Compound omeprazole capsule and preparation method thereof

Abstract

The invention relates to a compound omeprazole capsule and a preparation method thereof. The capsule consists of omeprazole, sodium bicarbonate and pharmaceutically acceptable officinal carrier, the pH value of the stomach environment can be increased, and the pH value can be maintained for a certain time due to the sodium bicarbonate, so that the omeprazole which is unstable when meets acid is absorbed for taking effect quickly before being damaged by gastric acid. The compound omeprazole capsule is characterized in that the granularity of one of the main medicine compositions, the omeprazole, is controlled to be in a certain range, so that the prepared preparation, namely omeprazole, can be dissolved and absorbed rapidly in the stomach environment and rapidly and quickly plays the role of inhibiting the gastric acid secretion so as to achieve the ideal curative effects.

Description

technical field [0001] The invention relates to a capsule of compound omeprazole and a preparation method thereof. The preparation is composed of omeprazole, sodium bicarbonate and a pharmaceutically acceptable carrier. Background technique [0002] Omeprazole is a proton pump inhibitor drug used to treat heartburn and other symptoms of gastroesophageal reflux disease, and can also be used for short-term maintenance treatment of duodenal ulcer and reflux esophagitis. Omeprazole inhibits gastric acid secretion by inhibiting the H+ / K+ATPase system on the surface of gastric parietal cells; sodium bicarbonate is weakly alkaline, and it is an antacid in this product, which has the effect of neutralizing gastric acid. [0003] Because omeprazole is easily degraded in gastric acid, the omeprazole preparations currently on the market in China are all enteric-coated preparations. The enteric-coated method is used to protect the drug from being degraded by gastric acid, but it delays ...

AI Technical Summary

Problems solved by technology

[0003] Because omeprazole is easily degraded in gastric acid, the omeprazole preparations currently on the market in China are all enteric-coated preparations. The enteric-coated method is used to protect the drug from being degraded by gastric acid, but it delays the absorption and absorption of the drug. Initial inhibitory effect on gastric acid

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