Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Chinese medicinal compound with tongue squamous cell carcinoma resisting effect and preparation method thereof

The technology of tongue squamous cell carcinoma and traditional Chinese medicine is applied in the application field of preparing a medicine for treating tongue phosphorus cancer, which can solve the problems of toxic and side effects, poor prognosis, influence on patients' life, health and quality of life, etc., and achieves the effect of convenient clinical use.

Inactive Publication Date: 2012-09-19
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the incidence of tongue cancer has been increasing year by year. Although the diagnosis and treatment of tongue cancer have been greatly improved, the prognosis is poor due to frequent tongue activities and rich lymphatic and blood supply in the tongue tissue. The survival rate is still low
At present, the treatment schemes routinely adopted by domestic and foreign medical circles in the treatment of oral mucosal malignant tumors are chemical drug treatment, radiotherapy and surgical resection. Research, but also the iatrogenic problems and corresponding diseases caused by the toxic and side effects of chemical drugs, the radiation damage caused by radiotherapy, and the total or partial resection of sexual organs in surgical plans, have brought great pain to patients and seriously affected patients. health and quality of life

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chinese medicinal compound with tongue squamous cell carcinoma resisting effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1. A Chinese medicine compound with anti-tongue squamous cell carcinoma effect, which is made from the following raw materials in parts by weight:

[0021] 10 parts of winter melon seeds, 12 parts of French Pinellia, 10 parts of Dannanxing, 12 parts of shanzake mushrooms, 10 parts of cat's claw, 10 parts of golden buckwheat, 10 parts of Houttuynia cordata, 15 parts of agrimony, 12 parts of sumac, red 15 parts of flowers, 10 parts of Radix Ginseng, 10 parts of Polygonatum Polygonatum, and 10 parts of Ophiopogon japonicus.

[0022] 2. The preparation method of the Chinese medicine compound with anti-tongue squamous cell carcinoma effect is:

[0023] Take 10 parts of winter melon seeds, 12 parts of Pinellia chinensis, 10 parts of Dannanxing, 12 parts of shanzi mushroom, 10 parts of cat's claw, 10 parts of golden buckwheat, 10 parts of Houttuynia cordata, 15 parts of agrimony, 12 parts of sumac, Add 15 parts of safflower, 10 parts of Radix Ginseng, 10 parts of Polygonatum ...

Embodiment 2

[0025] 1. A Chinese medicine compound with anti-tongue squamous cell carcinoma effect, which is made from the following raw materials in parts by weight:

[0026] 20 parts of winter melon seeds, 24 parts of French Pinellia, 20 parts of Dannanxing, 24 parts of shanzi mushroom, 20 parts of cat's claw, 20 parts of golden buckwheat, 20 parts of Houttuynia cordata, 30 parts of agrimony, 24 parts of sumac, red 30 parts of flowers, 20 parts of Radix Ginseng, 20 parts of Polygonatum Polygonatum, and 20 parts of Ophiopogon japonicus.

[0027] 2. The preparation method of the Chinese medicine compound with anti-tongue squamous cell carcinoma effect is:

[0028] Take 20 parts of winter melon seeds, 24 parts of Pinellia chinensis, 20 parts of Dannanxing, 24 parts of sage mushrooms, 20 parts of cat's claw, 20 parts of golden buckwheat, 20 parts of Houttuynia cordata, 30 parts of agrimony, 24 parts of sumac, Add 30 parts of safflower, 20 parts of Radix Ginseng, 20 parts of Polygonatum Poly...

Embodiment 3

[0029] Example 3 Experimental research on anti-lingual phosphorus cancer

[0030] 1. Materials

[0031] 1.1 Cell lines: SAS cells were donated by Professor Zheng Jinhua of Harbin Medical University. The tongue squamous cell line TCA-8113 was purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences. It was passaged and preserved in our laboratory.

[0032] 1.2 Drugs: the Chinese medicine compound extract provided in Embodiment 1 of the present invention.

[0033] 1.3 The main reagents are penicillin (Shandong Lukang), streptomycin sulfate (Amresco), MTT (thiazole salt, Genebase), trypsin (Nanjing Shengxing), EDTA (Sigma), RPMI-1640 medium (GIBCO), iodide Propidium (PI, Sigma, USA), RPMI-1640 (GIBCO), newborn calf serum (Lanzhou Minhai, Hyclone joint venture), 6-well culture plate and 24-well plate (Corning product). PEG2 detection ELISA kit (R & D company).

[0034] 1.4 Instruments Ultra-clean bench (Sujing Company, SW-CJ-1F), CO 2Incubator (Thermo, USA), in...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a Chinese medicinal compound with a tongue squamous cell carcinoma resisting effect and a preparation method thereof. The Chinese medicinal compound is prepared from the following raw materials in parts by weight: 10-20 parts of waxgourd seed, 12-24 parts of rhizoma pinellinae praeparata, 10-20 parts of arisaema cum bile, 12-24 parts of indian iphigenia bulb, 10-20 parts of ternate buttercup root, 10-20 parts of wild buckwheat rhizome, 10-20 parts of heartleaf houttuynia herb, 15-30 parts of hairyvein agrimonia herb and bud, 12-24 parts of sappan wood, 15-30 parts of safflower, 10-20 parts of straight ladybell root, 10-20 parts of fragrant solomonseal rhizome and 10-20 parts of dwarf lilyturf root. The Chinese medicinal compound with the tongue squamous cell carcinoma resisting effect provided by the invention is prepared by selecting raw materials according to the traditional Chinese medicine theory and the pathogenesis of tongue squamous cell carcinoma, and components are blended scientifically and reasonably; and as proved by a pharmacodynamics experiment result, the Chinese medicinal compound can contribute to remarkably lowering the content of PGE2, has a very good tongue squamous cell carcinoma resisting effect, is free from untoward effects after long-term use, and can be developed into a new generation of tongue squamous cell carcinoma resisting medicament.

Description

[0001] technical field [0002] The invention relates to a compound traditional Chinese medicine, in particular to a compound traditional Chinese medicine with an anti-tongue squamous cell carcinoma effect and its application in the preparation of medicines for treating tongue squamous cell carcinoma. Background technique [0003] Tongue cancer is one of the most common malignant tumors in oral cancer. Oral cancer is a general term for malignant tumors that occur in the oral cavity. It is one of the more common malignant tumors in the head and neck, ranking sixth in the world. Most of them belong to squamous cell carcinoma. Mutations. In recent years, the incidence of tongue cancer has been increasing year by year. Although the diagnosis and treatment of tongue cancer have been greatly improved, the prognosis is poor due to frequent tongue activities and rich lymphatic and blood supply in the tongue tissue. Its survival rate is still low. At present, the treatment schemes...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P35/00A61P1/02
Inventor 张军峰詹瑧张旭冯颖孟玉芬
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products