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Andrographolide compound

A technology of Yanhuning and compounds, applied in the field of pharmaceutical compounds, to achieve the effects of improving purity, reducing oxidation, and good stability

Active Publication Date: 2013-05-01
珠海晨安医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But this invention does not measure the stability of prepared Yanhuning

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0035] Embodiment 1: Preparation of Yanhuning crystal

[0036] The preparation method of Yanhuning crystal of the present invention comprises the following steps:

[0037] (1) Take 300g of Chuanhuning solid in a reactor, add 1L of water and stir to make a suspension, cool to 1°C, and stir to obtain a white suspension;

[0038] (2) Add 1°C, 1mol / L aqueous sodium bicarbonate solution, stir while adding, control the pH value to 7.0, and obtain a transparent solution; replace the air in the reactor with nitrogen during the dropping process; stirring speed 60 rpm ;

[0039] (3) Warm up the solution to 6° C., add activated carbon, and stir for 1.5 hours; filter with suction, collect the filtrate, and obtain Yanhuning solution; the proportion of activated carbon added is 0.05% of the solution mass;

[0040] (4) At 1°C, in a 5L reactor, add a sound field with a frequency of 25KHz and an output power of 30W, add 4L of a mixed solution of ethanol and ether while stirring, stop the sou...

Embodiment 2

[0042] Embodiment 2: the preparation of Yanhuning crystal

[0043] (1) Take 100g of Chuanhuning solid in a reactor, add 5L of water and stir to make a suspension, cool to 6°C, and stir to obtain a white suspension;

[0044] (2) add 5 ℃, 1mol / L sodium bicarbonate aqueous solution, stir while adding, control pH value to be 7.0, obtain transparent solution; Replace the air in the reactor with nitrogen in the dropwise addition process; Stirring speed is 60 rev / minute;

[0045] (3) Warm up the solution to 8° C., add activated carbon, and stir for 1 hour; filter with suction, collect the filtrate to obtain Yanhuning solution; the proportion of activated carbon added is 0.1% of the solution mass;

[0046] (4) At 4°C, in a 20L reactor, add a sound field with a frequency of 25KHz and an output power of 80W, add 10L of a mixed solution of ethanol and ether dropwise while stirring, stop the sound field after adding the mixed solution, and let it stand The crystal was grown for 6 hours...

Embodiment 3

[0048] Embodiment 3: the preparation of Yanhuning crystal

[0049] (1) Take 400g of Chuanhuning solid in a reactor, add 2L of water and stir to make a suspension, cool to 6°C, and stir to obtain a white suspension;

[0050] (2) add 6 ℃, 1mol / L sodium bicarbonate aqueous solution, stir while adding, control pH value to be 7.0, obtain transparent solution; Replace the air in the reactor with nitrogen in the dropwise addition process; Stirring speed is 45 rpm minute;

[0051] (3) Warm up the solution to 10°C, add activated carbon, and stir for 1 hour; filter with suction, collect the filtrate to obtain Yanhuning solution; the ratio of added activated carbon is 0.02% of the solution mass;

[0052] (4) At 6°C, in a 10L reactor, add a sound field with a frequency of 25KHz and an output power of 50W, add 6L of a mixed solution of ethanol and ether dropwise while stirring, stop the sound field after adding the mixed solution, and let it stand Cultivate the crystal for 7 hours; filte...

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Abstract

The invention relates to a medicinal compound, in particular relates to an andrographolide compound. The andrographolide compound is crystal, and has characteristic peaks when the 2 theta of X-ray powder diffraction measured by using Cu-K alpha rays is 12.3 degrees, 13.5 degrees, 14.0 degrees, 14.8 degrees, 16.1 degrees, 17.0 degrees, 17.7 degrees, 18.3 degrees, 19.1 degrees, 19.8 degrees, 21.2 degrees, 21.9 degrees, 22.7 degrees, 23.4 degrees, 24.5 degrees, 25.8 degrees, 27.1 degrees, 28.3 degrees, 28.9 degrees and 30.0 degrees. The main granularity of the andrographolide compound crystal is40 to 70 microns, and the distribution width is 20 to 90 microns; and preferably the main granularity is 45 to 70 microns, and the distribution width is 25 to 90 microns. The andrographolide compoundis high in stability, high in purity and suitable for preparing a medicinal composition.

Description

technical field [0001] The invention relates to a pharmaceutical compound, in particular to a crystal compound of Yanhuning. Background technique [0002] Yanhuning, the chemical name is: 14-dehydroxy-11,12-didehydroandrographolide-3,19-disuccinic acid half ester potassium sodium salt monohydrate, the molecular formula is: C 28 h 34 KNaO 10 ·H 2 O. This strain is refined from Andrographis paniculata extract through esterification, dehydration and salt formation. Can inhibit early capillary permeability increase and inflammatory exudation and edema, can specifically stimulate the pituitary-adrenal cortex function, promote the release of ACTH, and increase the biosynthesis of ACTH in the anterior pituitary; it has inactivated adenovirus, influenza in vitro Viruses, respiratory viruses and other viruses can improve the body's defense and resistance to diseases, and comprehensively treat the damage caused by various bacteria and viruses to the human body. [0003] Due to p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/58A61K31/365A61P7/00A61P7/10A61P5/38A61P31/12A61P31/16A61P11/00A61P37/04A61P31/04
Inventor 黄金秀
Owner 珠海晨安医药有限公司
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