years, microcapsule technology has been widely used in fields such as biomedical engineering, chemical industry, medicine, spices, cosmetics, pressure-sensitive copying paper, and liquid crystals. Both hydrophilic and lipophilic substances can be encapsulated. Microencapsulation has the functions of improving the physical properties of the core material, protecting the core material, preventing drug inactivation, reducing irritation, reducing incompatibility of compound preparations, and slowing down and controlling release. [0003] Oily medicines are volatile and easily oxidized in the air, so measures need to be taken to protect them. At present, easily oxidized oily drugs are often made into capsules, dropping pills and soft capsules. Although these dosage forms have improved the antioxidant capacity of medicine to ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/38A61K31/085A61K36/185A61K31/355A61K31/216A61K31/045
Inventor 赵学玲邢秀丽李强龚显峰张华
Owner HEILONGJIANG UNIV