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Sodium hyaluronate eye drops and a preparation method thereof
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A technology of sodium hyaluronate and eye drops, which is applied in the field of medicine, can solve the problems of easy contamination and growth of bacteria, and achieve the effects of stable and feasible preparation process, prolonging tear film breakup time and good stability
Active Publication Date: 2013-08-07
ZHEJIANG JIANFENG PHARM CO LTD
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[0018] In order to solve the technical defects of the stability of sodium hyaluronate and the tendency to be contaminated and grow bacteria, an object of the present invention is to provide a sodium hyaluronate eye drop, which has good antibacterial performance and good stability specialty
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Embodiment 1
[0068] Sodium hyaluronate eye drops, each 100ml consists of the following components:
[0073] Borneol 10mg, add water for injection to 100ml.
[0074] The preparation method of above-mentioned sodium hyaluronate eye drops, comprises the following steps:
[0075] 1) Take 50% of the prepared water for injection in advance and cool it to 50~60°C and pour it into the mixing bucket, accurately weigh the sodium hyaluronate, add the sodium hyaluronate while stirring, soak until completely dissolved;
[0076] 2) Take 30% of the prepared water for injection and put it in a stainless steel bucket, accurately weigh boric acid, borax, disodium edetate, 6-aminocaproic acid, mannitol, and sodium chloride, and add them into the stainless steel bucket in sequence , after stirring an...
Embodiment 2
[0084] Sodium hyaluronate eye drops, each 100ml consists of the following components:
[0097] Borneol 12mg, add water for injection to 100ml.
[0098] The preparation method is shown in Example 1.
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Abstract
The invention relates to the field of medicine, in particular to sodium hyaluronate eye drops and a preparation method thereof. Sodium hyaluronate eye drops, the eye drops are composed of the following components per 100ml: sodium hyaluronate 80~150mg, boric acid 130~200mg, borax 10~20mg, edetate disodium 8~15mg, 6-aminohexyl Acid 80~160mg, mannitol 80~160mg, sodiumchloride 600~800mg, benzalkonium chloride 3~10mg, borneol 8~15mg, add water for injection to 100ml, and adjust the pH to 6.0~7.8. The eye drop of the invention has the effect of promoting healing on corneal epithelial damage, can obviously prolong tear film breakup time, and has better effect on improving dry eye disease symptoms. At the same time, the present invention has good stability at room temperature, and the data of each batch are similar, indicating that the preparation process is stable and feasible. Used within the validity period, all indicators of HA-Na are within the quality control range.
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