Phellinus linteus polysaccharide oral liposome medicine and preparation technology thereof

A liposome, Phellinus linteus technology, applied in liposome delivery, drug combination, anti-tumor drugs, etc., can solve the problem of low bioavailability, short duration of effective blood drug concentration, and lack of targeting of Phellinus linteus polysaccharides. and other problems, to achieve the effect of increasing blood drug concentration and prolonging half-life

Active Publication Date: 2012-08-15
山东省循证医学研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in many cases, Phellinus polysaccharide cannot achieve its expected pharmacological activity after entering the human body
This is mainly due to the fact that most of Phellinus polysaccharides have been metabolized before reaching the lesion, resulting in low bioavailability and short maintenance time of effective blood drug concentration, and Phellinus polysaccharides do not have the targeting of the lesion. This is a major difficulty in preparing medicines from Phellinus polysaccharides

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh 400mg of soybean lecithin, 100mg of cholesterol, 50mg of sodium taurodeoxycholate and 20mg of vitamin E, add it to 8ml of absolute ethanol, and dissolve it in a short-term water bath ultrasonically to form an organic phase; dissolve 100mg of Phellinus polysaccharide in 50ml In 0.01M pH7.4 phosphate buffer solution, ultrasonically dissolve it in a short-term water bath to form a water phase; quickly and evenly inject the organic phase into the continuously stirring 60°C water phase, stir for a period of time, evaporate the organic solvent, and prepare The obtained primary liposome suspension is directly passed through a high-pressure homogenizer (2 times when the pressure is 500 bar, and 2 times when the pressure is 1000 bar), and the protective agent trehalose is added in the obtained secondary liposome suspension. , spray-dried to obtain liposome dry powder.

Embodiment 2

[0029] Weigh 400mg of soybean lecithin, 50mg of cholesterol, 100mg of sodium taurodeoxycholate and 20mg of vitamin E, add it to 8ml of absolute ethanol, and dissolve it in a short-term water bath ultrasonically to form an organic phase; dissolve 100mg of Phellinus polysaccharide in 50ml In 0.01M pH7.4 phosphate buffer solution, ultrasonically dissolve it in a short-term water bath to form a water phase; quickly and evenly inject the organic phase into the continuously stirring 60°C water phase, stir for a period of time, evaporate the organic solvent, and prepare The obtained primary liposome suspension is directly passed through a high-pressure homogenizer (2 times when the pressure is 500 bar, and 2 times when the pressure is 1000 bar), and the protective agent trehalose is added in the obtained secondary liposome suspension. , spray-dried to obtain liposome dry powder.

Embodiment 3

[0031] Weigh 400mg of soybean lecithin, 100mg of cholesterol, 50mg of sodium taurodeoxycholate and 20mg of vitamin E, add it to 4ml of absolute ethanol, and dissolve it by ultrasonication in a short-term water bath to form an organic phase; dissolve 100mg of Phellinus polysaccharide in 50ml In 0.01M pH7.4 phosphate buffer solution, ultrasonically dissolve it in a short-term water bath to form a water phase; quickly and evenly inject the organic phase into the continuously stirring 60°C water phase, stir for a period of time, evaporate the organic solvent, and prepare The obtained primary liposome suspension is directly passed through a high-pressure homogenizer (2 times when the pressure is 500 bar, and 2 times when the pressure is 1000 bar), and the protective agent trehalose is added in the obtained secondary liposome suspension. , spray-dried to obtain liposome dry powder.

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Abstract

The present invention relates to a Phellinus linteus polysaccharide oral liposome medicine and a preparation technology thereof. By encapsulating the Phellinus linteus polysaccharide by a liposome, after the Phellinus linteus polysaccharide is orally taken and enters the digestive system, the encapsulated Phellinus linteus polysaccharide is prevented from being destroyed by gastric juice, bile and the like, and effectively delivered to the absorption site, therefore, the blood drug level of the Phellinus linteus polysaccharide is increased, and the half-life period of the Phellinus linteus polysaccharide is prolonged. Compared with the Phellinus linteus polysaccharide which is not encapsulated by the liposome, the Phellinus linteus polysaccharide encapsulated by the liposome has the advantages that the blood drug level is increased and the half-life period is obviously prolonged.

Description

technical field [0001] The invention relates to an oral liposome drug of Phellinus polysaccharide, in particular to an industrially scalable preparation process of the liposome, and belongs to the technical field of extraction and application of active ingredients of traditional Chinese medicines. Background technique [0002] Phellinus japonica, also known as hozen eye, mulberry ear, and pinfora, belongs to Basidiomycotina, Phyllomycetes, Polyporacea, and Polyporaceae. It uses fruiting bodies as medicine and is a fungus growing on mulberry trees. Phellinus Phellinus has extremely high medicinal value and is known as "forest gold". It has been used as a Chinese medicinal material in my country for more than 2,000 years since the Han Dynasty. China's earliest materia medica book "Shen Nong's Materia Medica" has already recorded the medicinal effect of "Mulberry Parasitic", and "Compendium of Materia Medica" records that Phellinus can "strengthen the five internal organs, prom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K9/14A61K9/19A61K31/715A61K47/28A61P35/00
Inventor 滕利荣吴丽艳金元宝王艳珍王立英张瑶刘明石孟凡欣杨东生赵明智
Owner 山东省循证医学研究院
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