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Application of tree peony bark extract to preparation of medicament for treating depression

A kind of Cortex Moutan extract and technology of Cortex Moutan, applied in the field of medicine, can solve the problems of side effects, blurred vision, public report on the application of Cortex Moutan

Inactive Publication Date: 2012-09-19
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drugs currently used to treat depression mainly include tricyclic antidepressants, monoamine oxidase inhibitors, and serotonin reuptake inhibitors, but all have varying degrees of side effects, such as drowsiness, blurred vision, high blood pressure, convulsions, and libido low, etc., which limits its widespread use
However, there is no public report about the application of Moutan cortex extract in the preparation of drugs for the treatment of depression

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Given in the technical scheme of above-mentioned content of the invention, described extract is:

[0010] A. Water extract of Moutan Cortex powder: crush the decoction pieces of Moutan Cortex, sieve through 40-60 mesh to form coarse powder, add 10 mL of water (W / V=1︰10) for every 1 g of Moutan Cortex coarse powder, and reflux extraction 3 times, 2 hours each time, filter, combine the filtrates, and recover the water, so that the concentration of the medicinal solution is calculated by crude drug, which is equivalent to 1 g / mL containing Moutan Cortex.

[0011] B. Ethanol extract with a mass concentration of Moutan Cortex of 20%: crush the decoction pieces of Moutan Cortex, sieve through a 40-60 mesh into a coarse powder, add 10 mL of ethanol with a mass concentration of 20% per 1 g of Moutan Cortex coarse powder (W / V=1︰10), reflux extraction 3 times, 2 h each time, filter, combine the filtrates, recover ethanol until there is no alcohol smell, and make the concentratio...

Embodiment 2

[0020] Given in the technical scheme of above-mentioned content of the invention, described pill, powder, dripping pill, tablet or a kind of capsule, are to get respectively 250g of Cortex Moutan coarse powder, every 250g add 2500mL (W / V=1: 10) Water, 20%-75% ethanol, ethyl acetate, petroleum ether or any solvent in 120# gasoline, reflux extraction 3 times, each time 2 hours, filter the combined filtrate, recover the solvent to the extract, dry, Pulverize, pass through a 100-mesh sieve, add 12.5g of magnesium stearate or starch, dextrin, mix well, and make pills, powders, dripping pills, tablets or capsules.

[0021] The applicant should point out that the above-mentioned embodiments should be understood as only for illustrating the present invention but not for limiting the protection scope of the present invention. After reading the contents of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equiva...

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PUM

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Abstract

The invention relates to an application of a tree peony bark extract to preparation of a medicament for treating depression, which can be used for effectively solving the problems of prevention and treatment of depression. According to the technical scheme for solving the problem, the tree peony bark extract is obtained by the following steps of: smashing a Chinese medicine, i.e., tree peony bark; and performing reflux extraction by using any solvent selected from water, 20-95 percent ethanol, acetone, ethyl acetate, petroleum or petroleum ether according to the conventional method. The extract prepared from the Chinese medicine, i.e., tree peony bark is used for preparing a medicament for treating depression. According to the application, the problems of prevention and treatment of depression are solved, and a novel application of the tree peony bark to prevention and treatment of depression is developed; and the application belongs to an innovation on Chinese medicine.

Description

technical field [0001] The invention relates to the field of medicine, and is a new application of the antidepressant effect of the traditional Chinese medicine Moutan Cortex, in particular the application of the Moutan Cortex extract in the preparation of medicines for treating depression. Background technique [0002] Depression is a group of disorders characterized by marked and persistent low mood, rigid behavior, and pessimistic world-weariness. It's so common, in fact, that it's been called the "common cold" of mental illness, and it's also a serious, life-threatening illness that afflicts tens of millions of people around the world. The drugs currently used to treat depression mainly include tricyclic antidepressants, monoamine oxidase inhibitors, and serotonin reuptake inhibitors, but all have varying degrees of side effects, such as drowsiness, blurred vision, high blood pressure, convulsions, and libido Low, etc., thereby limiting its widespread use. [0003] Cor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P25/24A61K125/00
Inventor 王君明张月月
Owner HENAN UNIV OF CHINESE MEDICINE
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