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Crystal forms of 2-aminoethyl sulfonic acid and preparation processes for crystal forms

A technology of aminoethanesulfonic acid and crystal form, applied in the field of crystal form and preparation of 2-aminoethanesulfonic acid, can solve the problems of no in-depth study of crystal form, low yield, high cost, etc., and achieve the effect of good druggability

Active Publication Date: 2014-02-19
NANJING YOKO PHARMA GRP CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Documents such as CN101811995A and CN101838226A disclose methods for extracting natural 2-aminoethanesulfonic acid from fish and shellfish (such as squid, clams, etc.), and these methods often require steps such as raw material crushing, impurity removal, ion exchange, and concentration. Complex, high cost, low yield
[0024] However, the above documents only describe the synthesis and / or purification methods of 2-aminoethanesulfonic acid, without in-depth research on its crystal form, and there is no report of crystal form data

Method used

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  • Crystal forms of 2-aminoethyl sulfonic acid and preparation processes for crystal forms
  • Crystal forms of 2-aminoethyl sulfonic acid and preparation processes for crystal forms
  • Crystal forms of 2-aminoethyl sulfonic acid and preparation processes for crystal forms

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Embodiment 1

[0044] The preparation of embodiment 1 2-aminoethanesulfonic acid

[0045]According to the method disclosed in JP61282354A, 847.3 g of 2-aminoethanesulfonic acid was prepared and set aside.

Embodiment 22

[0046] The preparation of embodiment 22-aminoethanesulfonic acid crystal form I

[0047] Pick Example 1 50g of the prepared 2-aminoethanesulfonic acid was dissolved in 150ml of water, heated under reflux, decolorized with activated carbon for 30min, and suction filtered while it was hot. The filtrate was cooled to 5°C for crystallization, filtered with suction, washed with water, and dried under vacuum at 60-80°C. 31.4 g of crystalline form I of 2-aminoethanesulfonic acid were obtained.

Embodiment 3

[0048] Example 3 Preparation of 2-aminoethanesulfonic acid crystal form I

[0049] Pick Example 1 50g of the prepared 2-aminoethanesulfonic acid was dissolved in 100ml of water, heated under reflux, decolorized with activated carbon for 30min, and suction filtered while it was hot. The filtrate was cooled to 10°C for crystallization, filtered with suction, washed with water, and dried under vacuum at 60-80°C. 32.1 g of crystalline form I of 2-aminoethanesulfonic acid were obtained.

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Abstract

The invention mainly relates to crystal forms of 2-aminoethyl sulfonic acid and preparation processes for the crystal forms. 2-aminoethyl sulfonic acid is crystallized by water to form a crystal form I of the 2-aminoethyl sulfonic acid, and the crystal form I has characteristic diffraction peaks when 2 theta is about 12.23 degrees, 13.57 degrees, 22.48 degrees and 23.77 degrees on an X-ray powder diffraction pattern through Cu-K alpha ray detection; and the 2-aminoethyl sulfonic acid is crystallized by a mixed solvent to form a crystal form II of the 2-aminoethyl sulfonic acid, and the crystal form II has characteristic diffraction peaks when 2 theta is about 13.62 degrees and 16.90 degrees on the X-ray powder diffraction pattern through Cu-K alpha ray detection. The crystal form I and the crystal form II have advantages of high stability and high druggability, and are suitable to be prepared into medicinal formulations.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to the crystal form and preparation process of 2-aminoethanesulfonic acid. Background technique [0002] 2-Aminoethyl sulfonic acid (Cas №:107-35-7) was isolated from ox bile by Tidman and Gmelin in 1827, so it is also known as taurine, taurocholic acid or ox bile The chemical structure is shown below. [0003] [0004] 2-Aminoethanesulfonic acid widely exists in animal tissues and does not participate in the synthesis of proteins, but a special amino acid that is free outside the cells and can participate in maintaining the homeostasis of the body. The normal performance of the physiological functions of the system plays an important regulatory role. Specifically, 2-aminoethanesulfonic acid has the functions of choleretic, liver protection, detoxification, anti-inflammatory, antipyretic, sedative, anticonvulsant, antiarrhythmia, treatment of myocardial insufficiency, Regulate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C309/14C07C303/02
Inventor 车晓明史为龙张峰闵涛晁阳叶海
Owner NANJING YOKO PHARMA GRP CO LTD