Compound milbemycin oxime nanoemulsion anti-parasite medicine and preparation method thereof

A mebemycin oxime and anti-parasitic technology, which is applied in the field of compound mebemycin oxime nano-emulsion anti-parasitic drugs and its preparation, can solve problems such as unsound drugs, increase drug loading, and facilitate popularization and application , a wide range of effects

Inactive Publication Date: 2012-08-01
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] With the rapid development of the economy and the improvement of people's living standards, more and more people start to raise pets. However, the medicines that can be ...

Method used

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  • Compound milbemycin oxime nanoemulsion anti-parasite medicine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) Weigh 29.6g of Tween-80, 12.2g of cinnamaldehyde, 2.6g of mebemycin oxime, 0.7g of levamisole, and 54.9g of distilled water according to the proportion of the formula, and set aside;

[0055] (2) Add 2.6g of mebemycin oxime to 12.2g of cinnamaldehyde, stir to fully dissolve it, and use it as the oil phase;

[0056] (3) Add 0.7g of levamisole to 54.9g of distilled water, stir to fully dissolve it, and use it as the water phase;

[0057] (4) Stir the oil phase and the surfactant rapidly at room temperature, slowly add the water phase dropwise while stirring, and keep stirring until the system becomes a transparent and clear liquid, and the compound mebemycin oxime nanoemulsion is obtained.

Embodiment 2

[0058] Example 2 A compound mebemycin oxime nanoemulsion antiparasitic drug, the quality of each component:

[0059] EL-40 28.8g, triacetin 10.7g, mebemycin oxime 1.2g, levamisole 0.3g, distilled water 59.0g.

Embodiment 3

[0060] Example 3 A compound mebemycin oxime nanoemulsion antiparasitic drug, the quality of each component:

[0061] RH-40 37.5g, castor oil 3.5g, mebemycin oxime 0.8g, levamisole 0.2g, distilled water 59.0g.

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Abstract

The invention discloses a compound milbemycin oxime nanoemulsion anti-parasite medicine and a preparation method thereof. The diameter of a liquid drop of the nanoemulsion medicine ranges from 1nm to 100nm, the medicine is composed of the following raw materials by mass: milbemycin oxime 0.5%-3.5%, levamisole 0.1%-0.5%, a surface active agent 23.5%-38.5%, oil 3.0%-17.0%, the remaining part is distilled water, and the sum of the mass percentage of the raw materials is 100%. The nanoemulsion preparation is clear and transparent liquid, has good stability and fast absorption, is released to targets, has the advantages of high efficiency, broad spectrum, low toxicity and the like, is a medicine for preventing and treating internal and external parasites of pets, and is mainly used for preventing and treating dirofilariasis and removing internal parasites of nematodes, hookworms, roundworms, whipworms and the like and external parasites of itch mites, nasal mites, hair follicle mites, louses, fleas and the like. The compound milbemycin oxime nanoemulsion anti-parasite medicine solves the problem of water insolubility of milbemycin oxime, is simple in preparation process, high in safety and convenient to popularize.

Description

technical field [0001] The invention belongs to the field of veterinary medicines, and relates to a new dosage form of an antiparasitic medicine, in particular to a compound mebemycin oxime nanoemulsion antiparasitic medicine for preventing and treating internal and external parasites of pets and a preparation method thereof. [0002] Background technique [0003] With the rapid development of the economy and the improvement of people's living standards, more and more people start to raise pets. However, the medicines that can be specially used for pets are not yet perfect in the market. Once pets are infected with diseases, the biggest threat is humans. Therefore, it is imminent to develop new pet medicines. [0004] Milbemycin Oxime (Milbemycin Oxime) is a macrolide antiparasitic drug, it is Milbemycin A 4 and A 3 Semi-synthetic derivatives. In 1975, it was isolated from the fermentation product of Streptomyces by the scientists of Sankyo Company in Japan. The United ...

Claims

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Application Information

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IPC IPC(8): A61K31/429A61K31/365A61K9/107A61P33/14
Inventor 欧阳五庆郑星星欧阳伸雨
Owner NORTHWEST A & F UNIV
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