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Compound dehydration and diuresis medicine composition

A composition and drug technology, applied in the direction of drug combination, active ingredients of hydroxyl compounds, pharmaceutical formulations, etc., can solve problems such as difficult to effectively avoid adverse reactions, achieve long-lasting effects, reduce side effects, and restore energy metabolism

Active Publication Date: 2012-09-12
ZHUHAI HEFAN MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese invention patent application 200410038074 discloses a mannitol-fructose compound dehydrating and diuretic pharmaceutical composition, which can improve and restore the energy metabolism of important organs such as the heart, brain, and kidneys during hypoxia, and prevent mannitol from damaging the kidneys ; But the content of mannitol in the compound is preferably about 15%, and the content is still relatively high, so it is difficult to effectively avoid the use of mannitol injection to bring serious adverse reactions

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  • Compound dehydration and diuresis medicine composition

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Embodiment Construction

[0026] The technical solutions of the present invention will be further described below in conjunction with specific embodiments.

[0027] Compound anhydrating diuretic pharmaceutical composition of the present invention can be made by following method:

[0028] Components such as mannitol, piracetam, 1,6-diphosphate fructose and glucose, hydrochlorothiazole weighed according to the mass percentage are dissolved in deionized water, filtered, and the content of the semi-finished product is measured, and the pH value (3.0- 5.0), subpackage after fine filtration, and then sterilize to make finished products. Sterilization can be done by steam sterilization at 100°C for 30 minutes. The following are the formula ratios of each component of each specific embodiment and comparative example, see Table 1 for details.

[0029] Table 1 specific example formula (unit: wt %)

[0030]

[0031] *The pharmacologically acceptable salts are 0.5wt% sodium chloride, 0.23wt% sodium lactate, ...

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Abstract

The invention relates to a compound dehydration and diuresis medicine composition, which contains mannitol, piracetam, 1,6-fructose diphosphate, pharmacological acceptable carriers, glucose and hydrogen chloride thiazole. The compound dehydration and diuresis medicine composition uses mannitol, piracetam and 1,6-fructose diphosphate as the main components, is fast in dosing and long in lasting time and can remarkably reduce using amount of mannitol and piracetam through synergistic effects simultaneously, so that side effects caused by mannitol and piracetam can be remarkably reduced, and thecompound dehydration and diuresis medicine composition is suitable for prevention and treatment of intracranial hypertension.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition, more specifically, the present invention relates to a kind of compound dehydration diuretic pharmaceutical composition, especially suitable for wounds such as traumatic brain injury, cerebral hemorrhage, cerebral infarction, meningitis, brain tumor, carbon monoxide poisoning, glaucoma, etc. Treatment of intracranial pressure or elevated intracranial pressure following brain surgery. Background technique [0002] After traumatic brain injury, cerebral hemorrhage, cerebral infarction, meningitis, brain tumor and other injuries and brain surgery, patients have different degrees of increased intracranial pressure due to brain parenchymal edema or space-occupying lesions. The degree and duration of increased intracranial pressure have a significant impact on the outcome and prognosis of the disease, and should be treated promptly and effectively. At present, the commonly used dehydratin...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61K31/4015A61K31/047A61P7/10A61P27/06
Inventor 和光学樊伟
Owner ZHUHAI HEFAN MEDICINE