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Curcumin suspension and preparation method thereof

A technology of curcumin and suspensions, applied in the direction of anti-toxic agents, anti-inflammatory agents, anti-viral agents, etc., which can solve the problems of limited application, short metabolic half-life, and low oral bioavailability

Inactive Publication Date: 2012-08-08
LINYI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because curcumin is a lipophilic substance, it is insoluble in water, easily oxidized in vitro, easily degraded in the digestive tract and has a short metabolic half-life in vivo, and low oral bioavailability; although there are curcumin solid dispersions and transdermal absorption preparations , microspheres, soft capsules and other dosage forms (Zhong Mingyuan et al., Research Progress in Curcumin Formulations, Chinese Patent Medicine, 2007, 29(2): 255-257) and corresponding research on modified structures have improved absorption and improved biological Utilization, but due to factors such as process and cost, its application in production and clinical application is limited

Method used

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  • Curcumin suspension and preparation method thereof
  • Curcumin suspension and preparation method thereof
  • Curcumin suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: the preparation of curcumin suspension

[0036] prescription:

[0037] components

[0038] Preparation method: According to the prescription, weigh the suspending agent (sodium carboxymethylcellulose, PVP k-30) into a beaker, add an appropriate amount of water, and leave it overnight for about 12 hours until it swells completely to obtain a swelling solution. Weigh curcumin powder and put it in a mortar, add wetting agent (glycerin, poloxamer), grind it repeatedly for about 10 minutes to a very fine and uniform powder, slowly add the above swelling solution, grind evenly, and then transfer it to a 100mL stoppered measuring cylinder , Rinse the mortar and other utensils with distilled water several times, also transfer to a stoppered measuring cylinder, add distilled water to 100g, seal the mouth of the cylinder, turn up and down and shake for the same number of times, mix evenly, and obtain a curcumin suspension.

Embodiment 2

[0039] Embodiment 2: the preparation of curcumin suspension

[0040] prescription:

[0041] components

[0042] Glycerin

[0043] Preparation method: with embodiment 1.

Embodiment 3

[0044] Embodiment 3: the preparation of curcumin suspension

[0045] prescription:

[0046] components

[0047] Preparation method: with embodiment 1.

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PUM

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Abstract

The invention relates to a curcumin suspension, which comprises the following components in parts by weight: 0.1-2.0 parts of curcumin, 0.5-6.5 parts of a suspending agent, 0.1-12.0 parts of a wetting agent, 0-5.5 parts of a solubilizing agent and 83.5-97.5 part of water, wherein the suspending agent is selected from one or more of sodium carboxymethylcellulose, polyvinylpyrrolidone and poloxamer; and the wetting agent is prepared from one or more of glycerol, polyethylene glycol, poloxamer and polyvinylpyrrolidone. The invention further provides a preparation method of the suspension. The curcumin suspension is in the form of a novel curcumin liquid preparation, and can be taken through oral administration, injection or external administration.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a curcumin suspension. The invention also relates to a preparation method of the curcumin suspension. Background technique [0002] Curcumin (Curcumin, Cur) is a phenolic pigment extracted from the rhizome of turmeric (curcumalonga), a plant of the genus Curcuma in the ginger family. It is widely used as a pigment and food additive, and curcumin can protect normal cells from various adverse factors. Based on the damage of curcumin, it exerts various biological activities and pharmacological effects such as anti-inflammation, anti-tumor, anti-oxidation, anti-bacterial, anti-virus, etc. , 12(2):526). However, because curcumin is a lipophilic substance, it is insoluble in water, easily oxidized in vitro, easily degraded in the digestive tract and has a short metabolic half-life in vivo, and low oral bioavailability; although there are curcumin solid dispersions and trans...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/12A61P29/00A61P35/00A61P39/06A61P31/04A61P31/12
Inventor 高振珅廉开美薛艳飞薛蕾
Owner LINYI UNIVERSITY